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右美托咪定用于神经阻滞的研究进展

陈琪,  刘兴,  刘红亮

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文章导航 > 药学实践与服务  > 2018 >  36(4): 289-292
陈琪, 刘兴, 刘红亮. 右美托咪定用于神经阻滞的研究进展[J]. 药学实践与服务, 2018, 36(4): 289-292. doi: 10.3969/j.issn.1006-0111.2018.04.001
引用本文: 陈琪, 刘兴, 刘红亮. 右美托咪定用于神经阻滞的研究进展[J]. 药学实践与服务, 2018, 36(4): 289-292. doi: 10.3969/j.issn.1006-0111.2018.04.001
shu
CHEN Qi, LIU Xing, LIU Hongliang. Research progress of dexmedetomidine in nerve block[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 289-292. doi: 10.3969/j.issn.1006-0111.2018.04.001
Citation: CHEN Qi, LIU Xing, LIU Hongliang. Research progress of dexmedetomidine in nerve block[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 289-292. doi: 10.3969/j.issn.1006-0111.2018.04.001
shu

右美托咪定用于神经阻滞的研究进展

doi: 10.3969/j.issn.1006-0111.2018.04.001

  • 重庆大学附属肿瘤医院/重庆市肿瘤研究所/重市市肿瘤医院, 重庆 400030

基金项目: 重庆市科学技术委员会重点项目（cstc2017jcyj BX0043）

Research progress of dexmedetomidine in nerve block

  • Chongqing University Affiliated Cancer Hospital/Chongqing Cancer Institue/Chongqing Cancer Hospital, Chongqing 400030, China

  • 摘要: 右美托咪定（Dex）是一种高选择性的α2肾上腺素能受体激动剂，目前作为局麻药的辅助用药在神经阻滞中取得了良好的临床效果，可缩短局麻药的起效时间、延长镇痛时效并减少术后镇痛药的使用，同其他局麻药辅助药物相比，右美托咪定可提供更优的镇痛效果和时程，以及较少的不良反应。
    Abstract: Dexmedetomidine(Dex) is a specific alpha-2-adrenergic agonist which was widely used in nerve blocks as an adjuvant to local anesthetic(LA) in order to shortening the onset time, prolonging the analgesic effect and reducing the postoperative analgesic consumption.When compared with other adjuvant to LA,Dex was effective in providing better analgesia efficacy with fewer side effects.
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    [16] ALMARAKBI WA, KAKI AM.Addition of dexmedetomidine to bupivacaine in transversus abdominis plane block potentiates post-operative pain relief among abdominal hysterectomy patients:A prospective randomized controlled trial[J]. Saudi J Anaesth,2014,8(2):161-166.
    [17] KIVIST KT, KALLIO A, NEUVONEN PJ.Pharmacokinetics and pharmacodynamics of transdermal dexmedetomidine[J]. Eur J Clin Pharmacol,1994;46(4):345-349.
    [18] BRUMMETT CM, NORAT MA,PALMISANO JM,et al. Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat[J].Anesthesiology,2008; 109(3):502-511.
    [19] KONAKCI S,ADANIR T,YILMAZ G,et al. The efficacy and neurotoxicity of dexmedetomidine administered via the epidural route[J]. Eur J Anaesthesiol,2008,25(5):403-409.
    [20] ANDERSEN JH, GREVSTAD U, SIEGEL H,et al. Does dexmedetomidine have a perineural mechanism of action when used as an adjuvant to ropivacaine? A paired, blinded, randomized trial in healthy volunteers[J].Anesthesiology,2017;126(1):66-73.
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    [27] BUTTERWORTH JF 5TH,STRICHARTZ GR. The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers[J]. Anesth Analg,1993,76(2):295-301.
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    [29] 李金玉,葛东建,祁宾,等. 不同剂量右美托咪定混合罗哌卡因用于臂丛神经阻滞的效果[J]. 中华麻醉学杂志,2013,33(6):711-713.
    [30] MARHOFER P, BRUMMETT CM. Safety and efficiency of dexmedetomidine as adjuvant to local anesthetics[J]. Curr Opin Anaesthesiol,2016;29(5):632-637.
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  • 收稿日期:  2017-06-20
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右美托咪定用于神经阻滞的研究进展

doi: 10.3969/j.issn.1006-0111.2018.04.001
  • 重庆大学附属肿瘤医院/重庆市肿瘤研究所/重市市肿瘤医院, 重庆 400030
    • 基金项目:  重庆市科学技术委员会重点项目（cstc2017jcyj BX0043）
  • 收稿日期: 2017-06-20
  • 修回日期: 2018-01-20

摘要: 右美托咪定（Dex）是一种高选择性的α2肾上腺素能受体激动剂，目前作为局麻药的辅助用药在神经阻滞中取得了良好的临床效果，可缩短局麻药的起效时间、延长镇痛时效并减少术后镇痛药的使用，同其他局麻药辅助药物相比，右美托咪定可提供更优的镇痛效果和时程，以及较少的不良反应。

English Abstract

陈琪, 刘兴, 刘红亮. 右美托咪定用于神经阻滞的研究进展[J]. 药学实践与服务, 2018, 36(4): 289-292. doi: 10.3969/j.issn.1006-0111.2018.04.001
引用本文: 陈琪, 刘兴, 刘红亮. 右美托咪定用于神经阻滞的研究进展[J]. 药学实践与服务, 2018, 36(4): 289-292. doi: 10.3969/j.issn.1006-0111.2018.04.001
shu
CHEN Qi, LIU Xing, LIU Hongliang. Research progress of dexmedetomidine in nerve block[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 289-292. doi: 10.3969/j.issn.1006-0111.2018.04.001
Citation: CHEN Qi, LIU Xing, LIU Hongliang. Research progress of dexmedetomidine in nerve block[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 289-292. doi: 10.3969/j.issn.1006-0111.2018.04.001
shu

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