留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

SGLT2抑制剂治疗糖尿病研究进展

丁海峰 曹永兵 安毛毛 贾鑫明 姜远英

丁海峰, 曹永兵, 安毛毛, 贾鑫明, 姜远英. SGLT2抑制剂治疗糖尿病研究进展[J]. 药学实践与服务, 2011, 29(2): 89-92,116.
引用本文: 丁海峰, 曹永兵, 安毛毛, 贾鑫明, 姜远英. SGLT2抑制剂治疗糖尿病研究进展[J]. 药学实践与服务, 2011, 29(2): 89-92,116.
DING Hai-feng, CAO Yong-bing, AN Mao-mao, JIA Xin-ming, JIANG Yuan-ying. Research on type 2 sodium glucose co-transporters in diabetes treatment[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 89-92,116.
Citation: DING Hai-feng, CAO Yong-bing, AN Mao-mao, JIA Xin-ming, JIANG Yuan-ying. Research on type 2 sodium glucose co-transporters in diabetes treatment[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 89-92,116.

SGLT2抑制剂治疗糖尿病研究进展

Research on type 2 sodium glucose co-transporters in diabetes treatment

  • 摘要: 近年来,钠-葡萄糖协同转运蛋白2(type 2 sodium glucose co-transporters,SGLT2)抑制剂作为一种新型的治疗糖尿病药物成为研究热点。SGLT2在肾近端小管葡萄糖重吸收中起着非常重要的作用;抑制肾脏SGLT2可以促进Ⅱ型糖尿病人尿糖的排泄,使其血糖恢复正常而不会有低血糖的风险。临床实验表明,SGLT2抑制剂对Ⅱ型糖尿病的治疗效果明显,且具有降低体重、无低血糖风险等优点,目前,许多SGLT2抑制剂已经进入临床评价后期。
  • [1] Wright EM,Hirayama BA,Loo DF.Active sugar transport in health and disease[J].Intern Med,2007,261:32.
    [2] Kanai Y,Lee WS,You G,et al.The human kidney low affinity Na/glucose cotransporter SGLT2: delineation of the major renal reabsorptive mechanism for D-glucose[J].Clin Investig,1994,93:397.
    [3] Van den Heuvel LP,Assink K,Willemsen M,et al.Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2) [J].Hum Genet,2002,111:544.
    [4] Calado J,Soto K,Clemente C,et al.Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria[J].Hum Genet,2004, 114:314.
    [5] Pajor A,Wright EM.Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family[J].Biol Chem,1992,267:3557.
    [6] Wright EM.Renal Na+-glucose cotransporters[J].Am J Physiol,2001,280:F10.
    [7] Turk E,Zabel B,Mundlos S,et al.Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter[J].Nature,1991,350:354.
    [8] Pajor AM,Randolph KM,Kerner SA,et al.Inhibitor binding in the human renal low-and high-affinity Na+/glucose cotransporters[J].J Pharmacol Exp Ther,2008,324:985.
    [9] Ehrenkranz JRL,Lewis NG,Kahn CR,et al.Phlorizin: a review[J].Diabetes Metab Res Rev,2005,21:31.
    [10] Oku A,Ueta K,Arakawa K,et al.T-1095, an inhibitor of renal Na+- glucose cotransporters, may provide a novel approach to treating diabetes[J].Diabetes,1999, 48:1794.
    [11] Adachi T,Yasuda K,Okamoto Y,et al.T-1095, renal Na+-glucose transporter inhibitor, improves hyperglycemia in streptozotocin induced diabetic rats[J].Metabolism,2000,49:990.
    [12] Katsuno K,Fujimori Y,Takemura Y,et al.Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level[J].Pharmacol Exp Ther,2007,320:323.
    [13] Hussey EK,Clark RV,Amin DM,et al.Early clinical studies to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of sergliflozin, a novel inhibitor of renal glucose reabsorption, in healthy volunteers and subjects with type 2 diabetes mellitus[J].Diabetes,2007,56 (Suppl 1):189.
    [14] Fujimori Y,Katsuno K,Nakashima I,et al.Remogliflozin etabonate, in a novel category of selective low-affinity/high-capacity sodium glucose cotransporter (SGLT-2) inhibitors, exhibits antidiabetic efficacy in rodent models[J].Pharmacol Exp Ther,2008,327:268.
    [15] Wei M,Bruce AE,Alexandra AN,et al.Discovery of dapagliflozin: A potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes[J].J Med Chem,2008,51(5):1145.
    [16] Komoroski B,Vachharajani N,Boulton D,et al.Dapagliflozin, a Novel SGLT2 Inhibitor, Induces Dose-Dependent Glucosuria in Healthy Subjects[J].Clin Pharmacol Ther,2009,85:520.
    [17] Komoroski B,Vachharajani N,Feng Y,et al.Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus[J].Clin Pharmacol Ther,2009,85:513.
    [18] List JF,Woo V,Morales E,et al.Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes mellitus[J].Diabetes Care,2009,32:650.
    [19] Calado J,Loeffler J,Sakalliouglu O,et al.Familial renal glucosuria: SGLC5A2 mutation analysis and evidence of salt-wasting[J].Kidney Int,2006,69:852.
  • [1] 陈春娟, 郑志新, 李骊.  平喘方联合孟鲁司特钠治疗儿童支气管哮喘患者的临床疗效观察 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202405035
    [2] 崔亚玲, 吴琼, 马良煜, 胡北, 姚东, 许子华.  肝素钠肌醇烟酸酯乳膏中肌醇烟酸酯皮肤药动学研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404006
    [3] 石晓萍, 吕迁洲, 李晓宇, 许青.  泊沙康唑对比伏立康唑经验治疗或诊断驱动治疗免疫功能低下患者侵袭性霉菌病的成本-效果分析 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202401050
    [4] 陈静, 何瑞华, 翁月, 徐熠, 刘静, 黄瑾.  基于网络药理学和分子对接技术探究定清片活性成分治疗白血病的作用机制 . 药学实践与服务, 2024, 42(11): 479-486. doi: 10.12206/j.issn.2097-2024.202401073
    [5] 张广雨, 杜晶, 刘梦珍, 朱丹妮, 闫慧, 刘冲.  新斯的明与山莨菪碱联合应用对肺型氧中毒的保护作用及其机制的研究 . 药学实践与服务, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
    [6] 刘依秦, 王超群, 邱娇娜.  胆宁片预处理在糖尿病患者结肠镜检查前的应用效果分析 . 药学实践与服务, 2024, 42(9): 407-410. doi: 10.12206/j.issn.2097-2024.202407037
    [7] 杨媛媛, 安晓强, 许佳捷, 江键, 梁媛媛.  正极性驻极体联合5-氟尿嘧啶对瘢痕成纤维细胞生长抑制的协同作用 . 药学实践与服务, 2024, 42(6): 244-247. doi: 10.12206/j.issn.2097-2024.202310027
    [8] 毛智毅, 王筱燕, 陈晓颖, 汤逸斐.  度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
    [9] 徐飞, 陈瑾, 鲁育含, 李志勇.  肠道菌群参与糖尿病肾病的机制研究进展 . 药学实践与服务, 2024, 42(5): 181-184, 197. doi: 10.12206/j.issn.2097-2024.202312023
    [10] 刘汝雄, 杨万镇, 涂杰, 盛春泉.  铁死亡调控蛋白GPX4的小分子抑制剂研究进展 . 药学实践与服务, 2024, 42(9): 375-378. doi: 10.12206/j.issn.2097-2024.202312075
  • 加载中
计量
  • 文章访问数:  3014
  • HTML全文浏览量:  299
  • PDF下载量:  157
  • 被引次数: 0
出版历程
  • 收稿日期:  2010-11-09
  • 修回日期:  2011-02-22

SGLT2抑制剂治疗糖尿病研究进展

摘要: 近年来,钠-葡萄糖协同转运蛋白2(type 2 sodium glucose co-transporters,SGLT2)抑制剂作为一种新型的治疗糖尿病药物成为研究热点。SGLT2在肾近端小管葡萄糖重吸收中起着非常重要的作用;抑制肾脏SGLT2可以促进Ⅱ型糖尿病人尿糖的排泄,使其血糖恢复正常而不会有低血糖的风险。临床实验表明,SGLT2抑制剂对Ⅱ型糖尿病的治疗效果明显,且具有降低体重、无低血糖风险等优点,目前,许多SGLT2抑制剂已经进入临床评价后期。

English Abstract

丁海峰, 曹永兵, 安毛毛, 贾鑫明, 姜远英. SGLT2抑制剂治疗糖尿病研究进展[J]. 药学实践与服务, 2011, 29(2): 89-92,116.
引用本文: 丁海峰, 曹永兵, 安毛毛, 贾鑫明, 姜远英. SGLT2抑制剂治疗糖尿病研究进展[J]. 药学实践与服务, 2011, 29(2): 89-92,116.
DING Hai-feng, CAO Yong-bing, AN Mao-mao, JIA Xin-ming, JIANG Yuan-ying. Research on type 2 sodium glucose co-transporters in diabetes treatment[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 89-92,116.
Citation: DING Hai-feng, CAO Yong-bing, AN Mao-mao, JIA Xin-ming, JIANG Yuan-ying. Research on type 2 sodium glucose co-transporters in diabetes treatment[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 89-92,116.
参考文献 (19)

目录

    /

    返回文章
    返回