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替吉奥治疗晚期乳腺癌的研究进展

郑婷 钱其军

郑婷, 钱其军. 替吉奥治疗晚期乳腺癌的研究进展[J]. 药学实践与服务, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
引用本文: 郑婷, 钱其军. 替吉奥治疗晚期乳腺癌的研究进展[J]. 药学实践与服务, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
ZHENG Ting, QIAN Qijun. Progress on S-1 in the treatment of advanced breast cancer[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
Citation: ZHENG Ting, QIAN Qijun. Progress on S-1 in the treatment of advanced breast cancer[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021

替吉奥治疗晚期乳腺癌的研究进展

doi: 10.3969/j.issn.1006-0111.2015.06.021
基金项目: 国家科技重大专项(No.2013ZX10002-010-007)

Progress on S-1 in the treatment of advanced breast cancer

  • 摘要: 替吉奥(S-1)是第三代氟尿嘧啶衍生物的口服抗癌剂,毒副作用小、疗效确切、给药方便。在大量的临床试验及不断的临床应用中,其展示出对晚期乳腺癌(advanced breast cancer,ABC)治疗的良好效果,将来有望成为乳腺癌治疗的一线化疗药物。
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    [15] Yamamoto D,Iwase S,Yoshida H,et al.Efficacy of S-1 in patients with capecitabine-resistantbreast cancer-Japan Breast Cancer Research Network (JBCRN) 04-1 trial[J].Anticancer Res,2010,30(9): 3827-3831.
    [16] Mukai H, Takashima T, HozumiY,et al.Randomized study of taxane versus TS-1 in women with metastatic or recurrent breast cancer (SELECT BC) [J].Jpn J Clin Oncol, 2010,40(8):811-814.
    [17] Nohara T,Iwamoto M,Sumiyoshi K, et al.Examination of the clinical usefulness of TS-1 in locally recurrent breast cancer[J]. Oncol Let,2010,1(4): 669-672.
    [18] Yamamoto Y, Nishimura R, Tanigawa T,et al.Efficacy and safety of TS-1 monotherapy for advanced/metastatic breast cancer-an observational study by the Kumamoto Breast Cancer Cooperative Group(KBCCG)].GanTo Kagaku Ryoho. 2014,41(10):1221-1225.
    [19] Kobayashi Y, Kadoya T, Kanno E,et al.A resected case of complete response after treatment with S-1 for recurrent squamous cell carcinoma component of the breast[J].GanTo Kagaku Ryoho,2012,39(9):1403-1406.
    [20] Tazawa K, Tsuchiya Y, Shinbo M,et al.Effective chemotherapy with S-1 alone in a patient with lung metastases of breast cancer[J].GanTo Kagaku Ryoho, 2011,38(3):423-425.
    [21] Yoshida H, Yamamoto D, Kanematsu S,et al.A case of multi-drug resistant breast cancer with liver metastasis treated effectively by S-1 monotherapy[J].GanTo Kagaku Ryoho,2010,37(13):2901-2903.
    [22] Takeyama H, Kyoda S, Yamashita A,et al.A case of repeated bone metastases of breast carcinoma successfully treated by S-1 chemotherapy[J].GanTo Kagaku Ryoho,2011,38(11):1873-1875.
    [23] Mori T, Yoshimura G, Ito D,et al.Three cases effectively treated with S-1 therapy for liver metastasis of breast cancer in long term[J].GanTo Kagaku Ryoho,2011,38(9):1495-1498.
    [24] Kubo H, Kijima D, Tada K,et al.A case of anthracycline- and taxane-resistant recurrent advanced breast cancer successfully treated with S-1 monotherapy[J].GanTo Kagaku Ryoho,2010,37(7):1325-1327.
    [25] Kato M, Kitayama J, Yamaguchi H,et al.Three cases of metastatic breast cancer effectively treated with S-1 therapy[J].GanTo Kagaku Ryoho,2010,37(5):903-906.
    [26] Aoyagi H, Kaneko J, Makinose T,et al.A case of stage IV breast cancer responding to S-1 therapy after FEC and PTX therapies[J].GanTo Kagaku Ryoho,2009,36(12):2474-2476.
    [27] Takashima T, Nakayama T, Yoshidome K,et al.Phase Ⅱ study of s-1 in combination with trastuzumab for HER2-positive metastatic breast cancer[J].Anticancer Res, 201434: 3583-3588 .
    [28] Ishida K.A case of recurrent breast cancer with liver metastases showing good response to combination therapy with S-1plus trastuzumab[J].GanTo Kagaku Ryoho,2013,40(10):1385-1387.
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  • 收稿日期:  2015-02-09
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替吉奥治疗晚期乳腺癌的研究进展

doi: 10.3969/j.issn.1006-0111.2015.06.021
    基金项目:  国家科技重大专项(No.2013ZX10002-010-007)

摘要: 替吉奥(S-1)是第三代氟尿嘧啶衍生物的口服抗癌剂,毒副作用小、疗效确切、给药方便。在大量的临床试验及不断的临床应用中,其展示出对晚期乳腺癌(advanced breast cancer,ABC)治疗的良好效果,将来有望成为乳腺癌治疗的一线化疗药物。

English Abstract

郑婷, 钱其军. 替吉奥治疗晚期乳腺癌的研究进展[J]. 药学实践与服务, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
引用本文: 郑婷, 钱其军. 替吉奥治疗晚期乳腺癌的研究进展[J]. 药学实践与服务, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
ZHENG Ting, QIAN Qijun. Progress on S-1 in the treatment of advanced breast cancer[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
Citation: ZHENG Ting, QIAN Qijun. Progress on S-1 in the treatment of advanced breast cancer[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
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