Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 27 Issue 4
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(4): 279-281

WANG Jing, WANG Xiao-li, OU Yi-yi, GUO Jun-sheng. Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 279-281.
Citation: WANG Jing, WANG Xiao-li, OU Yi-yi, GUO Jun-sheng. Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 279-281.
shu

Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion

  • Department of Military Hygiene, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2008-11-19
  • Objective :To investigate the physico-chemical properties of scopolamine hydrobromide micromulsion and its transdermal delivery effect in vitro. Methods : The O/W microemulsion was prepared with the system contained of Cremophor RH-40-ethanol-Labrafil-water according to the pseudo-ternary phase diagrams.The values of droplet diameter and viscosity were investigated and the permeation flux of scopolamine hydrobromide was determined in vitro using Franz difusion cel1 with nude rats skin.The content of scopolamine hydrobromide was determined by HPLC. Results :The results indicated that the values of droplet diameter and viscosity and the permeation rate were influenced by the Km value and the contents of oil and water. Conclusion : The highest percutaneous scopolamine hydrobromide absorption microemulsion system with suitable diameter and viscosity contains 30%Cremophor RH-40+ethanol、10%Labrafil M 1944 CS 、1.5% scopolamine hydrobromide and 58.5% water,Km=21.
  • 加载中
通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2420) PDF downloads(777) Cited by()

Related
Proportional views

Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion

  • Department of Military Hygiene, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2008-11-19

Abstract: Objective :To investigate the physico-chemical properties of scopolamine hydrobromide micromulsion and its transdermal delivery effect in vitro. Methods : The O/W microemulsion was prepared with the system contained of Cremophor RH-40-ethanol-Labrafil-water according to the pseudo-ternary phase diagrams.The values of droplet diameter and viscosity were investigated and the permeation flux of scopolamine hydrobromide was determined in vitro using Franz difusion cel1 with nude rats skin.The content of scopolamine hydrobromide was determined by HPLC. Results :The results indicated that the values of droplet diameter and viscosity and the permeation rate were influenced by the Km value and the contents of oil and water. Conclusion : The highest percutaneous scopolamine hydrobromide absorption microemulsion system with suitable diameter and viscosity contains 30%Cremophor RH-40+ethanol、10%Labrafil M 1944 CS 、1.5% scopolamine hydrobromide and 58.5% water,Km=21.

WANG Jing, WANG Xiao-li, OU Yi-yi, GUO Jun-sheng. Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 279-281.
Citation: WANG Jing, WANG Xiao-li, OU Yi-yi, GUO Jun-sheng. Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 279-281.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: [email protected]

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return