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二氢黄酮类化合物的合成研究进展

梁海,  向卓,  张学辉,  吴久鸿

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文章导航 > 药学实践与服务  > 2015 >  33(2): 97-101,130
梁海, 向卓, 张学辉, 吴久鸿. 二氢黄酮类化合物的合成研究进展[J]. 药学实践与服务, 2015, 33(2): 97-101,130. doi: 10.3969/j.issn.1006-0111.2015.02.001
引用本文: 梁海, 向卓, 张学辉, 吴久鸿. 二氢黄酮类化合物的合成研究进展[J]. 药学实践与服务, 2015, 33(2): 97-101,130. doi: 10.3969/j.issn.1006-0111.2015.02.001
shu
LIANG Hai, XIANG Zhuo, ZHANG Xuehui, WU Jiuhong. Reviews on flavanone compounds synthesis research[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 97-101,130. doi: 10.3969/j.issn.1006-0111.2015.02.001
Citation: LIANG Hai, XIANG Zhuo, ZHANG Xuehui, WU Jiuhong. Reviews on flavanone compounds synthesis research[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 97-101,130. doi: 10.3969/j.issn.1006-0111.2015.02.001
shu

二氢黄酮类化合物的合成研究进展

doi: 10.3969/j.issn.1006-0111.2015.02.001
  • 1.

    安徽医科大学药学院, 安徽 合肥 230032;解放军306医院药学部, 北京 100101

  • 2.

    解放军306医院药学部, 北京 100101

基金项目: 国家自然科学基金项目(No.81072546)

Reviews on flavanone compounds synthesis research

  • 1.

    School of Pharmacy, Anhui Medical University, Hefei 230032, China;Department of Pharmacy, No.306 Hospital of PLA, Beijing 100101, China

  • 2.

    Department of Pharmacy, No.306 Hospital of PLA, Beijing 100101, China

  • 摘要: 综述二氢黄酮类化合物的合成研究进展, 总结已报道的各种类型的二氢黄酮合成方法, 为二氢黄酮类新药研发提供方法学支持。合成方法包括:查尔酮环合、Friedel-Crafts反应、Knoevenagel缩合和Hoesch单酰基化反应, 以及二氢黄酮的不对称合成, 并简要介绍无溶剂合成二氢黄酮等"绿色"化学方法。
    Abstract: Research progress of flavanone compounds synthesis was reviewed, various types of synthesis methods of flavanone compounds were summarized, and methodological support for flavanone compounds in new drug research and development was provided. Research progress in synthesis of flavanone compounds includes chalcone cyclization, Friedel-Crafts reaction, Knoevenagel condensation, Hoesch single acetoxylation, and asymmetric synthesis of flavanone compounds. Solvent-free synthesis of flavanone compounds and other green chemistry methods were also introduced.
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  • 收稿日期:  2013-11-28
  • 修回日期:  2014-04-21

二氢黄酮类化合物的合成研究进展

doi: 10.3969/j.issn.1006-0111.2015.02.001
  • 1. 安徽医科大学药学院, 安徽 合肥 230032;解放军306医院药学部, 北京 100101
  • 2. 解放军306医院药学部, 北京 100101
    • 基金项目:  国家自然科学基金项目(No.81072546)
  • 收稿日期: 2013-11-28
  • 修回日期: 2014-04-21

摘要: 综述二氢黄酮类化合物的合成研究进展, 总结已报道的各种类型的二氢黄酮合成方法, 为二氢黄酮类新药研发提供方法学支持。合成方法包括:查尔酮环合、Friedel-Crafts反应、Knoevenagel缩合和Hoesch单酰基化反应, 以及二氢黄酮的不对称合成, 并简要介绍无溶剂合成二氢黄酮等"绿色"化学方法。

English Abstract

梁海, 向卓, 张学辉, 吴久鸿. 二氢黄酮类化合物的合成研究进展[J]. 药学实践与服务, 2015, 33(2): 97-101,130. doi: 10.3969/j.issn.1006-0111.2015.02.001
引用本文: 梁海, 向卓, 张学辉, 吴久鸿. 二氢黄酮类化合物的合成研究进展[J]. 药学实践与服务, 2015, 33(2): 97-101,130. doi: 10.3969/j.issn.1006-0111.2015.02.001
shu
LIANG Hai, XIANG Zhuo, ZHANG Xuehui, WU Jiuhong. Reviews on flavanone compounds synthesis research[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 97-101,130. doi: 10.3969/j.issn.1006-0111.2015.02.001
Citation: LIANG Hai, XIANG Zhuo, ZHANG Xuehui, WU Jiuhong. Reviews on flavanone compounds synthesis research[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 97-101,130. doi: 10.3969/j.issn.1006-0111.2015.02.001
shu

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