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肠道微生态与炎症性肠病

何丽娟,  张军东,  安毛毛,  姜远英

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文章导航 > 药学实践与服务  > 2015 >  33(5): 385-388,422
何丽娟, 张军东, 安毛毛, 姜远英. 肠道微生态与炎症性肠病[J]. 药学实践与服务, 2015, 33(5): 385-388,422. doi: 10.3969/j.issn.1006-0111.2015.05.001
引用本文: 何丽娟, 张军东, 安毛毛, 姜远英. 肠道微生态与炎症性肠病[J]. 药学实践与服务, 2015, 33(5): 385-388,422. doi: 10.3969/j.issn.1006-0111.2015.05.001
shu
HE Lijuan, ZHANG Jundong, AN Maomao, JIANG Yuanying. Gut microbiota and inflammatory bowel disease[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 385-388,422. doi: 10.3969/j.issn.1006-0111.2015.05.001
Citation: HE Lijuan, ZHANG Jundong, AN Maomao, JIANG Yuanying. Gut microbiota and inflammatory bowel disease[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 385-388,422. doi: 10.3969/j.issn.1006-0111.2015.05.001
shu

肠道微生态与炎症性肠病

doi: 10.3969/j.issn.1006-0111.2015.05.001
  • 1.

    第二军医大学药学院新药研究中心, 上海 200433

  • 2.

    同济大学附属第十人民医院, 上海 200072

  • 3.

    同济大学医学院, 上海 200092

Gut microbiota and inflammatory bowel disease

  • 1.

    New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China

  • 3.

    School of Medicine, Tongji University, Shanghai 200092, China

  • 摘要: 炎症性肠病(inflammatory bowel disease,IBD)是一组病因未明、发病机制亦不明确的慢性肠道炎症性疾病,主要包括克罗恩病(Crohn's disease,CD)和溃疡性结肠炎(ulcerative colitis,UC)。近几十年的研究结果认为,其发病是环境、易感基因和肠道微生态3个要素相互作用的结果,且这些要素使IBD成为一种适合研究宿主与肠道微生物相互作用的高优先平台。最近,肠道菌群的图谱分析将IBD的发病机制与菌群各组成部分特征的改变相联系,进一步支持"肠道微生物和宿主相互作用的改变能形成IBD"这一观点。该文回顾性分析有关IBD患者体内微生物的研究文献,综述肠道微生态失衡对IBD的多方面影响,以动物模型和临床验证资料阐述不同的治疗方法改善肠道微生态变化的最新进展。
    Abstract: Inflammatory bowel disease is a chronic inflammation of the intestinal tract, which comprises two primary forms of Crohn's disease(CD) and ulcerative colitis(UC). Decades of studies have revealed that environmental factors, susceptibility genes, and gut microbiota are considered as the major determinants for the induction of IBD. The combination of factors has made IBD as an appropriate and a high-priority platform for studying host-microbiome interactions. More recently, profiling studies of the intestinal microbe have associated pathogenesis of IBD with characteristic alterations in the composition of the intestinal microbiota,reinforcing the viewpoint that IBD results from the altered interplays between the host and intestinal microbe. the studies of the gut flora in IBD were reviewed andthe multiple effects of intestinal microbiota-dysfunction on the IBD were described.The progress of intestinal microbiota alterations with different therapeutic methods in animal models and clinic trials were provided.
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  • 收稿日期:  2014-11-13
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肠道微生态与炎症性肠病

doi: 10.3969/j.issn.1006-0111.2015.05.001
  • 1. 第二军医大学药学院新药研究中心, 上海 200433
  • 2. 同济大学附属第十人民医院, 上海 200072
  • 3. 同济大学医学院, 上海 200092
  • 收稿日期: 2014-11-13
  • 修回日期: 2015-03-17

摘要: 炎症性肠病(inflammatory bowel disease,IBD)是一组病因未明、发病机制亦不明确的慢性肠道炎症性疾病,主要包括克罗恩病(Crohn's disease,CD)和溃疡性结肠炎(ulcerative colitis,UC)。近几十年的研究结果认为,其发病是环境、易感基因和肠道微生态3个要素相互作用的结果,且这些要素使IBD成为一种适合研究宿主与肠道微生物相互作用的高优先平台。最近,肠道菌群的图谱分析将IBD的发病机制与菌群各组成部分特征的改变相联系,进一步支持"肠道微生物和宿主相互作用的改变能形成IBD"这一观点。该文回顾性分析有关IBD患者体内微生物的研究文献,综述肠道微生态失衡对IBD的多方面影响,以动物模型和临床验证资料阐述不同的治疗方法改善肠道微生态变化的最新进展。

English Abstract

何丽娟, 张军东, 安毛毛, 姜远英. 肠道微生态与炎症性肠病[J]. 药学实践与服务, 2015, 33(5): 385-388,422. doi: 10.3969/j.issn.1006-0111.2015.05.001
引用本文: 何丽娟, 张军东, 安毛毛, 姜远英. 肠道微生态与炎症性肠病[J]. 药学实践与服务, 2015, 33(5): 385-388,422. doi: 10.3969/j.issn.1006-0111.2015.05.001
shu
HE Lijuan, ZHANG Jundong, AN Maomao, JIANG Yuanying. Gut microbiota and inflammatory bowel disease[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 385-388,422. doi: 10.3969/j.issn.1006-0111.2015.05.001
Citation: HE Lijuan, ZHANG Jundong, AN Maomao, JIANG Yuanying. Gut microbiota and inflammatory bowel disease[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 385-388,422. doi: 10.3969/j.issn.1006-0111.2015.05.001
shu

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