摘要:
目的 探讨布拉酵母菌对婴幼儿肺炎继发抗生素相关腹泻(AAD)的防治作用。 方法 选择1个月至3岁婴幼儿肺炎住院患者302例,均静脉应用抗菌药物且连续治疗>5 d,排除慢性胃肠道疾病,随机分为对照组(A组,60例)、布拉酵母菌治疗组(B组,92例)和布拉酵母菌预防组(C组,150例)。入选患儿在抗感染治疗的同时, C组加用布拉酵母菌,B组继发腹泻后加用布拉酵母菌,观察各组患儿AAD的发生情况,比较分析各组疗效。 结果 C组患儿AAD发生率明显低于A、B组患儿;各组患儿继发腹泻严重程度差异无统计学意义(P>0.05);腹泻持续时间差异有统计学意义(P<0.001),其中布拉酵母菌预防组腹泻持续时间最短,治疗组次之,对照组最长;抗腹泻总有效率差异有统计学意义(P<0.05),A组抗腹泻总有效率不如C组,尚不能认为A组与B组、B组与C组间抗腹泻疗效有差别。 结论 婴幼儿肺炎继发AAD后,应用布拉酵母菌,可缩短腹泻病程;若预防性应用布拉酵母菌不仅能降低AAD的发病率,还能缩短腹泻病程,提高AAD治疗疗效,值得在临床工作中推广预防应用。
Abstract:
Objective To investigate the therapeutic effect of Saccharomyces boulardii on antibiotics associated diarrhea(AAD)in infant pneumonia. Methods 302 hospitalized infant patients (1 month-3 years) with pneumonia but without gastroenteric disease were selected, and antibiotics were administrated intravenously at least 5 continuous days for each patient. Patients were all given antibiotics and randomly divided into three groups: control group with no Saccharomyces boulardii administration (group A, 60 cases);Saccharomyces boulardii were applied as addition on the occurrence of diarrhea (group B, 92 cases), and Saccharomyces boulardii and antibiotics were co-administrated (group C, 150 cases). Incidences of AAD in all groups were carefully examined and differences of therapeutic effect between groups were compared and analyzed. Results The incidence of AAD in Group C was significantly lower than that in other groups. In term of diarrhea severity, no significant difference was observed in all groups (P>0.05). However, duration of diarrhea showed significant different between groups (P<0.001): group A with the longest duration and group C with the shortest. The results indicated that the total efficiency of anti-diarrhea in group C was significantly higher than that in control group (P<0.05).However, group B presented no significant difference compared with neither control group nor group C in term of therapeutic effect on diarrhea. Conclusion Administration of Saccharomyces boulardii Sachets could shorten the duration of diarrhea on the occurrence of AAD in infant pneumonia. According to our results, Saccharomyces boulardii was effective in both preventing the development of AAD and shortening duration of diarrhea, and therefore improved therapeutic effect on ADD.
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