2023 Vol. 41, No. 3
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2023, 41(3): 135-138, 145.
doi: 10.12206/j.issn.2097-2024.202202058
Abstract:
Nanocarriers prepared from organic or inorganic materials are widely used in drug targeting system and diagnosis and treatment of disease. However, there are some problems, such as poor targeting, short circulation time in vivo and improvement in the...
Nanocarriers prepared from organic or inorganic materials are widely used in drug targeting system and diagnosis and treatment of disease. However, there are some problems, such as poor targeting, short circulation time in vivo and improvement in the...
2023, 41(3): 139-145.
doi: 10.12206/j.issn.2097-2024.202109112
Abstract:
Breast cancer is a kind of malignant tumor discovered lately, with a high incidence and a poor prognosis. The shortage of relevant biological biomarkers lead to the unsatisfactory treatment efficacy and the early diagnosis in breast cancer. Metabolom...
Breast cancer is a kind of malignant tumor discovered lately, with a high incidence and a poor prognosis. The shortage of relevant biological biomarkers lead to the unsatisfactory treatment efficacy and the early diagnosis in breast cancer. Metabolom...
2023, 41(3): 146-148, 186.
doi: 10.12206/j.issn.2097-2024.202208061
Abstract:
As a natural compound with high efficiency and low toxicity, cryptotanshinone (CTS) has a good anti-fibrosis effect in various organs and tissues. However, its mechanism of action has not been clearly defined, and there is no systematic literature re...
As a natural compound with high efficiency and low toxicity, cryptotanshinone (CTS) has a good anti-fibrosis effect in various organs and tissues. However, its mechanism of action has not been clearly defined, and there is no systematic literature re...
2023, 41(3): 149-154, 159.
doi: 10.12206/j.issn.2097-2024.202206018
Abstract:
Objective To construct a cardiovascular chip model for evaluating the damage of vascular glycocalyx induced by four marine toxins: okadaic acid (OA), conotoxin (CTX), tetrodotoxin (TTX) and gymnodimine (GYM), and explore the protective effect of tr...
2023, 41(3): 155-159.
doi: 10.12206/j.issn.2097-2024.202202030
Abstract:
Objective To explore the effect and mechanism of Bajitianwan on preventing D-galactose (D-gal)-induced osteoblast bone loss. Methods Osteoblasts isolated from 24 h old Wistar rats were injured by D-gal and intervened with Bajitianwan extract. ...
2023, 41(3): 160-167, 196.
doi: 10.12206/j.issn.2097-2024.202206066
Abstract:
Objective To explore the anti-tumor mechanism of saffron (Crocus sativus L.) by network pharmacology and reverse molecular docking techniques. Methods The main chemical components of saffron were obtained by searching published literature and...
2023, 41(3): 168-172, 191.
doi: 10.12206/j.issn.2097-2024.202211015
Abstract:
Objective To study the pharmacokinetics of HMS-01 in mice and provide support for subsequent studies. Methods L iquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to establish a sensitive and specific method for the determination of...
2023, 41(3): 173-176.
doi: 10.12206/j.issn.2097-2024.202112055
Abstract:
Objective To make a textual research on Zisu about the name, origin, morphology and efficacy, a dual-purpose medicinal and edible plant, in order to make the original clear and provide reference basis for clinical application. Methods Textual ...
2023, 41(3): 177-181.
doi: 10.12206/j.issn.2097-2024.202104055
Abstract:
Objective To study the eye irritation and the pharmacokinetics of tacrolimus-loaded cationic nanoemulsion-based in-situ gel in rabbits. Methods The eye irritation of tacrolimus-loaded cationic nanoemulsion-based in-situ gel in rabbits was obse...
2023, 41(3): 182-186.
doi: 10.12206/j.issn.2097-2024.202208060
Abstract:
Objective To establish a detection method for the determination of tetrodotoxin (TTX) in sustained-release microspheres. Methods T he HPLC separation of tetrodotoxin was performed on an Agilent ZORBAX SB-C18 column (4.6mm×150mm,5 μm) with acetonit...
2023, 41(3): 187-191.
doi: 10.12206/j.issn.2097-2024.202211075
Abstract:
Combretum indicum can kill insects and benefit the spleen and stomach, which is the most important medicine to treat children's diseases. The classics of materia medica, calendar edition of Chinese Pharmacopoeia, local processing standards and relate...
Combretum indicum can kill insects and benefit the spleen and stomach, which is the most important medicine to treat children's diseases. The classics of materia medica, calendar edition of Chinese Pharmacopoeia, local processing standards and relate...
2023, 41(3): 192-196.
doi: 10.12206/j.issn.2097-2024.202206023
Abstract:
Objective To establish a method for the determination of cisatracurium besylate in human plasma by UPLC-MS/MS which could be used in the monitoring of drug residual in plasma of elderly patients after operation. Methods T he samples were precipita...
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