CAI Zhan, JIANG Zhi-hui, ZHAO Ming-zhu, ZHANG Da-zhi, ZANG Cheng-xu, HUANG Jing-hua. Optimization of synthetic process of bendamustin[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 453-454.
| Citation:
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CAI Zhan, JIANG Zhi-hui, ZHAO Ming-zhu, ZHANG Da-zhi, ZANG Cheng-xu, HUANG Jing-hua. Optimization of synthetic process of bendamustin[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 453-454.
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Optimization of synthetic process of bendamustin
- 1.
Department of Organic Chemistry, School of pharmacy, Second Military Medical University, Shanghai200433, China
- 2.
Guilin Eight plus one Pharmaceutical Co., Ltd., Gui Lin 541004, China
- Received Date: 2011-01-05
- Rev Recd Date:
2011-05-09
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Abstract
Objective To optimize the synthetic process of bendamustin for high purity. Methods Bendamustin was prepared from 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester by reduction,substitution,hydrolization and salification,successively. Results A good process for preparation of bendamustin was successfully achieved with low cost, easy operation and high purity. Conclusion The overall yield of the new process was 62%, which was more suitable for industrial production.
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