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Volume 17 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 1999  >  (4): 202-204

Wei Hongchang, Zhu Dongsheng, Zhu Xiaomei, Sun Pinglong, Dai Weiwei. Effects of preconditioning by yixin oral liquid on CEC,plasma ET & CGRP,myocardial pathomorphology of acute myocardial ischemia in rats[J]. Journal of Pharmaceutical Practice and Service, 1999, (4): 202-204.
Citation: Wei Hongchang, Zhu Dongsheng, Zhu Xiaomei, Sun Pinglong, Dai Weiwei. Effects of preconditioning by yixin oral liquid on CEC,plasma ET & CGRP,myocardial pathomorphology of acute myocardial ischemia in rats[J]. Journal of Pharmaceutical Practice and Service, 1999, (4): 202-204.
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Effects of preconditioning by yixin oral liquid on CEC,plasma ET & CGRP,myocardial pathomorphology of acute myocardial ischemia in rats

  • 1.

    Shanghai University of Traditional Chinese Medicine and Pharmacology, Shanghai 200032

  • 2.

  • 3.

  • Received Date: 1999-01-25
  • OBJECTIVE To investigate the protective effects of preconditioning by yixin oral liquid (YOL) on cardiovascular system of acute myocardial ischemia rats.METHODS Acute myocardial ischemia models in control group,verapamil group and YOL were set up,meanwhile the sham group was built up.Blood would be collected for assaying endothelin (ET) and calcitonin gene-related peptide (CGRP) in plasma,circle endothelial cell (CEG),and myocardial pathomorphological examination would be preceded after the myocardial ischemia models being set up for two hours.RESULTS Both YOL and verapamil could decrease not only the levels of plasma ET (P<0.05) and the amounts of CEC (P<0 01,P<0.05 respectively),but also ameliorate myocardial pathomorphological changes in acute myocardial ischemia rate.The contents of phasma CGRP in verapamil group were lower than those in model group (P<0.05).Difference of the up-mentioned three indexes between YOL group and verapamil group appeared to be insignificant.CONCLUSION Preconditioning by YOL might play an imporatant role in the modulation of plasma ET and CGRP as well as in the amelioration of myocardium and vascular endothelial cells in acute myocardial inchemia rats.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effects of preconditioning by yixin oral liquid on CEC,plasma ET & CGRP,myocardial pathomorphology of acute myocardial ischemia in rats

  • 1. Shanghai University of Traditional Chinese Medicine and Pharmacology, Shanghai 200032
  • 2. 
  • 3. 
  • Received Date: 1999-01-25

Abstract: OBJECTIVE To investigate the protective effects of preconditioning by yixin oral liquid (YOL) on cardiovascular system of acute myocardial ischemia rats.METHODS Acute myocardial ischemia models in control group,verapamil group and YOL were set up,meanwhile the sham group was built up.Blood would be collected for assaying endothelin (ET) and calcitonin gene-related peptide (CGRP) in plasma,circle endothelial cell (CEG),and myocardial pathomorphological examination would be preceded after the myocardial ischemia models being set up for two hours.RESULTS Both YOL and verapamil could decrease not only the levels of plasma ET (P<0.05) and the amounts of CEC (P<0 01,P<0.05 respectively),but also ameliorate myocardial pathomorphological changes in acute myocardial ischemia rate.The contents of phasma CGRP in verapamil group were lower than those in model group (P<0.05).Difference of the up-mentioned three indexes between YOL group and verapamil group appeared to be insignificant.CONCLUSION Preconditioning by YOL might play an imporatant role in the modulation of plasma ET and CGRP as well as in the amelioration of myocardium and vascular endothelial cells in acute myocardial inchemia rats.

Wei Hongchang, Zhu Dongsheng, Zhu Xiaomei, Sun Pinglong, Dai Weiwei. Effects of preconditioning by yixin oral liquid on CEC,plasma ET & CGRP,myocardial pathomorphology of acute myocardial ischemia in rats[J]. Journal of Pharmaceutical Practice and Service, 1999, (4): 202-204.
Citation: Wei Hongchang, Zhu Dongsheng, Zhu Xiaomei, Sun Pinglong, Dai Weiwei. Effects of preconditioning by yixin oral liquid on CEC,plasma ET & CGRP,myocardial pathomorphology of acute myocardial ischemia in rats[J]. Journal of Pharmaceutical Practice and Service, 1999, (4): 202-204.
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