Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 30 Issue 4
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(4): 302-304

LIU Qian-ying, YIN An-fan, NIU Zhi-ying. Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 302-304.
Citation: LIU Qian-ying, YIN An-fan, NIU Zhi-ying. Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 302-304.
shu

Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection

  • Beijing Double-crane Pharmaceutical Co., Ltd, Beijing 100102, China

  • Received Date: 2011-12-27
  • Rev Recd Date: 2012-02-27
  • Objective To investigate the effects of Fe“on the stability of ornidazole and sodium chloride injection,and ensure the safety in elinical utility. Methods Two kinds of ornidazole and sodium chloride injection which contain no Fe3+ and trace Fe3+ were prepared respectively, The content of ornidazole was determined by HPLC at different temperatures and times,which was used to study chemical dynamics of ornidazole, According to Arrhenitls equation,stability of two kinds of ornidazole and sodium ehloride injection at room temperature were forecasted. Results The degradation of ornidazole followed the first-order reaction kinetics model. At 25℃,t0.9 of ornidazole and sodium chloride injection which not containing Fe3+ and containing trace Fe3+ were 1.71 years and 1.11 years separately. Conclusions Trace Fe3+ could accderate the degradation of ornidazole.which shortened storage period of ornidazole and sodium chloride injection.
  • 加载中
通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2690) PDF downloads(939) Cited by()

Related
Proportional views

Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection

  • Beijing Double-crane Pharmaceutical Co., Ltd, Beijing 100102, China
  • Received Date: 2011-12-27
  • Rev Recd Date: 2012-02-27

Abstract: Objective To investigate the effects of Fe“on the stability of ornidazole and sodium chloride injection,and ensure the safety in elinical utility. Methods Two kinds of ornidazole and sodium chloride injection which contain no Fe3+ and trace Fe3+ were prepared respectively, The content of ornidazole was determined by HPLC at different temperatures and times,which was used to study chemical dynamics of ornidazole, According to Arrhenitls equation,stability of two kinds of ornidazole and sodium ehloride injection at room temperature were forecasted. Results The degradation of ornidazole followed the first-order reaction kinetics model. At 25℃,t0.9 of ornidazole and sodium chloride injection which not containing Fe3+ and containing trace Fe3+ were 1.71 years and 1.11 years separately. Conclusions Trace Fe3+ could accderate the degradation of ornidazole.which shortened storage period of ornidazole and sodium chloride injection.

LIU Qian-ying, YIN An-fan, NIU Zhi-ying. Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 302-304.
Citation: LIU Qian-ying, YIN An-fan, NIU Zhi-ying. Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 302-304.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: [email protected]

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return