Study on synthesis of Fmoc-L-Asp-4-OBn

WANG Liang; NI Lan; ZHANG Chun-Mei; GUO Jun-Xiang; HU Hong-Gang; WU Qiu-Ye

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Volume 29 Issue 1

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2011 > 29(1): 27-28

WANG Liang, NI Lan, ZHANG Chun-Mei, GUO Jun-Xiang, HU Hong-Gang, WU Qiu-Ye. Study on synthesis of Fmoc-L-Asp-4-OBn[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 27-28.

Citation:

WANG Liang, NI Lan, ZHANG Chun-Mei, GUO Jun-Xiang, HU Hong-Gang, WU Qiu-Ye. Study on synthesis of Fmoc-L-Asp-4-OBn[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 27-28.

Study on synthesis of Fmoc-L-Asp-4-OBn

1.
School of Pharmacy, Yantai University, Yantai, 264005; Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2.
313th Hospital of PLA, Huludao 125000, China
3.
Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2010-06-21
Rev Recd Date: 2010-07-31

Abstract

Objective To design and synthetize new derivatives of aspartic acid from L-Asp-1-OtBu and to study the importance of new derivatives in the synthesis of cyclic peptide. Methods Starting from L-Asp-1-OtBu, the benzyl was introduced on the four position of the carbon, and then the tBu protecting was removed from the one position of the carbon to synthesis of the desired target compounds. Structures of these compounds were confirmed by MS, ¹H-NMR.Results The Fmoc-L-Asp-4-OBn was synthetized with, yield of 61.3%. Conclusion The synthetic method is feasible, simple and with high yield for cyclic peptide synthesis.
- Fmoc-L-Asp-4-Obn,
- aspartic acid,
- synthesis

References

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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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