Optimization of extraction technology for Toufu irrigation by orthogonal test
-
摘要: 目的 优化透肤洗剂的提取工艺,提高透肤洗剂的质量。 方法 采用正交试验法,以加水量、提取时间、提取次数为考察因素,以苦参碱的含量为考察指标,优化提取工艺。 结果 最佳提取工艺的加水量是饮片量的8倍,提取2次,每次90 min。 结论 该工艺合理可行、稳定性好,可保证制剂质量。Abstract: Objective To optimize the extraction process and improve the quality of Toufu irrigation. Methods Matrine assay was selected to be the indicator for the extraction efficacy. Orthogonal test was used to determine the optimal water amount, extraction time and extraction frequency. Results The best extraction process was to extract 90 minutes twice with the water amount 8 times of the dry herbal material by weight. Conclusion This process is feasible and repeatable. It can be used for the quality control of the preparation.
-
Key words:
- Toufu irrigation /
- matrine /
- orthogonal test
-
[1] 杨霄,于喜水,金哲雄.苦参生物碱提取工艺研究进展[J].黑龙江医药,2013,26(3):425-427. [2] 王光函,张宏,姜鸿,等.基于苦参碱含量的中药失眠小复方提取工艺研究[J].时珍国医国药,2015;26(11):2673-2674. [3] 国家药典委员会.中华人民共和国药典2015年版(一部)[S].北京:化学工业出版社,2015:202-203. [4] 娄方璐,刁庆春,刘毅,等. 湿疹中医外治处方用药规律分析[J]. 陕西中医,2012,33(1):97-100. [5] 张翅,马悦,高慧敏,等. 苦参化学成分研究进展[J]. 中国实验方剂学杂志,2014,20(4):205-214. [6] 智信,陈晓,苏佳灿.苦参碱药理作用研究进展[J].成都中医药大学学报,2017;40(1):123-127. [7] 吴芳妮,张芊,张春雷. 苦参在T细胞介导的皮肤良恶性疾病中的应用进展[J].中国皮肤性病学杂志,2016,30(8):847-849. [8] 郭德祥,郭亚楠,李向阳. 苦参碱的提取纯化工艺研究[J]. 河南畜牧兽医(综合版),2013(3):12-14.
计量
- 文章访问数: 3331
- HTML全文浏览量: 407
- PDF下载量: 693
- 被引次数: 0