丹参素对麻醉犬血流动力学的影响
Influence of danshensu on hemodynamics of anesthetic dog
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摘要: 目的: 观察丹参素钠注射液静注给药对正常麻醉犬心率、血压、心脏收缩舒张功能等血流动力学指标的影响。 方法: 采用心脏导管法直接观察丹参素钠注射液(2、4、8 mg/kg)对麻醉犬心率(HR)、收缩压(SAP)、舒张压(DAP)、平均动脉压(MAP)、左心室收缩压(LVSP)、左心室平均压(MLVP)、左心室收缩压最大变化速率(±dp/dtmax)、左心室舒张末期压(LV-EDP)等血流动力学的影响。 结果: 丹参素钠注射液显著增加LVSP、±dp/dtmax,对SAP、DAP、MDP无显著影响;高剂量组显著降低心率。 结论: 丹参素钠注射液可显著改善心功能,具有减轻心脏负荷,降低心肌耗氧量的作用。Abstract: Objective To observe the influence of danshensu-sodium injection on the hemodynamics of anesthetic dog including heart rate,blood pressure,cardiac systolic/diastolic function. Methods The hemodynamics of dog after injected danshensu-sodium injection(2,4,8 mg/kg)were measured by cardiac catheter method respectively.Hemodynamics index such as heart rate(HR)、systolic arterial pressure(SAP)、diastolic arterial pressure(DAP)、mean arterial pressure(MAP)、left ventricular systolic pressure(LVSP)、mean left ventricular pressure(MLVP)、the maximal change rate of left intraventricular pressure(±dp/dtmax)、and left ventricular end diastolic pressure(LVEDP)was analysed. Results Danshensu-sodium injection can increase LVSP、±dp/dtmax remarkably,has no significant influence on SAP、DAP、MDP.And heart rate slows down obiviously in the high dosage group. Conclusion Danshensu-sodium injection can improve the cardiac function significantly through decreasing cardiac load and myocardial consumption of oxygen.
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Key words:
- danshensu-sodium injection /
- hemodynamics /
- dog
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