黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

李小宁; 卫新国; 尚云; 卫洪昌; 朱晓梅; 孙平龙; 严世芸

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸

文章导航 > 药学实践与服务 > 2001 > (5): 270-272

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

引用本文:

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

LI Xiao-ning, WEI Xin-guo, SHANG Yun, WEI Hong-chang, ZHU Xiao-mei, SUN Ping-long, YAN Shi-yun. Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 270-272.

Citation:

LI Xiao-ning, WEI Xin-guo, SHANG Yun, WEI Hong-chang, ZHU Xiao-mei, SUN Ping-long, YAN Shi-yun. Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 270-272.

黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

1.
上海市南汇县光明中医医院, 上海201300
2.
上海中医药大学, 上海200032

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

1.
Guangming Hospital of TCM, Nanhui, Shanghai 201300, China
2.
Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China

摘要: 目的探讨黄芪保心汤地实验性急性心肌缺血大鼠血浆内皮素(ET)、降钙素基因相关肽(CGRP)水平的影响。方法 44只大白鼠随机分为4组:假手术组,模型对照组,黄芪保心汤组,复方丹参滴丸组。结扎左冠状动脉前降支造成急性心肌缺血模型,观察3h后,从腹主动脉取血检测血浆ET、CGRP水平。结果黄芪保心汤组,能显着降低血浆ET含量(P<0.001),升高血浆GGRP水平(P<0.01)。结论以益气活血祛痰化浊为主的黄芪保心汤有调节急性心肌缺血时血浆ET、CGRP水平失衡的作用,改善心肌缺血、缺氧状态,减少心肌缺血损伤,且作用优于复方丹参滴丸。
- 急性实验性心肌缺血 /
- 内皮素 /
- 降钙素基因相关肽 /
- 黄芪保心汤
Abstract: OBJECTIVE To investigate the influence of Astragalus heart keeping decoction on the level of plasma endothelin(El') and calcitonin gene related peptide (CGRP) in rats during the coronary artery occlusion in vivo. METHODS 44 rats were devided randomly into the sham ligation group, the control group, the Astragalus heart -keeping decoction (AHKD) group, the Composite Danshen Droplet Pills (CDDP) group. Various groups of the rats were fed with water, AHKD, CDDP for four weeks, respectively. And then rats were subjected to left anterior descending artery occlusion for 3 hour. for the determination of plasma El' and CGRP. RESULTS the level of plasma ET was lower on average in the group of AHKD than in the control group(P<0.01),and in comparison with the control group there was no significant difference in plasma ET in the group of CDDP (P<0.05). The level of plasma CGRP in the AHKD and CDDP groups was higher than that of plasma CGRP in the control group (P<0.01). CONCLUSION AHKD and CDDP have the function to regulate the level of plasma ET and CGRP in rats during the coronary artery occlusion, to improve myocardial ischemia,and that the efficacy of AHKD is superior to that of CDDP.
- astragalus heart-keeping decoction /
- acute myocardial infarction /
- experimental study /
- ET

[1]	杨嘉宁, 赵一颖, 肖伟. 七味脂肝方对非酒精性脂肪性肝炎动物模型的药效学评价 . 药学实践与服务, 2024, 42(9): 389-398. doi: 10.12206/j.issn.2097-2024.202404096
[2]	迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛. 负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034
[3]	戴菲菲, 傅翔, 陈琼年, 俞苏纯. 上海某二级医院革兰阴性菌流行特征的回顾性分析 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202305005
[4]	王耀振, 徐灿, 吕顺莉, 田泾, 张东炜. 钾离子竞争性酸阻滞剂的药学特征研究进展 . 药学实践与服务, 2024, 42(7): 278-284. doi: 10.12206/j.issn.2097-2024.202306040
[5]	张晶晶, 索丽娜, 郑兆红. 89例细菌性肝脓肿的临床特征及抗感染治疗分析 . 药学实践与服务, 2024, 42(6): 267-272. doi: 10.12206/j.issn.2097-2024.202302039
[6]	徐璐璐, 刘爱军. 丹参白术方“异病同治”冠心病、血管性痴呆、特发性膜性肾病的网络药理学作用机制研究 . 药学实践与服务, 2024, 42(12): 1-8. doi: 10.12206/j.issn.2097-2024.202312027
[7]	刘丽艳, 余小翠, 孙传铎. 纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
[8]	张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英. 二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
[9]	冯志惠, 邓仪卿, 叶冰, 安培, 张宏, 张海军. 雀梅藤石油醚提取物诱导三阴性乳腺癌细胞凋亡的实验研究 . 药学实践与服务, 2024, 42(6): 253-259. doi: 10.12206/j.issn.2097-2024.202311055
[10]	黄韵, 张正银, 金英, 郑怡菁, 李铁军, 孙莉莉. 耐碳青霉烯类肺炎克雷伯菌及大肠埃希菌临床分离株耐药性及耐药基因分析 . 药学实践与服务, 2024, 42(10): 439-444. doi: 10.12206/j.issn.2097-2024.202309059
[11]	丁华敏, 郭羽晨, 秦春霞, 宋志兵, 孙莉莉. 消风止痒颗粒通过降低白三烯水平对小鼠特应性皮炎急性瘙痒的治疗作用研究 . 药学实践与服务, 2024, 42(5): 211-216. doi: 10.12206/j.issn.2097-2024.202306031
[12]	何静, 安晔, 张朝绅. 复方黑参滴丸与复方黑参丸药效学实验比较研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404009
[13]	王雪莲, 郑斯莉, 李志勇, 罗亨宇, 缪朝玉. 全身过表达人METRNL基因小鼠模型的构建与验证 . 药学实践与服务, 2024, 42(5): 198-202, 222. doi: 10.12206/j.issn.2097-2024.202311014
[14]	姚瑞阳, 于海征, 李耀盺, 张磊. 丹参FBXL 基因家族的鉴定和表达模式分析 . 药学实践与服务, 2024, 42(11): 461-470. doi: 10.12206/j.issn.2097-2024.202407034
[15]	张莲卿, 骆岩, 杨提, 姚佳晨, 李文艳. 基于FAERS数据库的艾塞那肽微球不良事件信号挖掘与研究 . 药学实践与服务, 2024, 42(10): 445-450. doi: 10.12206/j.issn.2097-2024.202403057
[16]	岳春华, 贲永光, 王海桥. 基于NLRP1炎症小体探讨百合知母汤抗抑郁的作用机制 . 药学实践与服务, 2024, 42(8): 325-333. doi: 10.12206/j.issn.2097-2024.202401033
[17]	景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞. 黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004
[18]	孙丹倪, 黄勇, 张嘉宝, 王培. 代谢相关脂肪性肝病的无创诊断与药物治疗 . 药学实践与服务, 2024, 42(10): 411-418. doi: 10.12206/j.issn.2097-2024.202403049
[19]	唐淑慧, 凤美娟, 薛智霞, 鲁桂华. 帕博利珠单抗治疗所致免疫相关不良反应与中医体质的相关性研究 . 药学实践与服务, 2024, 42(5): 217-222. doi: 10.12206/j.issn.2097-2024.202311029
[20]	桂明珠, 李静, 李志玲. 儿童伏立康唑的血药浓度与CYP2C19、CYP2C9和CYP3A5基因多态性的相关性研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402020

点击查看大图

计量

文章访问数: 2499
HTML全文浏览量: 185
PDF下载量: 391
被引次数: 0

黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

1. 上海市南汇县光明中医医院, 上海201300

2. 上海中医药大学, 上海200032

收稿日期: 2001-04-24

关键词:

急性实验性心肌缺血 /

内皮素 /

降钙素基因相关肽 /

黄芪保心汤

摘要: 目的探讨黄芪保心汤地实验性急性心肌缺血大鼠血浆内皮素(ET)、降钙素基因相关肽(CGRP)水平的影响。方法 44只大白鼠随机分为4组:假手术组,模型对照组,黄芪保心汤组,复方丹参滴丸组。结扎左冠状动脉前降支造成急性心肌缺血模型,观察3h后,从腹主动脉取血检测血浆ET、CGRP水平。结果黄芪保心汤组,能显着降低血浆ET含量(P<0.001),升高血浆GGRP水平(P<0.01)。结论以益气活血祛痰化浊为主的黄芪保心汤有调节急性心肌缺血时血浆ET、CGRP水平失衡的作用,改善心肌缺血、缺氧状态,减少心肌缺血损伤,且作用优于复方丹参滴丸。

English Abstract

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

1. Guangming Hospital of TCM, Nanhui, Shanghai 201300, China

2. Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China

Received Date: 2001-04-24

Keywords:

Abstract: OBJECTIVE To investigate the influence of Astragalus heart keeping decoction on the level of plasma endothelin(El') and calcitonin gene related peptide (CGRP) in rats during the coronary artery occlusion in vivo. METHODS 44 rats were devided randomly into the sham ligation group, the control group, the Astragalus heart -keeping decoction (AHKD) group, the Composite Danshen Droplet Pills (CDDP) group. Various groups of the rats were fed with water, AHKD, CDDP for four weeks, respectively. And then rats were subjected to left anterior descending artery occlusion for 3 hour. for the determination of plasma El' and CGRP. RESULTS the level of plasma ET was lower on average in the group of AHKD than in the control group(P<0.01),and in comparison with the control group there was no significant difference in plasma ET in the group of CDDP (P<0.05). The level of plasma CGRP in the AHKD and CDDP groups was higher than that of plasma CGRP in the control group (P<0.01). CONCLUSION AHKD and CDDP have the function to regulate the level of plasma ET and CGRP in rats during the coronary artery occlusion, to improve myocardial ischemia,and that the efficacy of AHKD is superior to that of CDDP.

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

引用本文:

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

Citation:

LI Xiao-ning, WEI Xin-guo, SHANG Yun, WEI Hong-chang, ZHU Xiao-mei, SUN Ping-long, YAN Shi-yun. Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 270-272.

全文HTML

下载: 全尺寸图片幻灯片

返回文章

用微信扫码二维码

分享至好友和朋友圈

主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

电话: （021）81871324,81871397 E-mail: [email protected]

网站备案号沪ICP备05003363号-1

本系统由北京仁和汇智信息技术有限公司开发

留言板

黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

计量

出版历程

黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

1. 上海市南汇县光明中医医院, 上海201300 2. 上海中医药大学, 上海200032

English Abstract

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

1. Guangming Hospital of TCM, Nanhui, Shanghai 201300, China 2. Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China

全文HTML

目录

1. 上海市南汇县光明中医医院, 上海201300

2. 上海中医药大学, 上海200032

1. Guangming Hospital of TCM, Nanhui, Shanghai 201300, China

2. Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China