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Volume 28 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(3): 215-216,240

ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue. The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 215-216,240.
Citation: ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue. The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 215-216,240.
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The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone

  • School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China

  • Received Date: 2009-11-18
  • Rev Recd Date: 2010-01-23
  • Objective To investigate synthesis of medium substituted degree hydroxypropyl-β-cyclodextrins and the complex forming capability of dexamethasone. Methods Medium substituted degree hydroxypropyl-β-cyclodextrins were prepared and tested by pharmacopoeia.Dexamethasone were included with the product and performed by the phase-solubility diagram. Results The substituted degree of hydroxypropyl-β-cyclodextrins were 7.875.Dexamethasone was formed a 11 molar ratio inclusion complex with the product and improved solubility about 33 times. Conclusion The product accord with the request of pharmacopoeia.The dissolution capability of dexamethasone was increased by hydroxypropyl-β-cyclodextrins.
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The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone

  • School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China
  • Received Date: 2009-11-18
  • Rev Recd Date: 2010-01-23

Abstract: Objective To investigate synthesis of medium substituted degree hydroxypropyl-β-cyclodextrins and the complex forming capability of dexamethasone. Methods Medium substituted degree hydroxypropyl-β-cyclodextrins were prepared and tested by pharmacopoeia.Dexamethasone were included with the product and performed by the phase-solubility diagram. Results The substituted degree of hydroxypropyl-β-cyclodextrins were 7.875.Dexamethasone was formed a 11 molar ratio inclusion complex with the product and improved solubility about 33 times. Conclusion The product accord with the request of pharmacopoeia.The dissolution capability of dexamethasone was increased by hydroxypropyl-β-cyclodextrins.

ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue. The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 215-216,240.
Citation: ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue, ZHANG Yue. The complex forming ability of medium substituted degree hydroxypropyl-β-cyclodextrins on dexamethasone[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 215-216,240.
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