含β-丙氨酸的双链寡聚酰胺的合成
Synthesis of hairpin-polyamides containing β-alanine
-
摘要: 目的: 建立分子内含β-丙氨酸的双链寡聚酰胺的合成新方法和策略。 方法: 通过优化硝基氢化还原的方法,采用2+2片段偶合的策略,以1-羟基苯并三唑(HOBT)/N,N'-二环乙基碳酰亚胺(DCC)为缩合剂进行双链寡聚酰胺的合成。 结果: 高产率合成出了双链寡聚酰胺分子NO2ImPyβImPyγImPyβPyPyβCOOC2H5。 结论: 通过对反应温度、反应溶剂以及片段的选择优化,可以简便有效地合成分子内含有β-丙氨酸的双链寡聚酰胺。Abstract: Objective To develop a new method and strategy for the synthesis of hairpin-polyamides containingβ-alanine. Methods The hairpin-polyamides were synthesized by the HOBT/DCC coupling reaction in good yields through the optimization of hydrogenation of nitro group and the 2+2 fragment coupling strategy. Results A hairpin-polyamide NO2ImPyβImPyγImPyβPyPyβCOOC2H2 was synthesized successfully with good yield. Conclusion The hairpin-polyamides containing β-alanine in the molecular can be easily and efficiently synthesized through the optimization of reaction temperature,solvent and fragment coupling strategy.
-
Key words:
- β-alanine /
- polyamide /
- N-methyl Pyrrole /
- N-methyl imidazole,synthesis /
-
点击查看大图
计量
- 文章访问数: 3040
- HTML全文浏览量: 887
- PDF下载量: 390
- 被引次数: 0
下载:
