丹参素及其衍生物心血管作用机制的研究进展

焦育强; 刘文斌; 袁夏; 姜玉; 田霖; 金磊; 张川

doi:10.3969/j.issn.1006-0111.2015.05.002

丹参素及其衍生物心血管作用机制的研究进展

doi: 10.3969/j.issn.1006-0111.2015.05.002

焦育强¹,
刘文斌²,
袁夏²,
姜玉²,
田霖¹,
金磊²,
张川^2,

1.
福建中医药大学药学院, 福建福州 350108
2.
第二军医大学药学院, 上海 200433

Study progress of Danshensu and its derivatives in cardiovascular mechanism

1.
School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China
2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 丹参素是丹参的主要水溶性活性成分之一,具有多种药理活性,尤其对心血管系统具有明显的保护作用。笔者从抗凋亡、抗氧化、抑制钙超载和作用于炎症反应通路等方面,对丹参素及其衍生物心血管药理作用机制进行综述。
- 丹参素 /
- 丹参素衍生物 /
- 抗凋亡 /
- 抗氧化 /
- 钙超载 /
- 炎症反应
Abstract: Danshensu is one of the main water soluble active ingredients of Salvia miltiorrhiza, which has many pharmacological activities, especially in cardiovascular system. The cardiovascular pharmacological mechanism of Danshensu and its derivatives from the view of anti-apoptosis, antioxidant, inhibiting calcium overload and role in the inflammatory reaction pathways etc. were summarized in this article.
- Danshensu /
- derivatives /
- anti-apoptosis /
- antioxidant /
- calcium overload /
- inflammatory reaction

[1]	Wu L, Qiao H, Li Y, et al. Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats[J]. Phytomedicine, 2007, 14(10): 652-658.
[2]	Yin Y, Guan Y, Duan JL, et al. Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation[J].Eur J Pharmacol, 2013, 669(1): 219-226.
[3]	Lam FFY, Yeung JHK, Chan KM, et al. Relaxant effects of danshen aqueous extract and its constituent danshensu on rat oronary artery are mediated by inhibition of calcium channels[J].Vascul Pharmacol, 2007, 46(4): 271-277.
[4]	Tang YQ, Wang MH, Le XY, et al. Antioxidant and cardioprotective effects of Danshensu (3-(3,4-dih-ydroxyph-enyl)-2-hydroxy-propanoic acid from salvia miltiorrhiza) on isoproterenol-induced myocardial hypertrophy in rats[J].Phytomedicine, 2011, 18(12): 1024-1030.
[5]	Le XY, Chen CL, Ma L, et al. Effects of Danshensu on the incidence of ischemia-reperfusioninduced arrhythmia in hypertrophy rat heart[J].Chin J Nat Med, 2008, 6(6): 461-465.
[6]	Wang F, Liu YY, Liu LY, et al. The attenuation effect of 3,4-dihydroxy-phenyl lactic acid and salvianolic acid B on venular thrombosis induced in rat mesentery by photochemical reaction[J].Clin Hemorheol Microcirc, 2009, 42(1): 7-18.
[7]	Tang YQ, Wang MH, Chen CL, et al. Cardiovascular protection with Danshensu in spontaneously hypertensive rats[J].Biol Pharm Bull, 2011, 34(10): 1596-1601.
[8]	Yellon DM, Hausenloy DJ. Myocardial reperfusion injury[J].N Engl J Med, 2007, 357(11): 1121-1135.
[9]	Feuerstein GZ. Apoptosis-new opportunities for novel therapeutics for heart diseases[J].Cardiovasc Drugs Ther, 2001, 15(6): 547-551.
[10]	郭自强, 王硕仁, 朱陵群, 等. 丹参素和川芎嗪对血管紧张素Ⅱ诱导乳鼠心肌细胞凋亡的影响[J].中西医结合脑血管病杂志, 2006, 4(6): 494-495.
[11]	Liam P, Grant N, Caitlin C, et al. Anti-apoptosis and cell survival: a review[J].Biochim Biophys Acta, 2011, 1813(1): 238-259.
[12]	Jia YL, Dong XY, Zhou PF, et al. The synthesis and biological evaluation of novel Danshensu-ecysteine analog conjugates as cardiovascular-protective agents[J].Eur J Med Chem, 2012, 55: 176-187.
[13]	Zhao GR,Zhang HM,Ye TX,et al.Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B[J]. Food Chem Toxicol,2008,46(1):73-81.
[14]	陆文铨, 张国强, 陈大贵, 等. 丹参素对大鼠急性心肌缺血的保护作用[J].药学实践杂志, 2010, 28(4): 279-282.
[15]	王胜男, 叶攀, 敖杰男. 丹参素对过氧化氢所致人脐静脉内层细胞损伤的保护作用研究[J].时珍国医国药, 2011, 22(1): 66-69.
[16]	童海达, 王佳茗, 宋英. Keapl-Nrf2-ARE在机体氧化应激损伤中的防御作用[J].癌变畸变突变, 2013, 25(1): 71-75.
[17]	李冰. Nrf2信号通路及其分子调控机制[J].国外医学(医学地理分册), 2012, 33(3): 148-150.
[18]	Cui GZ, Shan LC, Hung MW, et al. A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways[J].Int J Cardiol, 2013,168(2):1349-1359.
[19]	顾明, 吴兴文, 李芳萍, 等. 丹参素对大鼠心室肌动作电位、L-型钙电流和ATP敏感性钾电流的作用[J].中国临床药学杂志, 2010, 19(1): 1-5.
[20]	钱为民, 邓春玉, 薛玉梅, 等. 丹参素对豚鼠心室肌细胞L-型钙通道的影响[J].岭南心血管病杂志, 2002, 8(4): 276-278.
[21]	赵艳威, 谢文利, 孙文军, 等. 丹参素对豚鼠心室肌细胞钠电流的影响[J].武警医学院学报, 2005, 14(4): 256-257.
[22]	张洁, 曾晓荣, 杨艳, 等. 丹参素对猪冠脉平滑肌细胞钙激活钾通道的作用[J].基础医学与临床, 2005, 25(11): 1054-1057.
[23]	董六一, 陈志武. 心肌缺血/再灌注损伤与炎症反应[J].中国临床药理学与治疗学, 2008, 13(5): 582-588.
[24]	Guan Y, Yin Y, Zhu YR, et al. Dissection of mechanisms of a Chinese medicinal formula Danhong injection therapy for myocardia ischemia reperfusion injury in vivo and in vitro[J].Evid Based Complement Alternat Med, 2013,2013(2):1-124.
[25]	权伟, 周丹, 郭超, 等. 丹参素钠通过抑制炎症反应对心肌缺血再灌注损伤的保护作用[J].中南药学, 2012, 12: 885-888.
[26]	姜开余, 顾振纶, 阮长耿. 丹参素对CD11b、P-selectin、ICAM-1、VCAM-1、E-selectin表达的影响[J].中国药理学通报, 2000, 16(6): 682-685.
[27]	Ridder DA, Schwaninger M. NF-κB signaling in cerebral ischemia[J].Neuroscience, 2009, 158(3): 995-1006.
[28]	Liu XH, Pan LL, Jia YL, et al. A novel compound DSC suppresses lipopolysaccharide-induced inflammatory responses by inhibition of Akt/NF-κB signallingn in macrophages[J].Eur J Pharmacol, 2013, 708(1): 8-13.
[29]	Xie XN, Wang SX, Xiao L, et al. DBZ blocks LPS-induced monocyte activation and foam cell formation via inhibiting nuclear factor-κB[J].Cell Physiol Biochem, 2011, 28(4): 649-662.
[30]	Yang GD, Zhang H, Lin R, et al. Down-regulation of CD40 gene expression and inhibition of apoptosis with Danshensu in endothelial cells[J].Basic Clin Pharmacol Toxicol, 2009, 104(2): 87-92.

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丹参素及其衍生物心血管作用机制的研究进展

doi: 10.3969/j.issn.1006-0111.2015.05.002

Study progress of Danshensu and its derivatives in cardiovascular mechanism

计量

丹参素及其衍生物心血管作用机制的研究进展

doi: 10.3969/j.issn.1006-0111.2015.05.002

1. 福建中医药大学药学院, 福建福州 350108

2. 第二军医大学药学院, 上海 200433

English Abstract

Study progress of Danshensu and its derivatives in cardiovascular mechanism

1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China

2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

全文HTML

目录

留言板

丹参素及其衍生物心血管作用机制的研究进展

doi: 10.3969/j.issn.1006-0111.2015.05.002

Study progress of Danshensu and its derivatives in cardiovascular mechanism

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出版历程

丹参素及其衍生物心血管作用机制的研究进展

doi: 10.3969/j.issn.1006-0111.2015.05.002

1. 福建中医药大学药学院, 福建 福州 350108 2. 第二军医大学药学院, 上海 200433

English Abstract

Study progress of Danshensu and its derivatives in cardiovascular mechanism

1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China 2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

全文HTML

目录

1. 福建中医药大学药学院, 福建福州 350108

2. 第二军医大学药学院, 上海 200433

1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China

2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China