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Volume 23 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2005  >  (2): 88-90

XIONG Feng-ying, WU Min, WU Hong-wen, CHEN Guo-ping, GUO Xin-fu. Preparation and quality control of diethylstilbestrol ointment[J]. Journal of Pharmaceutical Practice and Service, 2005, (2): 88-90.
Citation: XIONG Feng-ying, WU Min, WU Hong-wen, CHEN Guo-ping, GUO Xin-fu. Preparation and quality control of diethylstilbestrol ointment[J]. Journal of Pharmaceutical Practice and Service, 2005, (2): 88-90.
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Preparation and quality control of diethylstilbestrol ointment

  • Received Date: 2004-09-21
  • Objective To prepare diethylstilbestrol ointment and establish its method of quality control. Methods The diethylstil-bestrol ointment was prepared according to prescription. The HPLC was used to detect the content at 240nm with carbamazepine as the internal standard,and C18 was used as chromatography column while methanol-water(6:4) as mobile phase. Results The ratio of chromatographic peak area of diethylstilbestrol and internal standard correlated linearly with the concentration ranging from 8.0 -32.0μg/mL(r=9999). The average recovery was 98.9% and RSD was 0.33%. Conclusion The preparation technique was practical and the determination of content was credible, and can be utilized in hospital preparation and quality control.
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通讯作者: 陈斌, [email protected]
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Preparation and quality control of diethylstilbestrol ointment

  • Received Date: 2004-09-21

Abstract: Objective To prepare diethylstilbestrol ointment and establish its method of quality control. Methods The diethylstil-bestrol ointment was prepared according to prescription. The HPLC was used to detect the content at 240nm with carbamazepine as the internal standard,and C18 was used as chromatography column while methanol-water(6:4) as mobile phase. Results The ratio of chromatographic peak area of diethylstilbestrol and internal standard correlated linearly with the concentration ranging from 8.0 -32.0μg/mL(r=9999). The average recovery was 98.9% and RSD was 0.33%. Conclusion The preparation technique was practical and the determination of content was credible, and can be utilized in hospital preparation and quality control.

XIONG Feng-ying, WU Min, WU Hong-wen, CHEN Guo-ping, GUO Xin-fu. Preparation and quality control of diethylstilbestrol ointment[J]. Journal of Pharmaceutical Practice and Service, 2005, (2): 88-90.
Citation: XIONG Feng-ying, WU Min, WU Hong-wen, CHEN Guo-ping, GUO Xin-fu. Preparation and quality control of diethylstilbestrol ointment[J]. Journal of Pharmaceutical Practice and Service, 2005, (2): 88-90.
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