The curative effect of exenatide combined pioglitazone on type 2 diabetes

Key words: 
• diabetes /
• type 2 /
• exenatide /
• pioglitazone /
• obesity

Abstract: Objective To observe the effect and safety of exenatide combined pioglitazone on type 2 diabetes.Methods 68 patients with type 2 diabetes who took pioglitazone for some time and still could not control the blood glucose effectively.In that case,every patient in treatment group was given exenalide for three months.The variation of the fasting blood-glucose (FPG)、blood glucose after the meal for 2 hours (2hPG)、HbAlC、cholesterol (TC)、triglyeeride (TG)、high-density lipoprotein cholesterol (HDL-C)、lowdensity lipoprotein cholesterol (LDL-C)、cpeptides (C-P) and body mass index (BMI) were observed before and after treatment.Insulin resistance (HOMA-IR) and islet β-cell function （HOMA-β) Were calculate.Results After the treatment,BMI、FPG、2hPG、HbAlC、HOMA-IR、TC and TG were decreased,but C-P、HOMA-β were improved as compared with pre-treatment (P<0.05).Conclusion Exenatide combined pioglitazonc could change thc blood glucose of the patients with type 2 diabetes,which didn't increase the risk of law blood glucose. It also could reduce the patient's weight and improve the patient's quality of life.