QIN Cuiying, LI Rongli, LI Yunjing, CHEN Rencai, HAN Jing. Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 411-414,432. doi: 10.3969/j.issn.1006-0111.2017.05.006
| Citation:
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QIN Cuiying, LI Rongli, LI Yunjing, CHEN Rencai, HAN Jing. Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 411-414,432. doi: 10.3969/j.issn.1006-0111.2017.05.006
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Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology
- Received Date: 2016-11-25
- Rev Recd Date:
2017-04-25
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Abstract
Objective To prepare Herba Cistanche enteric release microspheres, optimize the preparation process and study the releasing characteristics of microspheres in vitro. Methods Ion gelatin-oven drying method was used to prepare Herba Cistanche enteric microspheres. The preparation process was optimized with the aid of a Box-Behnken design. Results The optimal preparation condition was 36.33 mg/ml of sodium alginate, 10.82 mg/ml of calcium chloride and 10.93 mg/ml of chitosan. Conclusion This technology is repeatable and feasible. The microspheres have high entrapment efficiency and good sustained release characteristics.
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