Progress on the clinical application of traditional Chinese medicine in treatment of rheumatoid arthritis

ZHAO Ling; HU Yao-hua; LIU Run-hui; ZHANG Wei-dong; ZHENG Yi-nan; LIU Wen-cong

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Volume 29 Issue 6

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2011 > 29(6): 416-420,425

ZHAO Ling, HU Yao-hua, LIU Run-hui, ZHANG Wei-dong, ZHENG Yi-nan, LIU Wen-cong. Progress on the clinical application of traditional Chinese medicine in treatment of rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 416-420,425.

Citation:

ZHAO Ling, HU Yao-hua, LIU Run-hui, ZHANG Wei-dong, ZHENG Yi-nan, LIU Wen-cong. Progress on the clinical application of traditional Chinese medicine in treatment of rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 416-420,425.

Progress on the clinical application of traditional Chinese medicine in treatment of rheumatoid arthritis

1.
College of Traditional Chinese Medicine, Agricultural University of Jilin, Changchun 130118, China
2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2011-02-24
Rev Recd Date: 2011-03-24

Abstract

Objective Rheumatoid arthritis (RA) was a systemic autoimmune disease, and known to cause continuous pain, recurrent process, and high rate of disability. It was a kind of diseases which was difficult to cure. Currently, the drug treatment, such as, non-steroidal anti-inflammatory drugs (NSAIDs), hormone drugs, and biological agents, cost too much and produce side effects after long-term utility, which limit their application. Because of the advantages of better efficacy and less side effects, traditional Chinese medicine (TCM) had been widely used for the treatment of RA. Recent progresses in the research of TCM treatment and clinical application of RA were reviewed in this paper.
- rheumatoid arthritis,
- TCM,
- therapy,
- clinical application

References

[1]	David LS, Frederick W, Tom WJH. Rheumatoid arthritis[J]. Lancet,2010,376: 1094.
[2]	石雪蓉.中医药诊治类风湿关节炎的研究现状[J].四川解剖学杂志,2010,18(1):31.
[3]	邹伯琦.辨治类风湿性关节炎33例的体会[J].江西中医药,1995,26(2):26.
[4]	吴彪,吴建峰.治疗类风湿关节炎的药学进展[J].中国中医药咨讯,2010,2(9):231.
[5]	张涛,柳朝阳,张鹏霞,等.川芎嗪对佐剂性关节炎大鼠滑膜细胞TNF-α表达影响的实验研究[J].中国老年学杂志,2009,29(6):659.
[6]	马强,陈刚,张继芬,等.川芎嗪调控血管内皮生长因子与抗大鼠佐剂性关节炎的相关性研究[J].中国中药杂志,2009,34(21):2799.
[7]	Amett FC. The American rheumatism association 1987 revised criteria the classification of rheumatoid arthritis[J].Arthritis Rheum,1988,31(3):315.
[8]	王勇,方勇飞,周新,等.不同浓度青藤碱对大鼠滑膜细胞因子mRNA表达的影响[J].中国中医药信息杂志,2003,10(12):25.
[9]	肖涟波,欧阳桂林,张新文,等.青藤碱对类风湿关节炎患者滑膜细胞与炎性细胞黏附作用的研究[J].中国基层医药,2010,17(3):410.
[10]	王勇,钟兵,方勇飞,等.青藤碱对类风湿关节炎患者炎性细胞因子及抗环瓜氨酸肽抗体的影响[J].第三军医大学学报,2005,27(15):1573.
[11]	Yin W,Wang TS,Yin FZ,et al. Analgesic and anti-inflammatory properties of brueine and brueine N-oxide extracted from seeds of strychnos nuxvomica[J].J Ethnopharm,2003,88(2-3):205.
[12]	Luo Y,Liu M,Xia X,et al.Therapeutic effect of norisoboldine, an alkaloid isolated from radix linderae on collagen-induced arthritis in mice[J].Phytomedicine,2010,17:726.
[13]	杨志霞,李振彬,孙中成,等.雷公藤多甙对胶原性关节炎大鼠血MIF、IL-1β、TNF-α含量的影响[J].中药药理与临床,2008,24(2):59.
[14]	肖诚,何颖辉,黄芳华,等.雷公藤多苷对佐剂性关节炎大鼠自由基和炎症因子的影响[J].北京医药大学学报,2006,29(6):389.
[15]	吴曙光.抗炎免疫药理学进展[M].上海:第二军医大学出版社,1997:l62.
[16]	朱蓄,魏伟,郑咏秋.白芍总苷对胶原性关节炎大鼠滑膜细胞的作用及机制[J].药学学报,2006,41(2):166.
[17]	陈宜恒.白芍总苷胶囊治疗类风湿关节炎疗效和安全性的临床研究[J].菏泽医专学报, 2004,16(2):4.
[18]	Zheng YQ,Wei W,Zhu L,et al.Effects and mechanisms of paeoniflorin,a bioactive glucoside from paeony root on adjuvant arthritis in rats[J].Inflam Res,2007,56:182.
[19]	Liu M,Dai Y,Yao XJ,et al.Anti-rheumatoid arthritic effect of madecassoside on type II collagen induced arthritis in mice[J].Inter Immunopharm,2008,8:1561.
[20]	吴虹,宋礼华,魏伟.栀子总苷的抗炎镇痛作用研究[J].中国中医药信息杂志,2006,13 (7):31.
[21]	吴虹,陈尹,魏伟,等.栀子总苷对大鼠佐剂性关节炎治疗作用及部分机制的研究[J].中国实验方剂学杂志,2008,14(11):49.
[22]	Kupchan SM,Cout WA,Dailey RG,et al.Triptolide and triptdiolide,novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii[J]. J Am Chem Soc,1972,94:7194.
[23]	张前德,时彦标,谈文峰,等.雷公藤甲素对类风湿关节炎滑膜成纤维细胞系MH7A中VEGF、MMP 9水平变化的影响[J].南京医科大学学报,2008,28(7):902.
[24]	崔向军,王燕燕,韩莉,等.青蒿琥酯对佐剂性关节炎大鼠的治疗作用及对外周血T淋巴细胞肿瘤坏死因子α及白介素6的影响[J].时珍国医国药,2006,17(5):751.
[25]	王燕燕,崔向军,韩莉.青蒿琥酯对佐剂性关节炎大鼠踝关节滑膜的 NF-κB、be1 2 表达的影响[J].中国医院药学杂志,2005,25(11):1003.
[26]	Mirshafiev A,Saadat F,Attar M,et al. Design of a new line in treatment of experim ental rheumatoid arthritis by artestmate[J].Imm Immunotoxicol,2006,28(3):397.
[27]	Cuzzocrea S,Saadat F,Dipaola R,et al. Artemether: anew therapeutic strategy in experimental rheumatoid arthdtis[J].Imm Immunotoxicol,2005,27(4):615.
[28]	陈先国,宋兴福,崔向军,等.青蒿琥酯对佐剂性关节炎滑膜组织中凋亡因子Fas/FasL及 Bcl-2、Bax表达影响[J].时珍国医国药,2006,17(10):1926.
[29]	Dai QM,Fang JH,Zhang FS.Dual role of shikonin in early and late stages of collagen type II arthritis[J]. Mol Biol Rep,2009,36:1597.
[30]	吴湘慧,李娟,庞捷.类风湿关节炎大鼠模型的构建及昆明山海棠对大鼠佐剂性关节炎的干预研究[J].中药材,2009,32(5):758.
[31]	中国药典2005年版.一部[S].2005:490.
[32]	姚余有,王斌,李前进,等.黄芪总提物对佐剂性关节炎的抗氧化作用[J].中国临床药理学与治疗学,2000,5(3):224.
[33]	Kim KW,Shina YS,Kim KS,et al.Suppressive effects of bee venom on the immune responses in collagen-induced arthritis in rats[J].Phytomedicine,2008,15:1099.
[34]	梁兆祥,王典瑞,许国战.蚂蚁水提取物对小鼠免疫功能的影响[J].第四军医大学吉林军医学院学报,2002,22(3):130.
[35]	吴彪,吴建峰.治疗类风湿关节炎的药学进展[J].中国中医药咨讯,2010,2(9):231.
[36]	丁凡,张艳春,畅亦杰.三乌芍蝎汤对类风湿关节炎患者细胞因子IL-18,TNF-α,IL-4,IL-10水平的影响[J].中国中药杂志,2010,35(6):790.
[37]	董宏生,陈嚣,李春红,等.中药痹愈汤对类风湿关节炎骨破坏和修复的实验研究[J].中国实验方剂学杂志,2009,15(8):80.
[38]	黄艳,周学平,王明艳,等.清络通痹颗粒对类风湿关节炎患者成纤维样滑膜细胞增殖及RANKL表达的影响[J].中药新药与临床药理,2009,20(6):510.
[39]	刘亦恒,张海英,臧洪敏,等.抗风湿颗粒对胶原诱导关节炎大鼠骨保护素、核因子-κB受体激活因子配体和巨噬细胞集落刺激因子表达的影响[J].中西医结合学报,2006,4(3):307.
[40]	中国人民解放军第二军医大学.中药黄连解毒汤在制备防治类风湿关节炎的药物中的应用[P].中国专利,200910195341,2010-02-24.
[41]	李志亮.中药治疗风湿、类风湿关节炎58例[J].陕西中医,2002,23(6):51.
[42]	李景怡,吴玉章,陈永文,等.盐酸青藤碱抑制小鼠胶原性关节炎的实验研究[J].免疫学杂志,2005,21(4):313.
[43]	李宁宁.雷公藤多苷对类风湿性关节炎患者血浆TNF-α、IL-6的影响[J].广西医科大学学报,2005,22(5):681.
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[46]	张芳,张之澧,沈杰,等.乌梢蛇水解液治疗类风湿性关节炎120例临床观察[J].上海中医药大学学报,2001,15(2):22.
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[50]	单人骏,单人定.复方龙蛇散治疗类风湿性关节炎临床疗效观察[J].中华现代中医学杂志, 2010,6(4):223.

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沈阳化工大学材料科学与工程学院沈阳 110142

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Progress on the clinical application of traditional Chinese medicine in treatment of rheumatoid arthritis

1. College of Traditional Chinese Medicine, Agricultural University of Jilin, Changchun 130118, China

2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2011-02-24

Rev Recd Date: 2011-03-24

Key words:

Abstract: Objective Rheumatoid arthritis (RA) was a systemic autoimmune disease, and known to cause continuous pain, recurrent process, and high rate of disability. It was a kind of diseases which was difficult to cure. Currently, the drug treatment, such as, non-steroidal anti-inflammatory drugs (NSAIDs), hormone drugs, and biological agents, cost too much and produce side effects after long-term utility, which limit their application. Because of the advantages of better efficacy and less side effects, traditional Chinese medicine (TCM) had been widely used for the treatment of RA. Recent progresses in the research of TCM treatment and clinical application of RA were reviewed in this paper.

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Reference (50)

[1]	David LS, Frederick W, Tom WJH. Rheumatoid arthritis[J]. Lancet,2010,376: 1094.
[2]	石雪蓉.中医药诊治类风湿关节炎的研究现状[J].四川解剖学杂志,2010,18(1):31.
[3]	邹伯琦.辨治类风湿性关节炎33例的体会[J].江西中医药,1995,26(2):26.
[4]	吴彪,吴建峰.治疗类风湿关节炎的药学进展[J].中国中医药咨讯,2010,2(9):231.
[5]	张涛,柳朝阳,张鹏霞,等.川芎嗪对佐剂性关节炎大鼠滑膜细胞TNF-α表达影响的实验研究[J].中国老年学杂志,2009,29(6):659.
[6]	马强,陈刚,张继芬,等.川芎嗪调控血管内皮生长因子与抗大鼠佐剂性关节炎的相关性研究[J].中国中药杂志,2009,34(21):2799.
[7]	Amett FC. The American rheumatism association 1987 revised criteria the classification of rheumatoid arthritis[J].Arthritis Rheum,1988,31(3):315.
[8]	王勇,方勇飞,周新,等.不同浓度青藤碱对大鼠滑膜细胞因子mRNA表达的影响[J].中国中医药信息杂志,2003,10(12):25.
[9]	肖涟波,欧阳桂林,张新文,等.青藤碱对类风湿关节炎患者滑膜细胞与炎性细胞黏附作用的研究[J].中国基层医药,2010,17(3):410.
[10]	王勇,钟兵,方勇飞,等.青藤碱对类风湿关节炎患者炎性细胞因子及抗环瓜氨酸肽抗体的影响[J].第三军医大学学报,2005,27(15):1573.
[11]	Yin W,Wang TS,Yin FZ,et al. Analgesic and anti-inflammatory properties of brueine and brueine N-oxide extracted from seeds of strychnos nuxvomica[J].J Ethnopharm,2003,88(2-3):205.
[12]	Luo Y,Liu M,Xia X,et al.Therapeutic effect of norisoboldine, an alkaloid isolated from radix linderae on collagen-induced arthritis in mice[J].Phytomedicine,2010,17:726.
[13]	杨志霞,李振彬,孙中成,等.雷公藤多甙对胶原性关节炎大鼠血MIF、IL-1β、TNF-α含量的影响[J].中药药理与临床,2008,24(2):59.
[14]	肖诚,何颖辉,黄芳华,等.雷公藤多苷对佐剂性关节炎大鼠自由基和炎症因子的影响[J].北京医药大学学报,2006,29(6):389.
[15]	吴曙光.抗炎免疫药理学进展[M].上海:第二军医大学出版社,1997:l62.
[16]	朱蓄,魏伟,郑咏秋.白芍总苷对胶原性关节炎大鼠滑膜细胞的作用及机制[J].药学学报,2006,41(2):166.
[17]	陈宜恒.白芍总苷胶囊治疗类风湿关节炎疗效和安全性的临床研究[J].菏泽医专学报, 2004,16(2):4.
[18]	Zheng YQ,Wei W,Zhu L,et al.Effects and mechanisms of paeoniflorin,a bioactive glucoside from paeony root on adjuvant arthritis in rats[J].Inflam Res,2007,56:182.
[19]	Liu M,Dai Y,Yao XJ,et al.Anti-rheumatoid arthritic effect of madecassoside on type II collagen induced arthritis in mice[J].Inter Immunopharm,2008,8:1561.
[20]	吴虹,宋礼华,魏伟.栀子总苷的抗炎镇痛作用研究[J].中国中医药信息杂志,2006,13 (7):31.
[21]	吴虹,陈尹,魏伟,等.栀子总苷对大鼠佐剂性关节炎治疗作用及部分机制的研究[J].中国实验方剂学杂志,2008,14(11):49.
[22]	Kupchan SM,Cout WA,Dailey RG,et al.Triptolide and triptdiolide,novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii[J]. J Am Chem Soc,1972,94:7194.
[23]	张前德,时彦标,谈文峰,等.雷公藤甲素对类风湿关节炎滑膜成纤维细胞系MH7A中VEGF、MMP 9水平变化的影响[J].南京医科大学学报,2008,28(7):902.
[24]	崔向军,王燕燕,韩莉,等.青蒿琥酯对佐剂性关节炎大鼠的治疗作用及对外周血T淋巴细胞肿瘤坏死因子α及白介素6的影响[J].时珍国医国药,2006,17(5):751.
[25]	王燕燕,崔向军,韩莉.青蒿琥酯对佐剂性关节炎大鼠踝关节滑膜的 NF-κB、be1 2 表达的影响[J].中国医院药学杂志,2005,25(11):1003.
[26]	Mirshafiev A,Saadat F,Attar M,et al. Design of a new line in treatment of experim ental rheumatoid arthritis by artestmate[J].Imm Immunotoxicol,2006,28(3):397.
[27]	Cuzzocrea S,Saadat F,Dipaola R,et al. Artemether: anew therapeutic strategy in experimental rheumatoid arthdtis[J].Imm Immunotoxicol,2005,27(4):615.
[28]	陈先国,宋兴福,崔向军,等.青蒿琥酯对佐剂性关节炎滑膜组织中凋亡因子Fas/FasL及 Bcl-2、Bax表达影响[J].时珍国医国药,2006,17(10):1926.
[29]	Dai QM,Fang JH,Zhang FS.Dual role of shikonin in early and late stages of collagen type II arthritis[J]. Mol Biol Rep,2009,36:1597.
[30]	吴湘慧,李娟,庞捷.类风湿关节炎大鼠模型的构建及昆明山海棠对大鼠佐剂性关节炎的干预研究[J].中药材,2009,32(5):758.
[31]	中国药典2005年版.一部[S].2005:490.
[32]	姚余有,王斌,李前进,等.黄芪总提物对佐剂性关节炎的抗氧化作用[J].中国临床药理学与治疗学,2000,5(3):224.
[33]	Kim KW,Shina YS,Kim KS,et al.Suppressive effects of bee venom on the immune responses in collagen-induced arthritis in rats[J].Phytomedicine,2008,15:1099.
[34]	梁兆祥,王典瑞,许国战.蚂蚁水提取物对小鼠免疫功能的影响[J].第四军医大学吉林军医学院学报,2002,22(3):130.
[35]	吴彪,吴建峰.治疗类风湿关节炎的药学进展[J].中国中医药咨讯,2010,2(9):231.
[36]	丁凡,张艳春,畅亦杰.三乌芍蝎汤对类风湿关节炎患者细胞因子IL-18,TNF-α,IL-4,IL-10水平的影响[J].中国中药杂志,2010,35(6):790.
[37]	董宏生,陈嚣,李春红,等.中药痹愈汤对类风湿关节炎骨破坏和修复的实验研究[J].中国实验方剂学杂志,2009,15(8):80.
[38]	黄艳,周学平,王明艳,等.清络通痹颗粒对类风湿关节炎患者成纤维样滑膜细胞增殖及RANKL表达的影响[J].中药新药与临床药理,2009,20(6):510.
[39]	刘亦恒,张海英,臧洪敏,等.抗风湿颗粒对胶原诱导关节炎大鼠骨保护素、核因子-κB受体激活因子配体和巨噬细胞集落刺激因子表达的影响[J].中西医结合学报,2006,4(3):307.
[40]	中国人民解放军第二军医大学.中药黄连解毒汤在制备防治类风湿关节炎的药物中的应用[P].中国专利,200910195341,2010-02-24.
[41]	李志亮.中药治疗风湿、类风湿关节炎58例[J].陕西中医,2002,23(6):51.
[42]	李景怡,吴玉章,陈永文,等.盐酸青藤碱抑制小鼠胶原性关节炎的实验研究[J].免疫学杂志,2005,21(4):313.
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Progress on the clinical application of traditional Chinese medicine in treatment of rheumatoid arthritis

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通讯作者: 陈斌, [email protected]

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