脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用

孙宁玲; 汪涛; 袁本利; 李慧梁; 陆国才; 张卫东; 张川; 袁伯俊

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脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用

孙宁玲, 汪涛, 袁本利, 李慧梁, 陆国才, 张卫东, 张川, 袁伯俊

文章导航 > 药学实践与服务 > 2008 > (1): 23-27,50

孙宁玲, 汪涛, 袁本利, 李慧梁, 陆国才, 张卫东, 张川, 袁伯俊. 脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用[J]. 药学实践与服务, 2008, (1): 23-27,50.

引用本文:

孙宁玲, 汪涛, 袁本利, 李慧梁, 陆国才, 张卫东, 张川, 袁伯俊. 脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用[J]. 药学实践与服务, 2008, (1): 23-27,50.

SUN Ning-ling, WANG Tao, YUAN Ben-li, LI Hui-liang, LU Guo-cai, ZHANG Wei-dong, ZHANG Chuan, YUAN Bo-jun. Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 23-27,50.

Citation:

SUN Ning-ling, WANG Tao, YUAN Ben-li, LI Hui-liang, LU Guo-cai, ZHANG Wei-dong, ZHANG Chuan, YUAN Bo-jun. Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 23-27,50.

脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用

1.
北京军事医学科学院毒物药物研究所,北京100850
2.
上海第二军医大学新药评价中心,上海200433
3.
上海第二军医大学药学院天然药物化学教研室,上海200433

基金项目: 国家自然科学基金

Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice

1.
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
2.
Center for New Drug Evaluation, Institute of Basic Medical Science, Second Military Medical University, Shanghai 200433, China
3.
Department of Natural Medicinal Chemistry, Second Military Medical University, Shanghai 200433, China

摘要: 目的: 研究脱氢卡维汀(YHL-DC)对四氯化碳(CCl4)致小鼠急性肝损伤的影响。 方法: YHL-DC预防和治疗给药后观察其对CCl4致急性肝损伤小鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)和总胆红素(TBIL)的影响,并对肝脏进行了病理组织学及电镜观察。 结果: YHL-DC预防和治疗给药均能显著降低急性肝损伤小鼠ALT、AST和TBIL的升高,有效减轻CCl4引起的小鼠肝细胞变性、坏死、炎性细胞浸润和肝细胞超微结构的破坏。 结论: YHL-DC对四氯化碳致小鼠急性肝损伤具有保护作用。
- 脱氢卡维汀 /
- 岩黄连 /
- 四氯化碳 /
- 肝损伤
Abstract: Objective: To investigate the effects of Dehydrocavidine (YHL-DC) on carbon tetrachloride (CCl4) induced acute liver injury in mice. Methods: The mice were pre-treatment with YHL-DC prior to the administration of CCl4 and post-treatment with YHL-DC after the administration of CCl4, and the changes of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) in these mice were examined respectively. Histopathology changes of liver were also observed under both light and electron microscope. Results: Pre-treatment and post-treatment with YHL-DC significantly prevented increase in serum enzymatic activities of ALT, AST and TBIL in a dose-dependent manner. Hepatocyte degeneration and necrosis, infiltration of inflammatory cells and destruction of hepatocyte ultrastructure appeared in carbon tetrachloride induced acute injured liver in mice, while extenuations were observed in both pre-and post-treatment groups administered with YHL-DC. Conclusion: The results suggest that YHL-DC has a potent hepatoprotective action on CCl4 induced acute liver injury in mice.
- Dehydrocavidine /
- corydalis saxicola bunting /
- carbon tetrachloride /
- liver injury

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脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用

1. 北京军事医学科学院毒物药物研究所,北京100850

2. 上海第二军医大学新药评价中心,上海200433

3. 上海第二军医大学药学院天然药物化学教研室,上海200433

基金项目: 国家自然科学基金

收稿日期: 2007-08-28
修回日期: 2007-09-03

关键词:

脱氢卡维汀 /

岩黄连 /

四氯化碳 /

肝损伤

摘要: 目的: 研究脱氢卡维汀(YHL-DC)对四氯化碳(CCl4)致小鼠急性肝损伤的影响。 方法: YHL-DC预防和治疗给药后观察其对CCl4致急性肝损伤小鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)和总胆红素(TBIL)的影响,并对肝脏进行了病理组织学及电镜观察。 结果: YHL-DC预防和治疗给药均能显著降低急性肝损伤小鼠ALT、AST和TBIL的升高,有效减轻CCl4引起的小鼠肝细胞变性、坏死、炎性细胞浸润和肝细胞超微结构的破坏。 结论: YHL-DC对四氯化碳致小鼠急性肝损伤具有保护作用。

English Abstract

Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice

1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China

2. Center for New Drug Evaluation, Institute of Basic Medical Science, Second Military Medical University, Shanghai 200433, China

3. Department of Natural Medicinal Chemistry, Second Military Medical University, Shanghai 200433, China

Received Date: 2007-08-28
Rev Recd Date: 2007-09-03

Keywords:

Abstract: Objective: To investigate the effects of Dehydrocavidine (YHL-DC) on carbon tetrachloride (CCl4) induced acute liver injury in mice. Methods: The mice were pre-treatment with YHL-DC prior to the administration of CCl4 and post-treatment with YHL-DC after the administration of CCl4, and the changes of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) in these mice were examined respectively. Histopathology changes of liver were also observed under both light and electron microscope. Results: Pre-treatment and post-treatment with YHL-DC significantly prevented increase in serum enzymatic activities of ALT, AST and TBIL in a dose-dependent manner. Hepatocyte degeneration and necrosis, infiltration of inflammatory cells and destruction of hepatocyte ultrastructure appeared in carbon tetrachloride induced acute injured liver in mice, while extenuations were observed in both pre-and post-treatment groups administered with YHL-DC. Conclusion: The results suggest that YHL-DC has a potent hepatoprotective action on CCl4 induced acute liver injury in mice.

孙宁玲, 汪涛, 袁本利, 李慧梁, 陆国才, 张卫东, 张川, 袁伯俊. 脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用[J]. 药学实践与服务, 2008, (1): 23-27,50.

引用本文:

孙宁玲, 汪涛, 袁本利, 李慧梁, 陆国才, 张卫东, 张川, 袁伯俊. 脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用[J]. 药学实践与服务, 2008, (1): 23-27,50.

Citation:

SUN Ning-ling, WANG Tao, YUAN Ben-li, LI Hui-liang, LU Guo-cai, ZHANG Wei-dong, ZHANG Chuan, YUAN Bo-jun. Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 23-27,50.

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脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用

Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice

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脱氢卡维汀对四氯化碳致小鼠急性肝损伤的保护作用

1. 北京军事医学科学院毒物药物研究所,北京100850 2. 上海第二军医大学新药评价中心,上海200433 3. 上海第二军医大学药学院天然药物化学教研室,上海200433

English Abstract

Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice

全文HTML

目录

1. 北京军事医学科学院毒物药物研究所,北京100850

2. 上海第二军医大学新药评价中心,上海200433

3. 上海第二军医大学药学院天然药物化学教研室,上海200433