以牡蛎壳粉-CMC为载体制备阿司匹林胃漂浮片的研究
Preparation of aspirin intergastric floating tablet with carrier of oyster shell powder and sodium carboxymethyl cellulose
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摘要: 目的: 研制具有多微孔吸附特性的牡蛎壳粉和羧甲基纤维素钠(CMC)为复合药物载体的阿司匹林(ASP)胃漂浮片,并考察其体外释药特性和体外漂浮性能。 方法: 采用紫外分光光度法进行释放度试验。根据累积释药曲线对各组阿司匹林(ASP)胃漂浮片的释药过程分别进行数学模型拟合,从而研究片剂中的牡蛎壳粉与CMC的用量对释药过程的影响。 结果: 处方Ⅱ具有良好的漂浮性能,释药过程最理想,其释药过程符合体外释药特征零级动力学过程,其模拟方程为Q=0.0804T+0.1462,相关系数r=0.9987。 结论: 阿司匹林胃漂浮片达到设计要求。Abstract: Objective: To prepare aspirin floating tablets which used the oyster shell powder and sodium carboxymethyl cellulose (CMC) as compound drug carrier,end investigate its release characteristics and floating property in vitro. Methods: The drug release was detected in vitro by UV spectrometry.According to the cumulative release curve,the mathematical models for the release process of each group of aspirin floating tablets were studied.And how the dosage of the oyster shell powder and sodium carboxymethyl cellulose influenced the release process was investigated. Results: The second prescription had satisfactory floating property and ideal release process in vitro,and its process accorded with zero-order kinetics process of the medicine characteristic.The simulation equation was Q =0.080 4 t+0.146 2 with the R (correlation coefficient)=0.998 7. Conclusion:: Aspirin floating tablets were prepared and the drug release equation and release pattern was established.
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Key words:
- oyster shell powder /
- aspirin /
- floating tablets /
- release
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