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Volume 24 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (5): 281-283

LIU Wei-Dong. Studies on the preparation and dissolution of sodium ferulate dropping pill[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 281-283.
Citation: LIU Wei-Dong. Studies on the preparation and dissolution of sodium ferulate dropping pill[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 281-283.
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Studies on the preparation and dissolution of sodium ferulate dropping pill

  • Department of Pharmacy, Linyi People's Hospital, Linyi 276005, China

  • Received Date: 2006-02-24
  • Objective: To improve the dissolution rate of sodium ferulate by preparing the dropping pill using the technology of solid dispersion. Methods: The dropping pill was prepared with PEG 6000 and poloxamer 188 as carriers.The dissolution rate of sodium fer-ulate was measured using the basket method as well as HPLC. Results: The higher the ratio of PEG 6000 vs sodium ferulate in the dropping pill was, the greater the dissolution rate of the drug was.The dropping pill prepared was rounded and homogeneous.With 0.1 mol/L hydrochloride solution, water and pH 6.8 phosphrate buffer solution as the media, the dissolution rate of sodium ferulate from dropping pill was significantly faster than that from the marketing tablet of sodium ferulate, respectively. Conclusion: Sodium ferulate dropping pill had excellent rapid release effect.
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Studies on the preparation and dissolution of sodium ferulate dropping pill

  • Department of Pharmacy, Linyi People's Hospital, Linyi 276005, China
  • Received Date: 2006-02-24

Abstract: Objective: To improve the dissolution rate of sodium ferulate by preparing the dropping pill using the technology of solid dispersion. Methods: The dropping pill was prepared with PEG 6000 and poloxamer 188 as carriers.The dissolution rate of sodium fer-ulate was measured using the basket method as well as HPLC. Results: The higher the ratio of PEG 6000 vs sodium ferulate in the dropping pill was, the greater the dissolution rate of the drug was.The dropping pill prepared was rounded and homogeneous.With 0.1 mol/L hydrochloride solution, water and pH 6.8 phosphrate buffer solution as the media, the dissolution rate of sodium ferulate from dropping pill was significantly faster than that from the marketing tablet of sodium ferulate, respectively. Conclusion: Sodium ferulate dropping pill had excellent rapid release effect.

LIU Wei-Dong. Studies on the preparation and dissolution of sodium ferulate dropping pill[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 281-283.
Citation: LIU Wei-Dong. Studies on the preparation and dissolution of sodium ferulate dropping pill[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 281-283.
shu

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