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Volume 29 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(2): 125-127

YOU Ben-ming, SONG Hong-jie. Investigation on stability of procaine hydrochloride injection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 125-127.
Citation: YOU Ben-ming, SONG Hong-jie. Investigation on stability of procaine hydrochloride injection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 125-127.
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Investigation on stability of procaine hydrochloride injection

  • Department of Pharmacy, Changhai Hospital ,Second Military Medical University, Shanghai 200433, China

  • Received Date: 2010-07-22
  • Rev Recd Date: 2010-12-15
  • Objective To investigate the effect of temperature and humidity on the stability of procaine hydrochloride injection. Methods Three batches of the test samples were stored in condition of 40±2 centigrade, relative humidity 75%±5% for 0 month,2 months, 4 months and 6 months respectively. Contents of procaine hydrochloride and its degradation product p-amino benzoic acid were determined in procaine hydrochloride injection by RP-HPLC. Results The content of procaine hydrochloride injection gradually decreased by 10% in 6 months, degradation products p-amino benzoic acid gradually increased by 412.89% in 6 months. Conclusion Procaine hydrochloride injection was instability in 40±2 centigrade and 75%±5% relative humidity condition.
  • [1] 叶 卿,宋洪杰,石力夫. 用RP-HPLC法测定心肌保护液中盐酸普鲁卡因及其降解产物对氨基苯甲酸的含量[J]. 药学服务与研究, 2009,9(1):40.
    [2] 祝清兰,李方实.普鲁卡因分析方法的研究进展[J]. 华西药学杂志,2004 ,19(1) :51.
    [3] 彭贤东,唐志立. 盐酸普鲁卡因注射液的稳定性考察[J]. 现代医药卫生,2005,21(12):1500.
    [4] 中国药典2010 年版.二部[S] .2010:794.
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Investigation on stability of procaine hydrochloride injection

  • Department of Pharmacy, Changhai Hospital ,Second Military Medical University, Shanghai 200433, China
  • Received Date: 2010-07-22
  • Rev Recd Date: 2010-12-15

Abstract: Objective To investigate the effect of temperature and humidity on the stability of procaine hydrochloride injection. Methods Three batches of the test samples were stored in condition of 40±2 centigrade, relative humidity 75%±5% for 0 month,2 months, 4 months and 6 months respectively. Contents of procaine hydrochloride and its degradation product p-amino benzoic acid were determined in procaine hydrochloride injection by RP-HPLC. Results The content of procaine hydrochloride injection gradually decreased by 10% in 6 months, degradation products p-amino benzoic acid gradually increased by 412.89% in 6 months. Conclusion Procaine hydrochloride injection was instability in 40±2 centigrade and 75%±5% relative humidity condition.

YOU Ben-ming, SONG Hong-jie. Investigation on stability of procaine hydrochloride injection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 125-127.
Citation: YOU Ben-ming, SONG Hong-jie. Investigation on stability of procaine hydrochloride injection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 125-127.
shu

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