异甘草酸镁预防奥沙利铂肝损伤的临床观察

吕建峰; 刘华; 叶爱琴; 刘君; 丁荣杰

doi:10.3969/j.issn.1006-0111.2015.02.021

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

异甘草酸镁预防奥沙利铂肝损伤的临床观察

吕建峰, 刘华, 叶爱琴, 刘君, 丁荣杰

文章导航 > 药学实践与服务 > 2015 > 33(2): 171-172

吕建峰, 刘华, 叶爱琴, 刘君, 丁荣杰. 异甘草酸镁预防奥沙利铂肝损伤的临床观察[J]. 药学实践与服务, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021

引用本文:

吕建峰, 刘华, 叶爱琴, 刘君, 丁荣杰. 异甘草酸镁预防奥沙利铂肝损伤的临床观察[J]. 药学实践与服务, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021

LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021

Citation:

LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021

异甘草酸镁预防奥沙利铂肝损伤的临床观察

doi: 10.3969/j.issn.1006-0111.2015.02.021

泰兴市人民医院, 江苏泰兴 225400

Observation of glutathione to prevent oxaliplatin-induced hepatic lesion

Taixing People's Hospital, Taixing 225400, China

摘要: 目的观察异甘草酸镁预防奥沙利铂致肝损伤的疗效。方法对照组采用奥沙利铂、亚叶酸钙、氟尿嘧啶方案化疗,治疗组采用奥沙利铂、亚叶酸钙、氟尿嘧啶方案化疗同时使用异甘草酸镁,以28 d为1个疗程,治疗周期为2~4个疗程,观察患者发生肝损伤的比例。结果对照组肝损伤发生率为44.4%,治疗组肝损伤发生率为19.4%,两组间有显著性差异(P<0.01)。结论异甘草酸镁可有效预防奥沙利铂所致的肝损伤,值得临床推广使用。
- 奥沙利铂 /
- 异甘草酸镁 /
- 肝损伤
Abstract: Objective To observe the curative effect of magnesium isoglycyrrhizinate in prevention of liver injury induced by oxaliplatin. Methods The control group used oxaliplatin, leucovorin, 5-fluorouracil chemotherapy, the treatment group were treated with oxaliplatin, leucovorin, 5-fluorouracil chemotherapy and simultaneous magnesium isoglycyrrhizinate were used at the same time. With 28 d for 1 course of treatment, the treatment period consisted of 2-4 courses, observation of patients and the proportion of liver injury were made. Results In the control group, liver injury incidence rate was 44.4%, the rate of injury was 19.4% in treatment group, there was significant difference between the two groups (P<0.01). Conclusion Magnesium isoglycyrrhizinate could be effective in prevention of oxaliplatin induced liver injury.
- oxalic acid platinum /
- magnesium isoglycyrrhizinate injection /
- liver function damage

[1]	叶爱琴,吕建峰,刘华.草酸铂致肝损伤的临床观察[J].肿瘤防治研究,2007,34(10):783-784.
[2]	孙燕,周际昌.临床肿瘤内科手册[M].4版.北京:人民卫生出版社,2004:102.
[3]	Slade JH, Alattar ML, Fogelman DR, et al. Portal hypertension associated with oxaliplatin administration: clinical manifestations of hepatic sinusoidal injury[J].Clin Colorectal Cancer,2009,8(4): 225-230.
[4]	Overman MJ, Maru DM, Charnsangavej C, et al. Oxaliplatin-mediated increase in spleen size as a biomarker for the development of hepatic sinusoidal injury[J].J Clin Oncol,2010,28(15): 2549-2555.
[5]	Motoori S, Kawase T, Nishimura H, et al. Two cases of advanced colorectal cancer which demonstrated the reversibility of oxaliplatin-mediated increase in splenic volume[J].Gan To Kagaku Ryoho,2011,38(4): 677-680.
[6]	陈玉强,洪节约,张雅雅,等.异甘草酸镁治疗肝癌动脉栓塞化疗肝损伤的临床研究[J].实用临床医药杂志,2010,14(17):15-17.
[7]	Mao YM,Zeng MD,Chen Y.Magnesium isoglycyrrhizinate in the treatment of chronic liver diseases:a randomized,doubleblind,multi-doses,active drug controlled,multi-center study[J].Zhonghua Gan Zang Bing Za Zhi,2009,17:847-851.
[8]	赵艳娟,杨梓梅.异甘草酸镁治疗慢性重型乙型肝炎的临床疗效观察[J].临床肝胆病杂志,2010,26(5):524-526.
[9]	董大勇.异甘草酸镁治疗慢性乙型肝炎的临床观察.实用临床医药杂志,2010,14(19):36-37.

[1]	刘丽艳, 余小翠, 孙传铎. 纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
[2]	徐璐璐, 刘爱军. 丹参白术方“异病同治”冠心病、血管性痴呆、特发性膜性肾病的网络药理学作用机制研究 . 药学实践与服务, 2024, 42(12): 1-8. doi: 10.12206/j.issn.2097-2024.202312027
[3]	唐淑慧, 凤美娟, 薛智霞, 鲁桂华. 帕博利珠单抗治疗所致免疫相关不良反应与中医体质的相关性研究 . 药学实践与服务, 2024, 42(5): 217-222. doi: 10.12206/j.issn.2097-2024.202311029
[4]	石晓萍, 吕迁洲, 李晓宇, 许青. 泊沙康唑对比伏立康唑经验治疗或诊断驱动治疗免疫功能低下患者侵袭性霉菌病的成本-效果分析 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202401050
[5]	杨嘉宁, 赵一颖, 肖伟. 七味脂肝方对非酒精性脂肪性肝炎动物模型的药效学评价 . 药学实践与服务, 2024, 42(9): 389-398. doi: 10.12206/j.issn.2097-2024.202404096
[6]	迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛. 负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034
[7]	修建平, 杨朝爱, 刘禧澳, 潘乾禹, 韦广旭, 王卫星. 全反式维甲酸对肝星状细胞活化及氧化应激的作用和机制探索 . 药学实践与服务, 2024, 42(7): 291-296. doi: 10.12206/j.issn.2097-2024.202312054
[8]	姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量. 巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 285-290, 296. doi: 10.12206/j.issn.2097-2024.202305011
[9]	李想, 陆鸿远, 张明玉, 高欢, 姚东, 许子华. 米格列醇激活UCP1介导棕色脂肪对冷暴露小鼠损伤的研究 . 药学实践与服务, 2024, 42(): 1-6. doi: 10.12206/j.issn.2097-2024.202404005
[10]	张晶晶, 索丽娜, 郑兆红. 89例细菌性肝脓肿的临床特征及抗感染治疗分析 . 药学实践与服务, 2024, 42(6): 267-272. doi: 10.12206/j.issn.2097-2024.202302039
[11]	宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅. 帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(8): 334-340. doi: 10.12206/j.issn.2097-2024.202303023
[12]	张岩, 李炎君, 刘家荟, 邓娇, 原苑, 张敬一. 药物性肝损伤不良反应分析 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404034

点击查看大图

计量

文章访问数: 3909
HTML全文浏览量: 311
PDF下载量: 455
被引次数: 0

异甘草酸镁预防奥沙利铂肝损伤的临床观察

doi: 10.3969/j.issn.1006-0111.2015.02.021

泰兴市人民医院, 江苏泰兴 225400

收稿日期: 2013-12-10
修回日期: 2014-03-17

关键词:

奥沙利铂 /

异甘草酸镁 /

肝损伤

摘要: 目的观察异甘草酸镁预防奥沙利铂致肝损伤的疗效。方法对照组采用奥沙利铂、亚叶酸钙、氟尿嘧啶方案化疗,治疗组采用奥沙利铂、亚叶酸钙、氟尿嘧啶方案化疗同时使用异甘草酸镁,以28 d为1个疗程,治疗周期为2~4个疗程,观察患者发生肝损伤的比例。结果对照组肝损伤发生率为44.4%,治疗组肝损伤发生率为19.4%,两组间有显著性差异(P<0.01)。结论异甘草酸镁可有效预防奥沙利铂所致的肝损伤,值得临床推广使用。