Orthogonal design of formula optimization for Huanggui enema

DENG Li-qin; ZHANG Yan

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Volume 28 Issue 3

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2010 > 28(3): 203-205

DENG Li-qin, ZHANG Yan. Orthogonal design of formula optimization for Huanggui enema[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 203-205.

Citation:

DENG Li-qin, ZHANG Yan. Orthogonal design of formula optimization for Huanggui enema[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 203-205.

Orthogonal design of formula optimization for Huanggui enema

Wuxi Maternal and Child Health Hospital,Wuxi 214002,China

Received Date: 2009-11-04
Rev Recd Date: 2010-01-22

Abstract

Objective To choose the best formula for Huanggui enema. Methods The orthogonal test was used to optimize formula,and the clearance index in mice and antibacterial action in vitro were observation index.The best formula was designed according to the result of this study. Results The formula is: Rhizoma Coptids 60 g,Cortex phellodendn 180 g,Ramulus Cinnamoni 120 g,Radixet Rhizoma Rhei 48 g per 1 000 ml.The clearance index in mice is greater 20%,diameter of inhibition zone is greater 35 mm. Conclusion The optimized formula is reasonable and provided an experimental basis for clinical application.
- Huanggui enema,
- orthogonal design,
- formula optimization,
- animal experiments,
- anti-bacterial test
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通讯作者: 陈斌, [email protected]

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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