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Volume 24 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (1): 20-22

ZHUANG Dong-ping, Wang Shuo-feng, ZHANG Yue-fan, GUI Min, ZHANG Min, ZHANG Jun-ping. Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 20-22.
Citation: ZHUANG Dong-ping, Wang Shuo-feng, ZHANG Yue-fan, GUI Min, ZHANG Min, ZHANG Jun-ping. Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 20-22.
shu

Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages

  • 1.

    Department of Pharmacy, Huian People Hospital, Huian 362100, China

  • 2.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2005-09-05
  • Objective :To study the effect of silybin on fibrogenic cytokines production by mouse peritoneal macrophages. Methods :Mouse peritoneal macrophages were primed with calcimycin 10-6 mol/L for 8 h then elicited by lipopolysa(?)harides (LPS) 100 mg/L for 6 h to induce fibrogenic cytokines.Collagen stimulating activities and transforming growth factor β (TGFβ) activities in the macrophage culture supernatants were assessed by [3H]-proline incorporation assay using rat hepatic stellate HSC-T6 cell and [3H]-thymidine incorporation assay using Mv-1-Lu mink lung epithelial cell respectively. Results :Silybin(6.25-50(μg/mL) inhibited LPS-induced collagen stimulating activities and TGFμ production in a concentration dependent manner. Conclusion :Hepatoprotective and an(?)ifibrotic properties of silibin may partly arise from its actions on fibrogenic cytokines production.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages

  • 1. Department of Pharmacy, Huian People Hospital, Huian 362100, China
  • 2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2005-09-05

Abstract: Objective :To study the effect of silybin on fibrogenic cytokines production by mouse peritoneal macrophages. Methods :Mouse peritoneal macrophages were primed with calcimycin 10-6 mol/L for 8 h then elicited by lipopolysa(?)harides (LPS) 100 mg/L for 6 h to induce fibrogenic cytokines.Collagen stimulating activities and transforming growth factor β (TGFβ) activities in the macrophage culture supernatants were assessed by [3H]-proline incorporation assay using rat hepatic stellate HSC-T6 cell and [3H]-thymidine incorporation assay using Mv-1-Lu mink lung epithelial cell respectively. Results :Silybin(6.25-50(μg/mL) inhibited LPS-induced collagen stimulating activities and TGFμ production in a concentration dependent manner. Conclusion :Hepatoprotective and an(?)ifibrotic properties of silibin may partly arise from its actions on fibrogenic cytokines production.

ZHUANG Dong-ping, Wang Shuo-feng, ZHANG Yue-fan, GUI Min, ZHANG Min, ZHANG Jun-ping. Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 20-22.
Citation: ZHUANG Dong-ping, Wang Shuo-feng, ZHANG Yue-fan, GUI Min, ZHANG Min, ZHANG Jun-ping. Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 20-22.
shu

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