Improvement of determination of norfloxacin capsules by HPLC

Li Ming

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Volume 20 Issue 2

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2002 > (2): 97-99

Li Ming. Improvement of determination of norfloxacin capsules by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 97-99.

Citation:

Li Ming. Improvement of determination of norfloxacin capsules by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 97-99.

Improvement of determination of norfloxacin capsules by HPLC

Li Ming

Beihai Institute for Drug Control, Beihai 536000, China

Received Date: 2001-09-28

Abstract

OBJECTIVE Norfloxacin capsules was determined by a improved HPLC method. METHODS The separation was performed on a spherisorb C¹⁸ column.The mobile phase was composed of phosphoric acid-triethylamin buf fer-water-acet onitrile(60:30:10).The eluate with a flow rate of 1.0ml·min^-1 was detected at the wavelength of 278nm.RESULTS The calibration curves were good linear within the range of 4.8～96μg·ml^-1(r=0.99998).The average recovery of norfloxacin was 98.5%,with RSD of 0.5%(n=5).CONCLUSION The improved method is rapid,good repeatabitity,accurate,reliable and suitable for determination of norfloxacin capsules.
- Norfloxacin capsules,
- HPLC,
- determination of content
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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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