ZHANG Wei, GAO Jing, ZHANG Min, WANG Xiao-Yu, HOU Xue-Mei, GAO Shen. Bio-efficacy of seven skin-lighteners on dermal melanocytes in vitro[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 24-26,40.
| Citation:
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ZHANG Wei, GAO Jing, ZHANG Min, WANG Xiao-Yu, HOU Xue-Mei, GAO Shen. Bio-efficacy of seven skin-lighteners on dermal melanocytes in vitro[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 24-26,40.
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Bio-efficacy of seven skin-lighteners on dermal melanocytes in vitro
- 1.
Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
- 2.
Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Received Date: 2010-07-05
- Rev Recd Date:
2010-12-17
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Abstract
Objective To investigate the bio-efficacy of seven skin-lighteners on melanocytes in vitro. Methods After B-16 melanoma cells were treated with skin-lightener, the tyrosinase activity, the melanin content and cell viability were measured by utilization of L-Dopa as the substrate, colorimetric analysis, and MTT assay, respectively. Results each of the skin-lighteners showed a concentration-dependent reduction in tyrosinase activity and the melanin content and partially inhibited the cell viability. Conclusion all of the seven skin-lighteners could inhibit the melanocytes to produce melanin.
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