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1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习

秦又发,  张庆,  刘莉

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文章导航 > 药学实践与服务  > 2016 >  34(2): 181-183
秦又发, 张庆, 刘莉. 1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习[J]. 药学实践与服务, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022
引用本文: 秦又发, 张庆, 刘莉. 1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习[J]. 药学实践与服务, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022
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QIN Youfa, ZHANG Qing, LIU Li. Clinical analysis of 1 case of micafungin treatment: fluconazole-exposed candidemia and review of related literature[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022
Citation: QIN Youfa, ZHANG Qing, LIU Li. Clinical analysis of 1 case of micafungin treatment: fluconazole-exposed candidemia and review of related literature[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022
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1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习

doi: 10.3969/j.issn.1006-0111.2016.02.022
  • 1.

    东莞市第三人民医院药学部, 广东 东莞 523326

  • 2.

    南方医科大学附属南方医院药学部, 广州 510515

  • 3.

    湖北医药学院附属随州医院药学部, 湖北 随州 441300

Clinical analysis of 1 case of micafungin treatment: fluconazole-exposed candidemia and review of related literature

  • 1.

    Department of Pharmacy, Third people's Hospital of Dongguan, Dongguan 523326, China

  • 2.

    Department of Pharmacy, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou 510515, China

  • 3.

    Department of Pharmacy, Suizhou Hospital of Hubei Medicine College, Suizhou 441300, China

  • 摘要: 目的 探讨临床药师参与有氟康唑暴露史念珠菌血症患者治疗的对策及效果,为临床有效控制此类感染提供参考。 方法 在伏立康唑治疗该病患者效果不佳的情况下,临床药师建议采用米卡芬净抗念珠菌治疗。 结果 患者的念珠菌感染得到有效控制。 结论 米卡芬净能有效治疗近期(<30 d)有氟康唑暴露史的念珠菌血行感染。临床药师参与临床治疗实践,协助制订个体化治疗方案,有利于提高临床药物治疗水平。
    Abstract: Objective To investigate countermeasures and effects of clinical pharmacists participating in the treatment for fluconazole-exposure candidemia, and to provide reference for infectious control in the clinic. Methods Clinical pharmacists used their professional knowledge and suggested utilizing micafungin to treat candidemia, when voriconazole was ineffective in a patient with candidemia and fluconazole exposure history. Results The patient's candida bloodstream infection was finally controlled. Clinical pharmacists were highly complimented from the doctors, nurses and patients. Conclusion Micafungin is effective in treatment of candidemia with a recent(<30 days) fluconazole exposure history. The participation of clinical pharmacists is helpful to develop individual medicinal therapy in clinical treatment and can improve therapeutic effects.
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    [2] Anunnatsiri S, Chetchotisakd P, Mootsikapun P.Fungemia in non-HIV-infected patients:a five-year review.[J].Int J Infect Dis, 2009, 13(1):90-96.
    [3] Playford EG, Lipman J, Sorrell TC.Management of invasive candidiasis in the intensive care unit.[J].Drugs, 2010, 70(7):823-839.
    [4] Pappas PG, Kauffman CA, Andes D,et al.Clinical practice guidelines for the management of candidiasis:2009 update by the Infectious Diseases Society of America.[J].Clin Infect Dis, 2009, 48(5):503-535.
    [5] Ostrosky-Zeichner L, Pappas PG.Invasive candidiasis in the intensive care unit[J].Crit Care Med, 2006, 34(3):857-863.
    [6] Sanford JP. 热病:桑福德抗微生物治疗指南[M].北京:中国协和医科大学出版社,2011:73.
    [7] Prasad PA, Fisher BT, Coffin SE,et al.Pediatric risk factors for candidemia secondary to and species[J].J Pediatric Infect Dis Soc, 2013, 2(3):263-266.
    [8] Shah DN, Yau R, Lasco TM,et al.Impact of prior inappropriate fluconazole dosing on isolation of fluconazole-nonsusceptible Candida species in hospitalized patients with candidemia[J].Antimicrob Agents Chemother, 2012, 56(6):3239-3243.
    [9] Borst A, Raimer MT, Warnock DW,et al.Rapid acquisition of stable azole resistance by candida glabrata isolates obtained before the clinical introduction of fluconazole[J].Antimicrob Agents Chemother, 2005, 49(2):783-787.
    [10] Lortholary O, Desnos-Ollivier M, Sitbon K,et al.Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia:a prospective multicenter study involving 2,441 patients[J].Antimicrob Agents Chemother, 2011, 55(2):532-538.
    [11] Magill SS, Shields C, Sears CL,et al.Triazole cross-resistance among Candida spp.:case report, occurrence among bloodstream isolates, and implications for antifungal therapy[J].J Clin Microbiol, 2006, 44(2):529-535.
    [12] Chang TP, Ho MW, Yang YL,et al.Distribution and drug susceptibilities of Candida species causing candidemia from a medical center in central Taiwan[J].J Infect Chemother, 2013.
    [13] Pfaller MA, Diekema DJ, Ostrosky-Zeichner L,et al.Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin, and micafungin:analysis and proposal for interpretive MIC breakpoints[J].J Clin Microbiol, 2008, 46(8):2620-2629.
    [14] Messer SA, Diekema DJ, Boyken L,et al.Activities of micafungin against 315 invasive clinical isolates of fluconazole-resistant Candida spp.[J].J Clin Microbiol, 2006, 44(2):324-326.
    [15] 胡晶,商洪才,李晶,等.血必净注射液治疗脓毒症的系统评价[J].解放军医学杂志,2010(1):9-12.
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  • 收稿日期:  2014-08-02
  • 修回日期:  2015-08-28

1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习

doi: 10.3969/j.issn.1006-0111.2016.02.022
  • 1. 东莞市第三人民医院药学部, 广东 东莞 523326
  • 2. 南方医科大学附属南方医院药学部, 广州 510515
  • 3. 湖北医药学院附属随州医院药学部, 湖北 随州 441300
  • 收稿日期: 2014-08-02
  • 修回日期: 2015-08-28

摘要: 目的 探讨临床药师参与有氟康唑暴露史念珠菌血症患者治疗的对策及效果,为临床有效控制此类感染提供参考。 方法 在伏立康唑治疗该病患者效果不佳的情况下,临床药师建议采用米卡芬净抗念珠菌治疗。 结果 患者的念珠菌感染得到有效控制。 结论 米卡芬净能有效治疗近期(<30 d)有氟康唑暴露史的念珠菌血行感染。临床药师参与临床治疗实践,协助制订个体化治疗方案,有利于提高临床药物治疗水平。

English Abstract

秦又发, 张庆, 刘莉. 1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习[J]. 药学实践与服务, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022
引用本文: 秦又发, 张庆, 刘莉. 1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习[J]. 药学实践与服务, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022
shu
QIN Youfa, ZHANG Qing, LIU Li. Clinical analysis of 1 case of micafungin treatment: fluconazole-exposed candidemia and review of related literature[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022
Citation: QIN Youfa, ZHANG Qing, LIU Li. Clinical analysis of 1 case of micafungin treatment: fluconazole-exposed candidemia and review of related literature[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022
shu

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