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降脂药物的肝脏毒性及其防治策略研究进展

徐岩成,  方一杰,  阎澜,  姜远英,  曹永兵

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文章导航 > 药学实践与服务  > 2014 >  32(6): 412-415,464
徐岩成, 方一杰, 阎澜, 姜远英, 曹永兵. 降脂药物的肝脏毒性及其防治策略研究进展[J]. 药学实践与服务, 2014, 32(6): 412-415,464. doi: 10.3969/j.issn.1006-0111.2014.06.004
引用本文: 徐岩成, 方一杰, 阎澜, 姜远英, 曹永兵. 降脂药物的肝脏毒性及其防治策略研究进展[J]. 药学实践与服务, 2014, 32(6): 412-415,464. doi: 10.3969/j.issn.1006-0111.2014.06.004
shu
XU Yancheng, FANG Yijie, YAN Lan, JIANG Yuanying, CAO Yongbing. Progress on the hepatotoxicity of lipid-lowering drugs and its prevention strategies[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 412-415,464. doi: 10.3969/j.issn.1006-0111.2014.06.004
Citation: XU Yancheng, FANG Yijie, YAN Lan, JIANG Yuanying, CAO Yongbing. Progress on the hepatotoxicity of lipid-lowering drugs and its prevention strategies[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 412-415,464. doi: 10.3969/j.issn.1006-0111.2014.06.004
shu

降脂药物的肝脏毒性及其防治策略研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.004
  • 1.

    福建中医药大学药学院, 福建 福州 350108;第二军医大学药学院, 上海 200433

  • 2.

    第二军医大学药学院, 上海 200433;沈阳药科大学生命科学与生物制药学院, 辽宁 沈阳 110016

  • 3.

    第二军医大学药学院, 上海 200433

Progress on the hepatotoxicity of lipid-lowering drugs and its prevention strategies

  • 1.

    School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China;School of Life Science and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang 110016, China

  • 3.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 肝脏毒性是降血脂药物治疗常见的毒副作用之一,其发生机制尚不完全清楚,大多数降血脂药物的毒副作用都是剂量依赖性的,而且在停药后都有明显的缓解与改善。高龄以及慢性疾病等都是诱发降血脂药物肝脏毒性的潜在因素。降血脂药物的肝脏损伤治疗暂无统一规范,临床应对策略以停药、非特异性保肝和对症治疗为主。研发低毒性或具有保肝作用的降血脂药物,尤其是中药及中药制剂是一个具有良好前景的发展方向。
    Abstract: Hepatotoxicity is one of the most common adverse reactions during anti-hyperlipidemia treatment. Mechanisms of anti-hyperlipidemia drug-induced hepatotoxicity are not clear yet, but most of the toxic reactions are dose-related hypersensitivity and could be released after drug withdrawal. It is accepted that clinical risk factors for the development of hepatotoxicity during anti-hyperlipidemia treatment are high age and chronic illnesses. Treatment of anti-hyperlipidemia drug-induced hepatotoxicity has not been unified and most of the treatments are non-specific and symptomatic. Researching hypotoxicity and hepatoprotection antihyperlipidemia drug, especially TCM and pharmaceutics will become a promising direction.
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  • 收稿日期:  2013-10-29
  • 修回日期:  2014-06-11

降脂药物的肝脏毒性及其防治策略研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.004
  • 1. 福建中医药大学药学院, 福建 福州 350108;第二军医大学药学院, 上海 200433
  • 2. 第二军医大学药学院, 上海 200433;沈阳药科大学生命科学与生物制药学院, 辽宁 沈阳 110016
  • 3. 第二军医大学药学院, 上海 200433
  • 收稿日期: 2013-10-29
  • 修回日期: 2014-06-11

摘要: 肝脏毒性是降血脂药物治疗常见的毒副作用之一,其发生机制尚不完全清楚,大多数降血脂药物的毒副作用都是剂量依赖性的,而且在停药后都有明显的缓解与改善。高龄以及慢性疾病等都是诱发降血脂药物肝脏毒性的潜在因素。降血脂药物的肝脏损伤治疗暂无统一规范,临床应对策略以停药、非特异性保肝和对症治疗为主。研发低毒性或具有保肝作用的降血脂药物,尤其是中药及中药制剂是一个具有良好前景的发展方向。

English Abstract

徐岩成, 方一杰, 阎澜, 姜远英, 曹永兵. 降脂药物的肝脏毒性及其防治策略研究进展[J]. 药学实践与服务, 2014, 32(6): 412-415,464. doi: 10.3969/j.issn.1006-0111.2014.06.004
引用本文: 徐岩成, 方一杰, 阎澜, 姜远英, 曹永兵. 降脂药物的肝脏毒性及其防治策略研究进展[J]. 药学实践与服务, 2014, 32(6): 412-415,464. doi: 10.3969/j.issn.1006-0111.2014.06.004
shu
XU Yancheng, FANG Yijie, YAN Lan, JIANG Yuanying, CAO Yongbing. Progress on the hepatotoxicity of lipid-lowering drugs and its prevention strategies[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 412-415,464. doi: 10.3969/j.issn.1006-0111.2014.06.004
Citation: XU Yancheng, FANG Yijie, YAN Lan, JIANG Yuanying, CAO Yongbing. Progress on the hepatotoxicity of lipid-lowering drugs and its prevention strategies[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 412-415,464. doi: 10.3969/j.issn.1006-0111.2014.06.004
shu

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