2005 Vol. 23, No. 2
Display Method:
2005, (2): 65-71.
Abstract:
With the problem of fungal infections getting more serious, it is important to development the novel, safe and effective antifungal drugs. According to different targets including cell wall, cell membrane, protein, nucleic acid and electron transportion, the development of research in these five targets were reviewed in this paper.
With the problem of fungal infections getting more serious, it is important to development the novel, safe and effective antifungal drugs. According to different targets including cell wall, cell membrane, protein, nucleic acid and electron transportion, the development of research in these five targets were reviewed in this paper.
2005, (2): 80-83.
Abstract:
Objective To observe and analyze the influence that new drugs putting in the hospital formulary on hospital drugs consumption. Methods Data of drugs consumption were collected from a teaching hospital with 1000 beds, the new drugs and the old drugs variety and quota were caculated separately. By using SPSS software package to analyze diversification of new drugs variety and quota, and influence of drugs expense total amount. Result The index model was Q=53.29x0.0716, and the multiple regression equation was Q=2217.533-7.092a+4.271b. Conclusion The size of new drugs expenditure plays an important role in total drugs consumption. But the new drugs variety is not relevant to the drugs expense.
Objective To observe and analyze the influence that new drugs putting in the hospital formulary on hospital drugs consumption. Methods Data of drugs consumption were collected from a teaching hospital with 1000 beds, the new drugs and the old drugs variety and quota were caculated separately. By using SPSS software package to analyze diversification of new drugs variety and quota, and influence of drugs expense total amount. Result The index model was Q=53.29x0.0716, and the multiple regression equation was Q=2217.533-7.092a+4.271b. Conclusion The size of new drugs expenditure plays an important role in total drugs consumption. But the new drugs variety is not relevant to the drugs expense.
2005, (2): 84-85,108.
Abstract:
Objective To select the optimal extracting technology of active components in oyster soft tissue. Methods The extracting technonogy was investigated using the orthogonal designed methods L9(34), with the content of taurine and the amount of the extracts as the detecting index. Results The optimal extracting technology was as follows:the oyster soft tissue was refluxed in 10 times of the amount of water for two times, 1h each time. Conclusion This extracting technology is workable and reliable.
Objective To select the optimal extracting technology of active components in oyster soft tissue. Methods The extracting technonogy was investigated using the orthogonal designed methods L9(34), with the content of taurine and the amount of the extracts as the detecting index. Results The optimal extracting technology was as follows:the oyster soft tissue was refluxed in 10 times of the amount of water for two times, 1h each time. Conclusion This extracting technology is workable and reliable.
2005, (2): 86-88.
Abstract:
Objective To choose the best preparing technology of vitaminE cream, improve its quality ;Methods The vitamin E's recall rate and preparation stability was the evaluating index. Orthogonal design method was used. Results The factors influenting extraction efficiency as follows were: A >D>C>B(A: the temperature when added vinaminE, B: the amount of emulsifier' percent, C: the way of mixing, D: the time of emulsifying), We got a result that the optimized technology was A3B2C3D2 by experimentation,namely the amount of emulsifier' percent was 2.5%, the temperature was 55℃,the way of mixing was high-speed cutting, emulsifying for 30min at 55℃. Conclusion The optimal technology is stable and high efficient.
Objective To choose the best preparing technology of vitaminE cream, improve its quality ;Methods The vitamin E's recall rate and preparation stability was the evaluating index. Orthogonal design method was used. Results The factors influenting extraction efficiency as follows were: A >D>C>B(A: the temperature when added vinaminE, B: the amount of emulsifier' percent, C: the way of mixing, D: the time of emulsifying), We got a result that the optimized technology was A3B2C3D2 by experimentation,namely the amount of emulsifier' percent was 2.5%, the temperature was 55℃,the way of mixing was high-speed cutting, emulsifying for 30min at 55℃. Conclusion The optimal technology is stable and high efficient.
2005, (2): 88-90.
Abstract:
Objective To prepare diethylstilbestrol ointment and establish its method of quality control. Methods The diethylstil-bestrol ointment was prepared according to prescription. The HPLC was used to detect the content at 240nm with carbamazepine as the internal standard,and C18 was used as chromatography column while methanol-water(6:4) as mobile phase. Results The ratio of chromatographic peak area of diethylstilbestrol and internal standard correlated linearly with the concentration ranging from 8.0 -32.0μg/mL(r=9999). The average recovery was 98.9% and RSD was 0.33%. Conclusion The preparation technique was practical and the determination of content was credible, and can be utilized in hospital preparation and quality control.
Objective To prepare diethylstilbestrol ointment and establish its method of quality control. Methods The diethylstil-bestrol ointment was prepared according to prescription. The HPLC was used to detect the content at 240nm with carbamazepine as the internal standard,and C18 was used as chromatography column while methanol-water(6:4) as mobile phase. Results The ratio of chromatographic peak area of diethylstilbestrol and internal standard correlated linearly with the concentration ranging from 8.0 -32.0μg/mL(r=9999). The average recovery was 98.9% and RSD was 0.33%. Conclusion The preparation technique was practical and the determination of content was credible, and can be utilized in hospital preparation and quality control.
2005, (2): 99-102.
Abstract:
Objective To establish the method for determination of mangiferin and neo-mangiferin in Rhizoma Anemarrhenae. Method The content was determined by HPLC. A Zorbax Eclipse XDB-C18 column(4.6mm×250mm,5μm) with a grient mobile phase composed of 25 mmol/L dihydrophosphate potassium and acetonitrile were used. The detection wavelength was 257 nm and the flow rate was 1.0mL/min. Results The calibration curves of mangiferin were linear between 14.2-568.5μg/mL(r=0.9999), the neo-mangiferin were 14.8-590.5μg/mL. The withinday precision RSD was both less than 4.5% and the interday precision RSD was less than 3.9%. Conclusion The method is simple, rapid, accurate and is suitable for the determination of mangiferin and neo-mangiferin.
Objective To establish the method for determination of mangiferin and neo-mangiferin in Rhizoma Anemarrhenae. Method The content was determined by HPLC. A Zorbax Eclipse XDB-C18 column(4.6mm×250mm,5μm) with a grient mobile phase composed of 25 mmol/L dihydrophosphate potassium and acetonitrile were used. The detection wavelength was 257 nm and the flow rate was 1.0mL/min. Results The calibration curves of mangiferin were linear between 14.2-568.5μg/mL(r=0.9999), the neo-mangiferin were 14.8-590.5μg/mL. The withinday precision RSD was both less than 4.5% and the interday precision RSD was less than 3.9%. Conclusion The method is simple, rapid, accurate and is suitable for the determination of mangiferin and neo-mangiferin.
2005, (2): 103-104.
Abstract:
Objective To evaluate the economic effectiveness of domestic ulinastatin and sandostain in the treatment of acute pancreatitis. Methods 41 cases with acute pancreatitis were divided into 2 groups according to the therapeutic drug: the ulinastatin group and the sandostain group. The two groups were compared by cost-minimization analysis of pharmacoeconomics. Results There is no significant difference in clinical therapeutic effect between two groups, but the cost of the sandostain group is much higher than the ulinastatin group. Conclusion The cost of domestic ulinastatin is minimization.
Objective To evaluate the economic effectiveness of domestic ulinastatin and sandostain in the treatment of acute pancreatitis. Methods 41 cases with acute pancreatitis were divided into 2 groups according to the therapeutic drug: the ulinastatin group and the sandostain group. The two groups were compared by cost-minimization analysis of pharmacoeconomics. Results There is no significant difference in clinical therapeutic effect between two groups, but the cost of the sandostain group is much higher than the ulinastatin group. Conclusion The cost of domestic ulinastatin is minimization.
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