Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.
Citation: LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.

Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant

  • Received Date: 2010-03-25
  • Rev Recd Date: 2010-06-02
  • Objective To study the effect and mechanisms of timosaponin B-Ⅱ on depression. Methods The tail suspension test(TST),forced swimming test(FST),open field activity test(OFA),APO-induced synergistic action test,inhibiting reuptake of monoamine neurotransmitters and monoamine oxidase inhibitor(MAOI) test,yohimbine-induced lethality test and 5-HTP-induced head-twitch test were carried out to examine the antidepressant effect and mechanisms of timosaponin B-Ⅱ in rats.Immobility duration in FST and TST,spontaneous activity frequency in OFA,the stereotyped behaviors scores in APO-induced synergistic action test,and mortality in the other tests were observed. Results Timosaponin B-Ⅱ(100、150mg/kg) could effectively shorten the immobility time in TST and FST,but all dosages showed no significant effect on the spontaneous activity frequency in OFA.Timosaponin B-Ⅱ(150 mg/kg) significantly increased the rate of death of injecting dopamine,but had no obvious effect on the inhibiting reuptake of NE.Timosaponin B-Ⅱ(100、150 mg/kg) enhanced the apomorphine-induced stereotypy remarkably,which with statistically significant differences(P<0.05),and increased the head-twitch response evoked by 5-HTP,but had no effect on the yohimbine toxicity. Conclusion Timosaponin B-Ⅱhas significant antidepressant effect which may be related to the potentiation of brain 5-HT nerve system and DA nerve system.
  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-0401234Highcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 85.6 %FULLTEXT: 85.6 %META: 11.9 %META: 11.9 %PDF: 2.5 %PDF: 2.5 %FULLTEXTMETAPDFHighcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 28.5 %其他: 28.5 %China: 1.6 %China: 1.6 %Korea Republic of: 0.3 %Korea Republic of: 0.3 %[]: 0.3 %[]: 0.3 %上海: 2.2 %上海: 2.2 %东莞: 0.3 %东莞: 0.3 %北京: 11.9 %北京: 11.9 %北海: 0.6 %北海: 0.6 %南京: 0.3 %南京: 0.3 %台北: 0.3 %台北: 0.3 %呼和浩特: 0.3 %呼和浩特: 0.3 %天津: 0.6 %天津: 0.6 %张家口: 0.3 %张家口: 0.3 %成都: 0.3 %成都: 0.3 %新余: 0.9 %新余: 0.9 %杭州: 0.3 %杭州: 0.3 %桂林: 0.3 %桂林: 0.3 %汕头: 0.6 %汕头: 0.6 %济宁: 0.3 %济宁: 0.3 %深圳: 0.3 %深圳: 0.3 %玉林: 0.3 %玉林: 0.3 %石家庄: 0.3 %石家庄: 0.3 %芒廷维尤: 16.3 %芒廷维尤: 16.3 %苏州: 0.3 %苏州: 0.3 %西宁: 31.0 %西宁: 31.0 %长沙: 0.3 %长沙: 0.3 %雅加达: 0.6 %雅加达: 0.6 %其他ChinaKorea Republic of[]上海东莞北京北海南京台北呼和浩特天津张家口成都新余杭州桂林汕头济宁深圳玉林石家庄芒廷维尤苏州西宁长沙雅加达Highcharts.com
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(3067) PDF downloads(566) Cited by()

Related
Proportional views

Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant

Abstract: Objective To study the effect and mechanisms of timosaponin B-Ⅱ on depression. Methods The tail suspension test(TST),forced swimming test(FST),open field activity test(OFA),APO-induced synergistic action test,inhibiting reuptake of monoamine neurotransmitters and monoamine oxidase inhibitor(MAOI) test,yohimbine-induced lethality test and 5-HTP-induced head-twitch test were carried out to examine the antidepressant effect and mechanisms of timosaponin B-Ⅱ in rats.Immobility duration in FST and TST,spontaneous activity frequency in OFA,the stereotyped behaviors scores in APO-induced synergistic action test,and mortality in the other tests were observed. Results Timosaponin B-Ⅱ(100、150mg/kg) could effectively shorten the immobility time in TST and FST,but all dosages showed no significant effect on the spontaneous activity frequency in OFA.Timosaponin B-Ⅱ(150 mg/kg) significantly increased the rate of death of injecting dopamine,but had no obvious effect on the inhibiting reuptake of NE.Timosaponin B-Ⅱ(100、150 mg/kg) enhanced the apomorphine-induced stereotypy remarkably,which with statistically significant differences(P<0.05),and increased the head-twitch response evoked by 5-HTP,but had no effect on the yohimbine toxicity. Conclusion Timosaponin B-Ⅱhas significant antidepressant effect which may be related to the potentiation of brain 5-HT nerve system and DA nerve system.

LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.
Citation: LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.

Catalog

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return