2006 Vol. 24, No. 1
Display Method:
2006, (1): 17-20.
Abstract:
Objective :To compare the dissolution of metformin hydrochloride tablets in vitro from fifteen different pharmaceutical factories and provide suggestions for clinical application. Methods :The dissolution tests were carried out with rotating basket.UV method was used to determine the concentration of metformin hydrochloride.The accumulative dissolution based on the labeled amount was calculated and the Weibull's equation was used to model the dissolution parameters.The difference between different groups was statistically evaluated by variance analysis. Results :The dissolution of metformin hydrochloride tablets in vitro from fifteen different pharmaceutical factories conformed to the requirements of Chinese Pharmacopoeia (2005).But significant difference was found among the metformin hydrochloride tablets from fifteen different pharmaceutical factories in dissolution parameter m,T30,T50,Td and T80 (P< 0.01). Conclusion :There was significant difference in dissolution parameters among the metformin hydrochloride tablets from fifteen different pharmaceutical factories.It was indicated that attention should be paid to their clinical application.
Objective :To compare the dissolution of metformin hydrochloride tablets in vitro from fifteen different pharmaceutical factories and provide suggestions for clinical application. Methods :The dissolution tests were carried out with rotating basket.UV method was used to determine the concentration of metformin hydrochloride.The accumulative dissolution based on the labeled amount was calculated and the Weibull's equation was used to model the dissolution parameters.The difference between different groups was statistically evaluated by variance analysis. Results :The dissolution of metformin hydrochloride tablets in vitro from fifteen different pharmaceutical factories conformed to the requirements of Chinese Pharmacopoeia (2005).But significant difference was found among the metformin hydrochloride tablets from fifteen different pharmaceutical factories in dissolution parameter m,T30,T50,Td and T80 (P< 0.01). Conclusion :There was significant difference in dissolution parameters among the metformin hydrochloride tablets from fifteen different pharmaceutical factories.It was indicated that attention should be paid to their clinical application.
2006, (1): 20-22.
Abstract:
Objective :To study the effect of silybin on fibrogenic cytokines production by mouse peritoneal macrophages. Methods :Mouse peritoneal macrophages were primed with calcimycin 10-6 mol/L for 8 h then elicited by lipopolysa(?)harides (LPS) 100 mg/L for 6 h to induce fibrogenic cytokines.Collagen stimulating activities and transforming growth factor β (TGFβ) activities in the macrophage culture supernatants were assessed by [3H]-proline incorporation assay using rat hepatic stellate HSC-T6 cell and [3H]-thymidine incorporation assay using Mv-1-Lu mink lung epithelial cell respectively. Results :Silybin(6.25-50(μg/mL) inhibited LPS-induced collagen stimulating activities and TGFμ production in a concentration dependent manner. Conclusion :Hepatoprotective and an(?)ifibrotic properties of silibin may partly arise from its actions on fibrogenic cytokines production.
Objective :To study the effect of silybin on fibrogenic cytokines production by mouse peritoneal macrophages. Methods :Mouse peritoneal macrophages were primed with calcimycin 10-6 mol/L for 8 h then elicited by lipopolysa(?)harides (LPS) 100 mg/L for 6 h to induce fibrogenic cytokines.Collagen stimulating activities and transforming growth factor β (TGFβ) activities in the macrophage culture supernatants were assessed by [3H]-proline incorporation assay using rat hepatic stellate HSC-T6 cell and [3H]-thymidine incorporation assay using Mv-1-Lu mink lung epithelial cell respectively. Results :Silybin(6.25-50(μg/mL) inhibited LPS-induced collagen stimulating activities and TGFμ production in a concentration dependent manner. Conclusion :Hepatoprotective and an(?)ifibrotic properties of silibin may partly arise from its actions on fibrogenic cytokines production.
2006, (1): 22-25.
Abstract:
Objective :To establish a method for the determination of the entrapment efficiency of silybin liposomes. Methods :First derivative spectrometry was established.The two middle wavelengths were 275nm and 317nm.The detection wavelengths were 274,276, 316 and 318nm,respectively. Results :The calibration curve of silybin was linear in the range of 0-30.3uuuuuuuuuuuug/mL and the correlation coefficient was 0.9995.The average recovery and relative standard deviation were 100.8% and 0.8%,respectively. Conclusion :The method is practicable.
Objective :To establish a method for the determination of the entrapment efficiency of silybin liposomes. Methods :First derivative spectrometry was established.The two middle wavelengths were 275nm and 317nm.The detection wavelengths were 274,276, 316 and 318nm,respectively. Results :The calibration curve of silybin was linear in the range of 0-30.3uuuuuuuuuuuug/mL and the correlation coefficient was 0.9995.The average recovery and relative standard deviation were 100.8% and 0.8%,respectively. Conclusion :The method is practicable.
2006, (1): 25-27.
Abstract:
Objective :To establish a HPLC-ELSD method for determining the content of busulfan in busulfan tablets. Methods : The chromatographic conditions were as follows:SHIMADZU C8 column(250mm×4.6mm,5μm),the mobile phase:water-acetonitrile (75-25),the flow rate:1.0mL/min,and the detector:ELSD,the carrier gas:nitrogen,the flow rate:2.0 bar. Results :The standard curve of busulfan was linear over the rage of 0. 25-0.75mg/mL(r=0.9999).The average recovery was 99.7%. Conclusion :This method is accurate and specificity,and it can be used on the quality control of busulfan tablets.
Objective :To establish a HPLC-ELSD method for determining the content of busulfan in busulfan tablets. Methods : The chromatographic conditions were as follows:SHIMADZU C8 column(250mm×4.6mm,5μm),the mobile phase:water-acetonitrile (75-25),the flow rate:1.0mL/min,and the detector:ELSD,the carrier gas:nitrogen,the flow rate:2.0 bar. Results :The standard curve of busulfan was linear over the rage of 0. 25-0.75mg/mL(r=0.9999).The average recovery was 99.7%. Conclusion :This method is accurate and specificity,and it can be used on the quality control of busulfan tablets.
2006, (1): 27-29,34.
Abstract:
Objective :To establish a method for determining residual solvents such as methanol,ethanol and acetone in propy-phenazone by headspace gas chromatography. Methods :The GC was equipped with a headspace injector and a flame-ionization dete(?) tor.A 0. 53mm×30m, DB-624 chromatographic column(coated with 6% cyanopropylphenyl-94% dimethyl polysiloxane) was adopted. The carrier gas was nitrogen.The assay of residual solvents were calculated according to the external standard method. Results :Only ethanol was found in the sample of propyphenazone.The standard curves were linear over the ranges of 0.10-164.96μg/mL(r= 0.9999) for ethanol,0.10-163. 36μg/mL(r=1.000 0) for acetone and 0.21-164.72μg/mL(r=0.999 9) for methanol. The limits of quantitation were 0. 3μg/mL for methanol and ethanol, 0. 1μg/mL for acetone.The average recoveries were 101. 0% ( RSD = 4.8% ,n=6)for methanol,99.89%(RSD=4.4%,n=6) for ethanol,99.85%(RSD=3.4%,n=6) for acetone. Conclusion :This method appeared to be sensitive,accurate,repeatable and easy to operate and was suitable for determining residual solvents of propyphenazone.
Objective :To establish a method for determining residual solvents such as methanol,ethanol and acetone in propy-phenazone by headspace gas chromatography. Methods :The GC was equipped with a headspace injector and a flame-ionization dete(?) tor.A 0. 53mm×30m, DB-624 chromatographic column(coated with 6% cyanopropylphenyl-94% dimethyl polysiloxane) was adopted. The carrier gas was nitrogen.The assay of residual solvents were calculated according to the external standard method. Results :Only ethanol was found in the sample of propyphenazone.The standard curves were linear over the ranges of 0.10-164.96μg/mL(r= 0.9999) for ethanol,0.10-163. 36μg/mL(r=1.000 0) for acetone and 0.21-164.72μg/mL(r=0.999 9) for methanol. The limits of quantitation were 0. 3μg/mL for methanol and ethanol, 0. 1μg/mL for acetone.The average recoveries were 101. 0% ( RSD = 4.8% ,n=6)for methanol,99.89%(RSD=4.4%,n=6) for ethanol,99.85%(RSD=3.4%,n=6) for acetone. Conclusion :This method appeared to be sensitive,accurate,repeatable and easy to operate and was suitable for determining residual solvents of propyphenazone.
2006, (1): 35-38.
Abstract:
Objective :To discuss the main problems of Chinese hospital pharmacy administration in the early 21th century Method :The development history of hospital pharma(?)y and the events in the academy of hospital pharmacy were analyzed. Results :The transformation of hospital pharmacy working mode and the development of hospital pharmacy are two critical challenges for Chinese hospital pharmacy administration in 21th century. Conclusion :The key countermeasures are strengthening the leading of policy,accomplishing the regulation system,expanding the association functions,and finally arousing the working spirits of pharmacists.
Objective :To discuss the main problems of Chinese hospital pharmacy administration in the early 21th century Method :The development history of hospital pharma(?)y and the events in the academy of hospital pharmacy were analyzed. Results :The transformation of hospital pharmacy working mode and the development of hospital pharmacy are two critical challenges for Chinese hospital pharmacy administration in 21th century. Conclusion :The key countermeasures are strengthening the leading of policy,accomplishing the regulation system,expanding the association functions,and finally arousing the working spirits of pharmacists.
2006, (1): 39-41.
Abstract:
Objective :To analyse the function of the ABC rule of periodical and quantitative management in managing drug stock control. Methods :Setted the lower and the upper limitation of the storage of every kind of drug with the ABC rule of periodical and quantitative management. Results :The drug stock was controlled within the amount of sale in 7 days effectively.The velocity of fund was also speed up,and the frequency of purchase was reduced in the same time. Conclusion :The ABC rule of periodical and quantitative management can set limitation more reasonable and convenient,and easier to put in practice than other ways.
Objective :To analyse the function of the ABC rule of periodical and quantitative management in managing drug stock control. Methods :Setted the lower and the upper limitation of the storage of every kind of drug with the ABC rule of periodical and quantitative management. Results :The drug stock was controlled within the amount of sale in 7 days effectively.The velocity of fund was also speed up,and the frequency of purchase was reduced in the same time. Conclusion :The ABC rule of periodical and quantitative management can set limitation more reasonable and convenient,and easier to put in practice than other ways.
2006, (1): 46-50.
Abstract:
Objective :To analyze the situation and trend of the drug utilization of renal transplant inpatients in our hospital,and promote rational drug use. Methods :the records and relevant data of renal transplant inpatients during 2002-2004 were collected, and analyzed according to drug cost and defined daily dose (DDDs)ranking. Results :Total drug cost per case,daily drug cost per patient and total drug cost were increasing during 2002-2004.The top 20 drugs of cost ranking were mainly immunosuppressant,anti bacterials,anti-ulcer and anti-embolism drugs,and the DUIs were not more than 1. Conclusion :It shows that the drug utilization of renal transplant inpatients is basically rational,however something unreasonable should not be ignored,for instance,too expensive and much more antibacterials used.
Objective :To analyze the situation and trend of the drug utilization of renal transplant inpatients in our hospital,and promote rational drug use. Methods :the records and relevant data of renal transplant inpatients during 2002-2004 were collected, and analyzed according to drug cost and defined daily dose (DDDs)ranking. Results :Total drug cost per case,daily drug cost per patient and total drug cost were increasing during 2002-2004.The top 20 drugs of cost ranking were mainly immunosuppressant,anti bacterials,anti-ulcer and anti-embolism drugs,and the DUIs were not more than 1. Conclusion :It shows that the drug utilization of renal transplant inpatients is basically rational,however something unreasonable should not be ignored,for instance,too expensive and much more antibacterials used.
2006, (1): 50-53.
Abstract:
Objective :To investigate the clinical characteristics and trend of drugs utilization of cardiovascular diseases in our hospital during 2001-2004. Methods :The data of consumption of cardiovascular drugs were collected then analysed and studied according to their order of kinds,DDDs and sum of money. Results :The sum of money and DDDs of the cardiovascular drugs were increasing in the past four years.The most often used were anti-anginal,vasodilating agents and antihypertensives. Conclusion :Complicated in classification,numerous in kinds and extensive in clinical application,the cardiovascular drugs have enormous market requirements and a capacious exploitation foreground.
Objective :To investigate the clinical characteristics and trend of drugs utilization of cardiovascular diseases in our hospital during 2001-2004. Methods :The data of consumption of cardiovascular drugs were collected then analysed and studied according to their order of kinds,DDDs and sum of money. Results :The sum of money and DDDs of the cardiovascular drugs were increasing in the past four years.The most often used were anti-anginal,vasodilating agents and antihypertensives. Conclusion :Complicated in classification,numerous in kinds and extensive in clinical application,the cardiovascular drugs have enormous market requirements and a capacious exploitation foreground.
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