Study on the hypolipidemic effects of polydatin

GAO Yue; JI Qian

doi:10.3969/j.issn.1006-0111.2013.04.011

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Objective To investigate the hypolipidemic effects of polydatin on hyperlipidemic animals. Methods The models of hyperlipidemic rabbits and rats were established. Model animals were orally given polydatin for continuous 7 or 14 days and the serum levels of TC, TG, HDL and LDL were evaluated. Results Polydatin significantly decreased the serum levels of TC, TG, and LDL in hyperlipidemic rabbits, and markedly depressed the serum TG level in hyperlipidemic rats. Conclusions Polydatin possessed a favorable hypolipidemic activity.

Study on the hypolipidemic effects of polydatin

Department of pharmacognosy, School of pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2012-07-03

Rev Recd Date: 2012-11-28

Key words:

polydatin /
blood lipid /
rabbit /
rat

Abstract: Objective To investigate the hypolipidemic effects of polydatin on hyperlipidemic animals. Methods The models of hyperlipidemic rabbits and rats were established. Model animals were orally given polydatin for continuous 7 or 14 days and the serum levels of TC, TG, HDL and LDL were evaluated. Results Polydatin significantly decreased the serum levels of TC, TG, and LDL in hyperlipidemic rabbits, and markedly depressed the serum TG level in hyperlipidemic rats. Conclusions Polydatin possessed a favorable hypolipidemic activity.

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Reference (7)

[1]	Pan YM, Zhang XP, Wang HS, et al. Antioxidant potential of ethanolic extract of Polygonum cuspidatum and application in peanut oil[J]. Food Chem, 2007, 105(4):1518.
[2]	Cheng YF, Zhang HT, Sun LS, et al. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury[J]. Brain Res, 2006, 1110(1):193.
[3]	Jordan KC, Freeland-Graves JH, Klohe-Lehman DM, et al. A nutrition and physical activity intervention promotes weight loss and enhances diet attitudes in low-income mothers of young children[J]. Nutr Res, 2008, 28(1):13.
[4]	Huang ZS, Wang ZW, Liu MP, et al. Protective effects of polydatin against CCl(4)-induced injury to primarily cultured rat hepatocytes[J]. World J Gastroenterol, 1999;5(1):41.
[5]	李锋,王贤波. 茶叶中EGC对高脂大鼠的降血脂作用[J]. 浙江农业科学,2012(1):32.
[6]	魏碧娜,黄铭珊,邓元荣,等. 油茶皂苷对高脂血症大鼠血脂的影响[J]. 海峡药学,2011,23(12):38.
[7]	刘雪梅,吴符火. 几类高脂血症动物模型的比较[J]. 中西医结合学报,2004,4(4):132.

[1]	Pan YM, Zhang XP, Wang HS, et al. Antioxidant potential of ethanolic extract of Polygonum cuspidatum and application in peanut oil[J]. Food Chem, 2007, 105(4):1518.
[2]	Cheng YF, Zhang HT, Sun LS, et al. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury[J]. Brain Res, 2006, 1110(1):193.
[3]	Jordan KC, Freeland-Graves JH, Klohe-Lehman DM, et al. A nutrition and physical activity intervention promotes weight loss and enhances diet attitudes in low-income mothers of young children[J]. Nutr Res, 2008, 28(1):13.
[4]	Huang ZS, Wang ZW, Liu MP, et al. Protective effects of polydatin against CCl(4)-induced injury to primarily cultured rat hepatocytes[J]. World J Gastroenterol, 1999;5(1):41.
[5]	李锋,王贤波. 茶叶中EGC对高脂大鼠的降血脂作用[J]. 浙江农业科学,2012(1):32.
[6]	魏碧娜,黄铭珊,邓元荣,等. 油茶皂苷对高脂血症大鼠血脂的影响[J]. 海峡药学,2011,23(12):38.
[7]	刘雪梅,吴符火. 几类高脂血症动物模型的比较[J]. 中西医结合学报,2004,4(4):132.

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Study on the hypolipidemic effects of polydatin

doi: 10.3969/j.issn.1006-0111.2013.04.011

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通讯作者: 陈斌, [email protected]

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