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帕唑帕尼的临床应用和药品不良反应的研究进展

周陈建,  赵嫏嬛,  胡国新

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周陈建, 赵嫏嬛, 胡国新. 帕唑帕尼的临床应用和药品不良反应的研究进展[J]. 药学实践与服务, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
引用本文: 周陈建, 赵嫏嬛, 胡国新. 帕唑帕尼的临床应用和药品不良反应的研究进展[J]. 药学实践与服务, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
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ZHOU Chenjian, ZHAO Langhuan, HU Guoxin. Progress of pazopanib in clinical applications and adverse drug reaction[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
Citation: ZHOU Chenjian, ZHAO Langhuan, HU Guoxin. Progress of pazopanib in clinical applications and adverse drug reaction[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
shu

帕唑帕尼的临床应用和药品不良反应的研究进展

doi: 10.3969/j.issn.1006-0111.2016.06.005
  • 1.

    温州市中心医院, 浙江 温州 325000

  • 2.

    温州市人民医院, 浙江 温州 325000

  • 3.

    温州市医科大学, 浙江 温州 325000

Progress of pazopanib in clinical applications and adverse drug reaction

  • 1.

    Wenzhou Central Hospital, Wenzhou 325000, China

  • 2.

    People's Hospital of Wenzhou, Wenzhou 325000, China

  • 3.

    Wenzhou Medical University, Wenzhou 325000, China

  • 摘要: 帕唑帕尼是一种多靶点酪氨酸激酶抑制剂，研究发现帕唑帕尼主要用于治疗肾细胞癌、卵巢癌、乳腺癌和肺癌等疾病，并可能导致腹泻、高血压、头发褪色、恶心和厌食等不良反应。
    Abstract: Pazopanib is a multi-targeted tyrosine kinase inhibitor, and is mainly used to treat renal cell carcinoma, ovarian cancer, breast cancer, and lung cancer. The researchers also found that pazopanib may cause diarrhea, hypertension, hair loss, nausea, and anorexia. This paper reviewed pazopanib clinical application and adverse reactions, and provided a basis for this medication.
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    [18] Pili R, QIN R, Flynn PJ, et al.A phase Ⅱ safety and efficacy study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor pazopanib in patients with metastatic urothelial cancer[J]. Clin Genitourin Cancer,2013,11(4):477-483.
    [19] Gril B, Palmieri D, QIAN Y, et al. Pazopanib reveals a role for tumor cell BRaf in the prevention of HER2+ breast cancer brain metastasis[J]. Clin Cancer Res,2010, 17(1):142-153.
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    [21] Podar K,Tonon G,Sattler M, et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma[J]. Proc Natl Acad Sci (USA), 2006, 103(51):19478-19483.
    [22] Grossniklaus HE, Ling JX,Wallace TM, et al.
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  • 收稿日期:  2015-12-22
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帕唑帕尼的临床应用和药品不良反应的研究进展

doi: 10.3969/j.issn.1006-0111.2016.06.005
  • 1. 温州市中心医院, 浙江 温州 325000
  • 2. 温州市人民医院, 浙江 温州 325000
  • 3. 温州市医科大学, 浙江 温州 325000
  • 收稿日期: 2015-12-22
  • 修回日期: 2016-05-16

摘要: 帕唑帕尼是一种多靶点酪氨酸激酶抑制剂，研究发现帕唑帕尼主要用于治疗肾细胞癌、卵巢癌、乳腺癌和肺癌等疾病，并可能导致腹泻、高血压、头发褪色、恶心和厌食等不良反应。

English Abstract

周陈建, 赵嫏嬛, 胡国新. 帕唑帕尼的临床应用和药品不良反应的研究进展[J]. 药学实践与服务, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
引用本文: 周陈建, 赵嫏嬛, 胡国新. 帕唑帕尼的临床应用和药品不良反应的研究进展[J]. 药学实践与服务, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
shu
ZHOU Chenjian, ZHAO Langhuan, HU Guoxin. Progress of pazopanib in clinical applications and adverse drug reaction[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
Citation: ZHOU Chenjian, ZHAO Langhuan, HU Guoxin. Progress of pazopanib in clinical applications and adverse drug reaction[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 497-500. doi: 10.3969/j.issn.1006-0111.2016.06.005
shu

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