Anti-alcoholism effects of Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture on acute alcoholism mice

WANG Jie; ZHOU Rong; PAN Xiaowei; LU Yiming; TAO Hong

doi:10.3969/j.issn.1006-0111.2017.05.003

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Objective To study the anti-alcoholism effect of Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture on acute alcohol poisoning in mice. Methods A model of acute alcoholism in mice was established by intragastrical administration of alcohol. The best ratio of each component in the mixture was identified by observing the sobering effect of the mixtures on mice. The best ratio mixture was divided into low dose group and high dose group. The mice tolerance time, drunken time, the ethanol concentration in the blood and the alcohol dehydrogenase activity in liver were measured to study the anti-alcoholism effect of the mixture. Results The Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture not only increased the tolerance time and decreased the drunken time of mice, but also significantly reduced the ethanol concentration in blood and improved the activity of alcohol dehydrogenase in liver. Conclusion This study found that Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture has anti-alcoholism effect on acute alcoholism in mice.

Anti-alcoholism effects of Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture on acute alcoholism mice

1. Department of Biochemistry Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. Guangdong China Tobacco Industry Co., Ltd., Guangzhou 510385, China

Received Date: 2017-06-19

Rev Recd Date: 2017-08-24

Key words:

Abstract: Objective To study the anti-alcoholism effect of Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture on acute alcohol poisoning in mice. Methods A model of acute alcoholism in mice was established by intragastrical administration of alcohol. The best ratio of each component in the mixture was identified by observing the sobering effect of the mixtures on mice. The best ratio mixture was divided into low dose group and high dose group. The mice tolerance time, drunken time, the ethanol concentration in the blood and the alcohol dehydrogenase activity in liver were measured to study the anti-alcoholism effect of the mixture. Results The Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture not only increased the tolerance time and decreased the drunken time of mice, but also significantly reduced the ethanol concentration in blood and improved the activity of alcohol dehydrogenase in liver. Conclusion This study found that Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture has anti-alcoholism effect on acute alcoholism in mice.

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Anti-alcoholism effects of Puerariae lobatae radix, Puerariae lobatae flowers, Hovenia dulcis thunb mixture on acute alcoholism mice

doi: 10.3969/j.issn.1006-0111.2017.05.003

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