Advances in terpene trilactones of Ginkgo leaves

LIU Bin-guo; ZHANG Xin-ping; LIU Yan

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Of all the compound classes present in G. biloba, the terpene trilactones had received the most attention. The ginkgolides and bilobalide were selective platelet-activating factor antagonists and widely applied in the illness of blood vessel of heart and brain. Studies on the chemical constituents, extraction and separation, the determination of content and the pharmacological activity about terpene trilactones of Ginkgo leaves were summarized and the study prospect were made.

Advances in terpene trilactones of Ginkgo leaves

254th Hospital of PLA, Tianjin 300142, China

Received Date: 2011-05-11

Rev Recd Date: 2011-06-21

Key words:

Abstract: Of all the compound classes present in G. biloba, the terpene trilactones had received the most attention. The ginkgolides and bilobalide were selective platelet-activating factor antagonists and widely applied in the illness of blood vessel of heart and brain. Studies on the chemical constituents, extraction and separation, the determination of content and the pharmacological activity about terpene trilactones of Ginkgo leaves were summarized and the study prospect were made.

HTML

Reference (33)

[1]	Bikram S,Pushpinder Kr,Gopichand,et al.Biology and chemistry of Ginkgo biloba[J].Fitoterapia,2008,79(6):401.
[2]	张立国,倪力军.银杏叶浸膏浸取溶剂和浸取工艺的研究[J].中成药,2000,22(2):115.
[3]	王成章,郁青,谭卫红,等.溶剂萃取银杏内酯的因子研究[J].天然产物研究与开发,1998, 11(2):53.
[4]	何君,何照范,张勇民,等.DA201型大孔吸附树脂分离银杏叶提取物中银杏内酯A、B、C和白果内酯的研究[J].中草药,2004,35(12):1359.
[5]	韩亚荣.银杏内酯的提取分离及药理作用研究[J].四川医学,2009,30(6):804.
[6]	邓启焕,高勇.第二类超临界流体萃取银杏叶有效成分的实验研究[J].中草药,1999,30(6):419.
[7]	Kakigi Y, Mochizuki N, Icho T, et al.Analysis of terpene lactones in a Ginkgo leaf extract by high-performance liquid chromatography using charged aerosol detection[J].Biosci Biotechnol Biochem.,2010,74(3):590.
[8]	Gogös E.Identification and the retention index of bilobalide and ginkgolides using capillary gas chromatography[J].J Chromatogr Sci,2002,40(9):519.
[9]	刘红梅,周庆霞,杨文玲.毛细管柱气相色谱法测定银杏叶提取物中银杏萜内酯含量[J].理化检验,2008,44(10):982.
[10]	冷平生,王天华,吴京科,等.银杏萜类内酯的提取和气相色谱与质谱分[J].北京林业大学学报,2000,22(5):19.
[11]	廖咏玲,许锋,朱俊,等.大口径毛细管气相色谱分离和测定银杏叶萜内酯的方法建立[J].西北农业学报,2008,17(1):146.
[12]	Van Beek TA.Chemical analysis of Ginkgo biloba leaves and extracts[J].J Chromatogr A.,2002,967(1):21.
[13]	颜玉贞,谢培山,钱培良,等.银杏提取物及制剂薄层荧光扫描定量测定研究[J].中国中药杂志,1997,22(3):159.
[14]	唐于平,楼凤昌,郑已平.薄层扫描法测定银杏提取物萜内酯的含量[J].药物分析杂志,1998,5:305.
[15]	陆涌.薄层扫描法测定银杏叶浸膏中白果内酯含量[J].中成药,2000,22 (7):474.
[16]	Logani S,Chen MC,Tran T,et al.Actions of Ginkgo biloba related to potential utility for the treatment of conditions involving cerebral hypoxia[J].Life Sci,2000,67(12):1389.
[17]	Wu XF,Wang QJ,Lou FC.Protective effect of ginkgolides on rat focal brain ischemia[J].J China Pharm Univ,2001,32(2):141.
[18]	Marrache AM,Femand GJ,Sylvie G,et al.Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear Receptor[J].Journal of Immunology,2002,169:6474.
[19]	徐静,孙长凯,王冬梅,等.白果内酯对谷氨酸兴奋毒性致神经损害的保护作用[J].中草药,2009,40(10):1593.
[20]	彭珊瑛,廖文辉,聂珍贵,等.银杏内酯B对星形胶质细胞释放 NO、IL-6 及趋化因子 RANTES 的影响[J].药学学报,2010,45(9):1103.
[21]	Chen L,Liu CJ,Tang M,et al.Action of beta-amyloid peptide_(1-40)on I_(HVA) and its modulation by ginkgolide B[J].Acta Physiol Sin,2006,58(1):14.
[22]	Wai EH,Rao MR,Ji ND,et al.Inhibitory effects of ginkgolides B on proliferation of bovine aortic smooth muscle cells[J].Acta Pharm Sin,2002,37(2):90.
[23]	陆晓茜,李晓冬,祖淑玉,等.弱氧化修饰低密度脂蛋白诱导ECV304组织因子基因表达及银杏内酯B的抑制作用[J].基础医学与临床,2002,22(3):241.
[24]	尹艳艳,闵小芬,李维祖.银杏内酯对心肌缺血犬血流动力学的影响[J].中药材,2010,33(5):759.
[25]	郑锐,李维祖,闵小芬,等.银杏内酯滴丸对异丙肾上腺素致心肌损伤的影响[J].时珍国医国药,2010,21(5):1257.
[26]	李佳,张常娥.银杏内酯A预防大鼠应激性溃疡的实验研究[J].咸宁学院学报(医学版),2004,18(2):95.
[27]	Pilija V,Mirjana R,Brenesel MD,et al.Inhibitory effect of Ginkgo biloba extract on the tonus of the small intestine and the colon of rabbits[J].Molecules,2010,15(4):2079.
[28]	Chávez-Morales RM,Jaramillo-Juárez F.Protective effect of Ginkgo biloba extract on liver damage by a single dose of CCl₄ in male rats[J].Hum Exp Toxicol,2011,30(3):209.
[29]	高建,郜文,成亮,等.银杏内酯吸入剂对哮喘模型豚鼠气管嗜酸性粒细胞浸润的影响[J].中国药房,2007,18(15):1132.
[30]	董竟成.银杏苦内酯拮抗血小板活化因子部分体外作用的实验研究[J].中西医结合杂志,1995,15(10):606.
[31]	翁志媛,温捷,于力.银杏内酯对大鼠肾小球系膜细胞-B1及细胞外基质分泌的影响[J].广东医学,2010,31(4):427.
[32]	任国辉,李悦,叶任高,等.血小板活化因子受体拮抗剂对实验性肾病综合征的疗效观察及机制探讨[J].中国病理生理杂志,2000,16(5):466.
[33]	张世玲,娄红祥,李聪然.银杏内酯对腺嘌呤致肾功能不全的保护作用研究[J].中成药,2003,25(3):140.

Message Board

Advances in terpene trilactones of Ginkgo leaves

Abstract

References

Proportional views

通讯作者: 陈斌, [email protected]

Article Metrics

Related

Proportional views