Effect of combined therapy with piperazine ferulate and benazepdl on urinary albumin excretion rate in patients with early diabetic nephropathy

TU Chuan-fa; WANG Li-jun; JIN Du; YANG Hong-wei; ZHANG You-you; MOU Xiao-yue

doi:10.3969/j.issn.1006-0111.2013.01.014

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To explore the effect of combined therapy with piperazine ferulate and benazepdl on urinary albumin excretion rate (UAER) in patients with early diabetic nephropathy (DN). Methods A total of 164 children were included in the study, 82 of whom accepted piperazine ferulate and benazepdl were put into the observed group, 82 of whom accepted only benazepdl were put into the control group. The difference of the UAER, 24 h urinary protein, Serum creatinine, blood glucose, glycosylated hemoglobin and CRP were compared by T test. Results ①After treatment, the UAER, 24 h urinary protein, CRP and blood pressure were significantly lower than that before treatment in both observed group and control group;②The UAER, 24 h urinary protein and CRP were significantly lower in the observed group than that of the control group after treatment. Conclusion Combined use of piperazine ferulate and benazepdl could significantly lower the levels of UAER in patients with early DN.

Effect of combined therapy with piperazine ferulate and benazepdl on urinary albumin excretion rate in patients with early diabetic nephropathy

Endocrine Department, the First People Hospital of Taizhou, Taizhou 318020, China

Received Date: 2012-03-08

Rev Recd Date: 2012-07-07

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Abstract: To explore the effect of combined therapy with piperazine ferulate and benazepdl on urinary albumin excretion rate (UAER) in patients with early diabetic nephropathy (DN). Methods A total of 164 children were included in the study, 82 of whom accepted piperazine ferulate and benazepdl were put into the observed group, 82 of whom accepted only benazepdl were put into the control group. The difference of the UAER, 24 h urinary protein, Serum creatinine, blood glucose, glycosylated hemoglobin and CRP were compared by T test. Results ①After treatment, the UAER, 24 h urinary protein, CRP and blood pressure were significantly lower than that before treatment in both observed group and control group;②The UAER, 24 h urinary protein and CRP were significantly lower in the observed group than that of the control group after treatment. Conclusion Combined use of piperazine ferulate and benazepdl could significantly lower the levels of UAER in patients with early DN.

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Reference (6)

[1]	Song J, Li YH, Yang XD. Effect of combined therapy with bailing capsule and benazepril on urinary albumin excretion rate and C-reactive protein in patients with early diabetic nephropathy[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2009, 29(9): 791.
[2]	World Health Organization.Definition,diagnosis and classification of diabetes mellitus[J]. Report of a WHO consulation. Geneva: World Health Organization, 1999: 442.
[3]	Ito H, Komatsu Y, Mifune M, et al. The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study[J]. Cardiovasc Diabetol, 2010, 15(1): 9.
[4]	康辉, 张秀丽, 柴红宇. 保肾康治疗早期糖尿病肾病的临床观察[J]. 中国民康医学, 2009, 21(3): 252.
[5]	赵艳平. 胰激肽原酶联合保肾康治疗糖尿病肾病疗效观察[J]. 中外医疗, 2011, 15(1): 148.
[6]	何关富. 金水宝与保肾康治疗糖尿病肾病的比较研究[J]. 中国现代药物应用, 2010, 4(6): 130.

[1]	Song J, Li YH, Yang XD. Effect of combined therapy with bailing capsule and benazepril on urinary albumin excretion rate and C-reactive protein in patients with early diabetic nephropathy[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2009, 29(9): 791.
[2]	World Health Organization.Definition,diagnosis and classification of diabetes mellitus[J]. Report of a WHO consulation. Geneva: World Health Organization, 1999: 442.
[3]	Ito H, Komatsu Y, Mifune M, et al. The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study[J]. Cardiovasc Diabetol, 2010, 15(1): 9.
[4]	康辉, 张秀丽, 柴红宇. 保肾康治疗早期糖尿病肾病的临床观察[J]. 中国民康医学, 2009, 21(3): 252.
[5]	赵艳平. 胰激肽原酶联合保肾康治疗糖尿病肾病疗效观察[J]. 中外医疗, 2011, 15(1): 148.
[6]	何关富. 金水宝与保肾康治疗糖尿病肾病的比较研究[J]. 中国现代药物应用, 2010, 4(6): 130.

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Effect of combined therapy with piperazine ferulate and benazepdl on urinary albumin excretion rate in patients with early diabetic nephropathy

doi: 10.3969/j.issn.1006-0111.2013.01.014

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通讯作者: 陈斌, [email protected]

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