老年药物性肝损害的临床特点

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老年药物性肝损害的临床特点

唐险峰, 孙杰, 路明珠

文章导航 > 药学实践与服务 > 2013 > 31(1): 22-23,66

唐险峰, 孙杰, 路明珠. 老年药物性肝损害的临床特点[J]. 药学实践与服务, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006

引用本文:

唐险峰, 孙杰, 路明珠. 老年药物性肝损害的临床特点[J]. 药学实践与服务, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006

TANG Xian-feng, SUN Jie, LU Ming-zhu. The clinical features of drug-induced liver injury in elderly[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006

Citation:

TANG Xian-feng, SUN Jie, LU Ming-zhu. The clinical features of drug-induced liver injury in elderly[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006

老年药物性肝损害的临床特点

doi: 10.3969/j.issn.1006-0111.2013.01.006

1.
总后上海干休所, 上海 200437
2.
第二军医大学附属长征医院药剂科, 上海 200003

The clinical features of drug-induced liver injury in elderly

1.
Shanghai Retired Cadres, General Logistics Department, Shanghai, 200437 China
2.
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

摘要: 药物引起的肝毒性是老年人肝脏疾病的重要原因,发生率是年轻人的4倍多,且类型几乎包括了所有已知的肝脏疾病。因为大多数的临床试验排除了大于75~80岁年龄组患者,有关药物副作用的报告在大于60岁年龄组中相当罕见。为此,需要进一步的临床研究,以探讨老年患者肝脏的药物副作用。本文主要综述了老年药物性肝损害的主要临床表现和诊断以及近年来常见药物(心血管药物和抗微生物药物)引起肝损伤的临床情况。
- 老年人 /
- 不良反应 /
- 药物性肝损害
Abstract: Drug-induced hepato-toxicity was an important reason for the liver disease in elderly,which was four times more common than in adults and might include all known liver disorders. Reports related to drug side effects were rare in people >60 years of age group since most clinical trials exclude patients >75~80 years of age. Further clinical studies should be need to investigate hepatic side effects of drugs in elderly patients. The main clinical manifestations and diagnosis of drug-induced liver injury in elderly as well as common drugs (cardiovascular drugs and anti-microbial agents) cause liver injury in clinical conditions were reviewed in this paper.
- elderly /
- adverse event /
- drug-induced liver injury

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老年药物性肝损害的临床特点

doi: 10.3969/j.issn.1006-0111.2013.01.006

1. 总后上海干休所, 上海 200437

2. 第二军医大学附属长征医院药剂科, 上海 200003

收稿日期: 2012-04-25
修回日期: 2012-11-12

关键词:

药物性肝损害

摘要: 药物引起的肝毒性是老年人肝脏疾病的重要原因,发生率是年轻人的4倍多,且类型几乎包括了所有已知的肝脏疾病。因为大多数的临床试验排除了大于75~80岁年龄组患者,有关药物副作用的报告在大于60岁年龄组中相当罕见。为此,需要进一步的临床研究,以探讨老年患者肝脏的药物副作用。本文主要综述了老年药物性肝损害的主要临床表现和诊断以及近年来常见药物(心血管药物和抗微生物药物)引起肝损伤的临床情况。

English Abstract

唐险峰, 孙杰, 路明珠. 老年药物性肝损害的临床特点[J]. 药学实践与服务, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006

引用本文:

唐险峰, 孙杰, 路明珠. 老年药物性肝损害的临床特点[J]. 药学实践与服务, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006

TANG Xian-feng, SUN Jie, LU Ming-zhu. The clinical features of drug-induced liver injury in elderly[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006

Citation:

TANG Xian-feng, SUN Jie, LU Ming-zhu. The clinical features of drug-induced liver injury in elderly[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 22-23,66. doi: 10.3969/j.issn.1006-0111.2013.01.006

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