硫磺凝胶的研制与临床应用
Preparation and clinical application of the gel of sulfur
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摘要: 目的 研制硫磺凝胶,观察其临床应用效果。方法 以卡波树脂-Ⅰ为基质制备硫磺凝胶,建立质量控制方法 ,经离心、恒温加速实验和常温放置考察稳定性;建立治疗组应用于 52例疥疮患者,以硫磺软膏为对照组应用于 40例疥疮患者,观察治疗效果。结果 凝胶制备工艺简单,质量稳定;治疗组 52例患者全部治愈,无一例发生任何不良反应;对照组治愈 38例,显效 2例,9例出现局部丘疹等不良反应。结论 硫磺凝胶能满足临床应用要求,不良反应少,有推广价值。Abstract: OBJECTIVE To develop the gel of sulfur and observe the clinical effect of the gel.METHODS The gel of sulfur was prepared by Carbopol-Ⅰ as the gel stroma,and the method of quality control was built up.52 cases with scabies were treated by the gel of sulfur while 40 cases were treated by the ointment of sulfur as control group.RESULTS The produce of the gel was easy and the stability was good.No side-effect was found in the gel group.CONCLUSIONS The gel is suitable to the clinical need,it is worthy to develop in clinic.
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Key words:
- the gel of sulfur /
- scabies /
- preparation /
- clinical application
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