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氟康唑类似物的研究进展

许克寒,  黄蕾,  吴俊琪,  戚麟,  金永生,  俞世冲

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文章导航 > 药学实践与服务  > 2016 >  34(2): 110-113,128
许克寒, 黄蕾, 吴俊琪, 戚麟, 金永生, 俞世冲. 氟康唑类似物的研究进展[J]. 药学实践与服务, 2016, 34(2): 110-113,128. doi: 10.3969/j.issn.1006-0111.2016.02.004
引用本文: 许克寒, 黄蕾, 吴俊琪, 戚麟, 金永生, 俞世冲. 氟康唑类似物的研究进展[J]. 药学实践与服务, 2016, 34(2): 110-113,128. doi: 10.3969/j.issn.1006-0111.2016.02.004
shu
XU Kehan, HUANG Lei, WU Junqi, QI Lin, JIN Yongsheng, YU Shichong. Research progress of fluconazole derivatives[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 110-113,128. doi: 10.3969/j.issn.1006-0111.2016.02.004
Citation: XU Kehan, HUANG Lei, WU Junqi, QI Lin, JIN Yongsheng, YU Shichong. Research progress of fluconazole derivatives[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 110-113,128. doi: 10.3969/j.issn.1006-0111.2016.02.004
shu

氟康唑类似物的研究进展

doi: 10.3969/j.issn.1006-0111.2016.02.004

  • 第二军医大学药学院有机化学教研室, 上海 200433

基金项目: 第二军医大学药学院药学实验中心孵化基地重点课题;本科学员创新实践能力孵化基地项目(2015YJ06)

Research progress of fluconazole derivatives

  • Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 氟康唑是第三代三唑类抗真菌药物,具有水溶性好、广谱和低毒等优点,是临床上治疗真菌感染的首选药物。随着氟康唑耐药菌株的不断出现,研制新型氟康唑类似物成为重要的科研课题。通过对氟康唑结构的修饰,获得新型氟康唑类似物,为进一步的新药合成研究提供线索。
    Abstract: Fluconazole, the third generation of triazole-antifungal drug, becomes the first choice in the treatment of fungal infection due to its broad antifungal spectrum, good water solubility and low toxicity. With an increasingly drug-resistant strain, developing new fluconazole derivatives is becoming an attractive topic. This review mainly indicates that people can get new fluconazole derivatives used by clinic through structural modification of fluconazole, which will give clues for advanced research.
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    [9] Wang WY, Sheng CQ, Che XY, et al. Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives[J]. Arch Pharm(Weinheim), 2009, 342(12):732-739.
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    [13] Chai XY, Zhang J, Yu SC, et al. Design,synthesis,and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols[J]. Bioorg Med Chem Lett, 2009, 19(6):1811-1814.
    [14] Giraud F, Loge C, Pagniez F, et al. Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phn-yl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents[J]. Bioorg Med Chem Lett, 2008, 18(6):1820-1824.
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出版历程
  • 收稿日期:  2015-01-04
  • 修回日期:  2015-04-24

氟康唑类似物的研究进展

doi: 10.3969/j.issn.1006-0111.2016.02.004
  • 第二军医大学药学院有机化学教研室, 上海 200433
    • 基金项目:  第二军医大学药学院药学实验中心孵化基地重点课题;本科学员创新实践能力孵化基地项目(2015YJ06)
  • 收稿日期: 2015-01-04
  • 修回日期: 2015-04-24

摘要: 氟康唑是第三代三唑类抗真菌药物,具有水溶性好、广谱和低毒等优点,是临床上治疗真菌感染的首选药物。随着氟康唑耐药菌株的不断出现,研制新型氟康唑类似物成为重要的科研课题。通过对氟康唑结构的修饰,获得新型氟康唑类似物,为进一步的新药合成研究提供线索。

English Abstract

许克寒, 黄蕾, 吴俊琪, 戚麟, 金永生, 俞世冲. 氟康唑类似物的研究进展[J]. 药学实践与服务, 2016, 34(2): 110-113,128. doi: 10.3969/j.issn.1006-0111.2016.02.004
引用本文: 许克寒, 黄蕾, 吴俊琪, 戚麟, 金永生, 俞世冲. 氟康唑类似物的研究进展[J]. 药学实践与服务, 2016, 34(2): 110-113,128. doi: 10.3969/j.issn.1006-0111.2016.02.004
shu
XU Kehan, HUANG Lei, WU Junqi, QI Lin, JIN Yongsheng, YU Shichong. Research progress of fluconazole derivatives[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 110-113,128. doi: 10.3969/j.issn.1006-0111.2016.02.004
Citation: XU Kehan, HUANG Lei, WU Junqi, QI Lin, JIN Yongsheng, YU Shichong. Research progress of fluconazole derivatives[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 110-113,128. doi: 10.3969/j.issn.1006-0111.2016.02.004
shu

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