胆宁片对实验性急慢性肝损伤的保护作用

柳润辉; 陈忠梁; 李铁军; 刘晓华; 徐瑞林; 徐希科; 张川; 张卫东

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胆宁片对实验性急慢性肝损伤的保护作用

柳润辉, 陈忠梁, 李铁军, 刘晓华, 徐瑞林, 徐希科, 张川, 张卫东

文章导航 > 药学实践与服务 > 2007 > (3): 147-149

柳润辉, 陈忠梁, 李铁军, 刘晓华, 徐瑞林, 徐希科, 张川, 张卫东. 胆宁片对实验性急慢性肝损伤的保护作用[J]. 药学实践与服务, 2007, (3): 147-149.

引用本文:

柳润辉, 陈忠梁, 李铁军, 刘晓华, 徐瑞林, 徐希科, 张川, 张卫东. 胆宁片对实验性急慢性肝损伤的保护作用[J]. 药学实践与服务, 2007, (3): 147-149.

LIU Run-hui, CHEN Zhong-liang, LI Tie-jun, LIU Xiao-hua, XU Rui-lin, XU Xi-ke, ZHANG Chuan, ZHANG Wei-dong. The protective effects of Danning tablet on experimental liver injury in mice and rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 147-149.

Citation:

LIU Run-hui, CHEN Zhong-liang, LI Tie-jun, LIU Xiao-hua, XU Rui-lin, XU Xi-ke, ZHANG Chuan, ZHANG Wei-dong. The protective effects of Danning tablet on experimental liver injury in mice and rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 147-149.

胆宁片对实验性急慢性肝损伤的保护作用

1.
第二军医大学药学院天然药物化学教研室,上海200433;
2.
上海和黄药业有限公司研发部,上海200331;
3.
第二军医大学药学院药理学教研室,上海200433

基金项目: 上海市科技发展基金(胆宁片物质基础和作用机理研究04DZ19857)资助项目

The protective effects of Danning tablet on experimental liver injury in mice and rats

1.
Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, China;
2.
Shanghai Hehuang Pharmaceutical Company Limited, Shanghai 200331,China;
3.
Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 目的:研究胆宁片对实验性小鼠急性肝损伤预防作用,及对大鼠慢性肝损伤的预防和治疗作用。方法:分别用D-氨基半乳糖和四氯化碳复制小鼠急性肝损伤和大鼠慢性肝损伤模型,检测小鼠和大鼠血清谷草转氨酶(AST)和谷丙转氨酶(ALT)的改变,观察胆宁片对大鼠血清总蛋白、白蛋白、A/G的影响、同时观察肝脏病理学改变。结果:胆宁片可明显抑制D-氨基半乳糖和四氯化碳引起的ALT、AST升高(P<0.05或P<0.01);可显著升高四氯化碳引起的血清总蛋白和白蛋白含量降低(P<0.05或P<0.01);肝脏病理组织学检查显示胆宁片可减轻肝细胞脂肪变性程度和纤维化程度。结论:胆宁片对小鼠D-氨基半乳糖急性肝损伤有较好的保护作用,对四氯化碳所致大鼠慢性肝损伤有一定的预防及治疗作用。
- 胆宁片 /
- 肝损伤 /
- 谷草转氨酶 /
- 谷丙转氨酶 /
- 保护作用
Abstract: Objective:To study the protective effects of Danning tablet on CCl4 and D-galactosamine induced liver injury in mice and rats.Methods:Mice and rats were induced acute and chronic liver injury by administrated with D-galactosamine and CCl4 respectively,and the activities of glutamic-oxal(o)acetic transaminase(AST) and glutamate-pyruvate transaminase(ALT) in plasma were detected,influence on contents of the serum total protein,albumin and A/G were observed, histopathologic examination was employed to observe the liver injury. Results:Danning tablet can significantly inhibited the activities of ALT and AST which were rised by CCl4 and D-galactosamine(P<0.05 or P<0.01),can significantly increased the contents of the total protein, albumin which were decreased by CCl4(P<0.05 or P<0.01),Histopathologic examination show degree of fatty degeneration and fibrosis of liver cell were improved by Danning tablet.Conclusion: Danning tablet are effective in liver injuries induced by CCl4 and D-galactosamine.
- Danning tablet /
- liver injury /
- glutamic-oxal(o)acetic transaminase (AST) /
- glutamate-pyruvate transaminase (ALT) /
- protective effects

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胆宁片对实验性急慢性肝损伤的保护作用

1. 第二军医大学药学院天然药物化学教研室,上海200433;

2. 上海和黄药业有限公司研发部,上海200331;

3. 第二军医大学药学院药理学教研室,上海200433

基金项目: 上海市科技发展基金(胆宁片物质基础和作用机理研究04DZ19857)资助项目

收稿日期: 2006-04-17

关键词:

胆宁片 /

肝损伤 /

谷草转氨酶 /

谷丙转氨酶 /

保护作用

摘要: 目的:研究胆宁片对实验性小鼠急性肝损伤预防作用,及对大鼠慢性肝损伤的预防和治疗作用。方法:分别用D-氨基半乳糖和四氯化碳复制小鼠急性肝损伤和大鼠慢性肝损伤模型,检测小鼠和大鼠血清谷草转氨酶(AST)和谷丙转氨酶(ALT)的改变,观察胆宁片对大鼠血清总蛋白、白蛋白、A/G的影响、同时观察肝脏病理学改变。结果:胆宁片可明显抑制D-氨基半乳糖和四氯化碳引起的ALT、AST升高(P<0.05或P<0.01);可显著升高四氯化碳引起的血清总蛋白和白蛋白含量降低(P<0.05或P<0.01);肝脏病理组织学检查显示胆宁片可减轻肝细胞脂肪变性程度和纤维化程度。结论:胆宁片对小鼠D-氨基半乳糖急性肝损伤有较好的保护作用,对四氯化碳所致大鼠慢性肝损伤有一定的预防及治疗作用。

English Abstract

The protective effects of Danning tablet on experimental liver injury in mice and rats

1. Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, China;

2. Shanghai Hehuang Pharmaceutical Company Limited, Shanghai 200331,China;

3. Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2006-04-17

Keywords:

Danning tablet /
liver injury /
glutamic-oxal(o)acetic transaminase (AST) /
glutamate-pyruvate transaminase (ALT) /
protective effects

Abstract: Objective:To study the protective effects of Danning tablet on CCl4 and D-galactosamine induced liver injury in mice and rats.Methods:Mice and rats were induced acute and chronic liver injury by administrated with D-galactosamine and CCl4 respectively,and the activities of glutamic-oxal(o)acetic transaminase(AST) and glutamate-pyruvate transaminase(ALT) in plasma were detected,influence on contents of the serum total protein,albumin and A/G were observed, histopathologic examination was employed to observe the liver injury. Results:Danning tablet can significantly inhibited the activities of ALT and AST which were rised by CCl4 and D-galactosamine(P<0.05 or P<0.01),can significantly increased the contents of the total protein, albumin which were decreased by CCl4(P<0.05 or P<0.01),Histopathologic examination show degree of fatty degeneration and fibrosis of liver cell were improved by Danning tablet.Conclusion: Danning tablet are effective in liver injuries induced by CCl4 and D-galactosamine.

柳润辉, 陈忠梁, 李铁军, 刘晓华, 徐瑞林, 徐希科, 张川, 张卫东. 胆宁片对实验性急慢性肝损伤的保护作用[J]. 药学实践与服务, 2007, (3): 147-149.

引用本文:

柳润辉, 陈忠梁, 李铁军, 刘晓华, 徐瑞林, 徐希科, 张川, 张卫东. 胆宁片对实验性急慢性肝损伤的保护作用[J]. 药学实践与服务, 2007, (3): 147-149.

Citation:

LIU Run-hui, CHEN Zhong-liang, LI Tie-jun, LIU Xiao-hua, XU Rui-lin, XU Xi-ke, ZHANG Chuan, ZHANG Wei-dong. The protective effects of Danning tablet on experimental liver injury in mice and rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 147-149.

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胆宁片对实验性急慢性肝损伤的保护作用

The protective effects of Danning tablet on experimental liver injury in mice and rats

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胆宁片对实验性急慢性肝损伤的保护作用

1. 第二军医大学药学院天然药物化学教研室,上海200433; 2. 上海和黄药业有限公司研发部,上海200331; 3. 第二军医大学药学院药理学教研室,上海200433

English Abstract

The protective effects of Danning tablet on experimental liver injury in mice and rats

1. Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, China; 2. Shanghai Hehuang Pharmaceutical Company Limited, Shanghai 200331,China; 3. Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China

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目录

1. 第二军医大学药学院天然药物化学教研室,上海200433;

2. 上海和黄药业有限公司研发部,上海200331;

3. 第二军医大学药学院药理学教研室,上海200433