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Volume 27 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(4): 261-263

YUAN Yi, WANG Jia-chun, WANG Zheng, CHU Zhi-yong, WANG Xu-hui, SHEN Yue, ZHANG Shu, LUAN Jie. Study on mechanism of action of Zhixiao Tongmaining granules on diabetic nephropathy[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 261-263.
Citation: YUAN Yi, WANG Jia-chun, WANG Zheng, CHU Zhi-yong, WANG Xu-hui, SHEN Yue, ZHANG Shu, LUAN Jie. Study on mechanism of action of Zhixiao Tongmaining granules on diabetic nephropathy[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 261-263.
shu

Study on mechanism of action of Zhixiao Tongmaining granules on diabetic nephropathy

  • 1.

    Department of Pharmacy, Central Hospital of Putuo District, Shanghai, 200062, China

  • 2.

    Naval Medical Research Institute of PLA, Shanghai 200433, China

  • 3.

    Qingfengge Pharmaceutical Science and Technology Co.Ltd, Shanghai 200092, China

  • Received Date: 2008-12-03
  • Objective :To investigate the effects of Zhixiao Tongmaining granules on diabetic nephropathy. Methods : The blood stasis of rats were detected by blood rheometer to investigate the effects of activating blood circulation to dissipate blood stasis of Zhixiao Tongmaining granules.The yin deficiency model of mice were made by intragastric administration of thyroxin(3 mg) and reserpine(0.01 mg/10 g) for investigating the effects of body weight of rats and endurance test.Mice qi-deficiency model of were made by limiting mice food-intake for one week for investigating the effects of body weight of rats and lymphocyte percentage of peripheral blood. Results :Compared with model group,Zhixiao Tongmaining granules can improve condition of blood stasis on rats,extend survival time of mice on staying power experiment,increase body weight of rats,index number of thymus,index number of spleen. Conclusion :Zhixiao Tongmaining granules can decrease whole blood specific viscosity of blood stasis rats,effectively improve condition of blood stasis.Zhixiao Tongmaining granules have the effect of improving the condition of yin deficency mice,also have part of therapeutic action on mice with qi deficiency.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Study on mechanism of action of Zhixiao Tongmaining granules on diabetic nephropathy

  • 1. Department of Pharmacy, Central Hospital of Putuo District, Shanghai, 200062, China
  • 2. Naval Medical Research Institute of PLA, Shanghai 200433, China
  • 3. Qingfengge Pharmaceutical Science and Technology Co.Ltd, Shanghai 200092, China
  • Received Date: 2008-12-03

Abstract: Objective :To investigate the effects of Zhixiao Tongmaining granules on diabetic nephropathy. Methods : The blood stasis of rats were detected by blood rheometer to investigate the effects of activating blood circulation to dissipate blood stasis of Zhixiao Tongmaining granules.The yin deficiency model of mice were made by intragastric administration of thyroxin(3 mg) and reserpine(0.01 mg/10 g) for investigating the effects of body weight of rats and endurance test.Mice qi-deficiency model of were made by limiting mice food-intake for one week for investigating the effects of body weight of rats and lymphocyte percentage of peripheral blood. Results :Compared with model group,Zhixiao Tongmaining granules can improve condition of blood stasis on rats,extend survival time of mice on staying power experiment,increase body weight of rats,index number of thymus,index number of spleen. Conclusion :Zhixiao Tongmaining granules can decrease whole blood specific viscosity of blood stasis rats,effectively improve condition of blood stasis.Zhixiao Tongmaining granules have the effect of improving the condition of yin deficency mice,also have part of therapeutic action on mice with qi deficiency.

YUAN Yi, WANG Jia-chun, WANG Zheng, CHU Zhi-yong, WANG Xu-hui, SHEN Yue, ZHANG Shu, LUAN Jie. Study on mechanism of action of Zhixiao Tongmaining granules on diabetic nephropathy[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 261-263.
Citation: YUAN Yi, WANG Jia-chun, WANG Zheng, CHU Zhi-yong, WANG Xu-hui, SHEN Yue, ZHANG Shu, LUAN Jie. Study on mechanism of action of Zhixiao Tongmaining granules on diabetic nephropathy[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 261-263.
shu

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