Preparation of paeoniflorin gastric floating tablets

JIA Jiali; HUANG Yueying; BIAN Jun

doi:10.3969/j.issn.1006-0111.2016.02.014

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Objective To prepare paeoniflorin gastric floating tablets and to optimize the formulation. Methods Gastric floating tablets were prepared by wet granulation, with floating performance and in vitro cumulative release rate as evaluat indicators, single factor tests and orthogonal design test were adopted for the optimal formulation. Results With HPMC K4M 20% as reinforcing materials, NaHCO₃ 15% as gas agent, PVPP 7% as the release of accelerator, lactose as a filler, the obtained gastric floating tablet can immediately play bleaching, continued to float more than 12 hours, and the cumulative release rate was more than 90%. Conclusion The optimal formulation of paeconiflorin floating tablet has achieved a sustained and slow release request floating, the operability is good.

Preparation of paeoniflorin gastric floating tablets

1. Department of Pharmacy, No.411 Hospital of PLA, Shanghai 200434, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

2. Department of Pharmacy, No.411 Hospital of PLA, Shanghai 200434, China

Received Date: 2015-02-08

Rev Recd Date: 2015-12-02

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Abstract: Objective To prepare paeoniflorin gastric floating tablets and to optimize the formulation. Methods Gastric floating tablets were prepared by wet granulation, with floating performance and in vitro cumulative release rate as evaluat indicators, single factor tests and orthogonal design test were adopted for the optimal formulation. Results With HPMC K4M 20% as reinforcing materials, NaHCO₃ 15% as gas agent, PVPP 7% as the release of accelerator, lactose as a filler, the obtained gastric floating tablet can immediately play bleaching, continued to float more than 12 hours, and the cumulative release rate was more than 90%. Conclusion The optimal formulation of paeconiflorin floating tablet has achieved a sustained and slow release request floating, the operability is good.

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Reference (7)

[1]	张玲玲,魏伟,汪庆童,等. 芍药苷对胶原性关节炎大鼠滑膜细胞G蛋白偶联信号的调节作用[J].中国药理学通报,2008,24(3):330-335.
[2]	陈尹,魏伟,吴虹,等.芍药苷对佐剂性关节炎大鼠脾细胞产生抗体和cAMP水平的影响[J].药学学报,2007,42(11):1147-1151.
[3]	陈广斌,陈华萍,吴铁,等. 芍药苷对缺氧缺血性脑损伤新生大鼠脑组织丙二醛、超氧化物歧化酶的影响[J].实用儿科临床杂志,2008,23(16):1272-1273.
[4]	Hung YJ,Yang CJ,Tsai MY,et al.Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligand-mediated apoptotic pathway in human non-small cell lung cancer A549 cells[J]. Clin Exp Pharmacol Physiol,2008,35(2):141-147.
[5]	杨琪伟,杨莉,熊爱珍,等.赤芍与白芍抗血小板凝集作用的UPLC-MS代谢组学初步研究[J]. 中国中药杂志,2011,36(6):698-701.
[6]	杨星钢,张立波,潘卫三,等.芍药苷大鼠在体肠吸收动力学的研究[J].中国药学杂志,2006,41(11):854-857.
[7]	金利泰.天然药物提取分离工艺学[M].杭州:浙江大学出版社,2011:10.

[1]	张玲玲,魏伟,汪庆童,等. 芍药苷对胶原性关节炎大鼠滑膜细胞G蛋白偶联信号的调节作用[J].中国药理学通报,2008,24(3):330-335.
[2]	陈尹,魏伟,吴虹,等.芍药苷对佐剂性关节炎大鼠脾细胞产生抗体和cAMP水平的影响[J].药学学报,2007,42(11):1147-1151.
[3]	陈广斌,陈华萍,吴铁,等. 芍药苷对缺氧缺血性脑损伤新生大鼠脑组织丙二醛、超氧化物歧化酶的影响[J].实用儿科临床杂志,2008,23(16):1272-1273.
[4]	Hung YJ,Yang CJ,Tsai MY,et al.Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligand-mediated apoptotic pathway in human non-small cell lung cancer A549 cells[J]. Clin Exp Pharmacol Physiol,2008,35(2):141-147.
[5]	杨琪伟,杨莉,熊爱珍,等.赤芍与白芍抗血小板凝集作用的UPLC-MS代谢组学初步研究[J]. 中国中药杂志,2011,36(6):698-701.
[6]	杨星钢,张立波,潘卫三,等.芍药苷大鼠在体肠吸收动力学的研究[J].中国药学杂志,2006,41(11):854-857.
[7]	金利泰.天然药物提取分离工艺学[M].杭州:浙江大学出版社,2011:10.

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Preparation of paeoniflorin gastric floating tablets

doi: 10.3969/j.issn.1006-0111.2016.02.014

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通讯作者: 陈斌, [email protected]

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