Study on safety pharmacology of HR0905

Key words: 
• HR0905 /
• safety pharmacology /
• cardiovascular system /
• respiratory system /
• nervous system

Abstract: Objective To study the effects of HR0905 on nervous system of mice and cardiovascular and respiratory systems of beagle dogs. Methods The mice were randomly divided into high,medium and low dose group and control group which received a single dose of 30,100,300 and 0 mg/kg of HR0905 by intragastric(ig) administration respectively and the spontaneous activities and pull-down ability of animals were observed.The beagle dogs were also randomly divided into high,medium and low dose group and control groups which received a single dose of 2,6,20 and 0 mg/kg HR0905 by ig administration respectively and the blood pressure,ECG,respiratory rate and width of dogs were measured. Results Compared with the vehicle control group,the pole climbing ability of the high dose group decreased significantly after a single ig administration of HR0905.Then a downward trend of spontaneous activity was observed in the animals 1.5 h after the administration,and the peak value was detected at 3.5 h.After a single ig administration of HR 0905,the heart rate of beagle dogs decreased significantly.The systolic blood pressure,diastolic blood pressure,mean arterial pressure,heart rate and respiratory rate of beagle dogs were decreased 2.0 h after administration in the medium and high dose groups,and the peak vale was detected at 4.0 h after administration.HR0905 had no significant effects on P-wave voltage,T wave voltage,QRS interval,PR interval,QT interval,ST segment of ECG of Beagle dogs.HR0905 had no significant effects on respiratory frequency,amplitude and rhythm in Beagle dogs. Conclusion HR0905 had certain effects on cardiovascular and nervous system.The compound could decrease the heart rate of the dogs.There was a downward trend in systolic blood pressure,diastolic blood pressure,mean arterial pressure of beagle dogs.The pole climbing ability of mice decreases significantly and spontaneous activity experiences a downward trend.