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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(3): 201-202

WEN Yan, WEN Jun, TAO Xia. Determination of residual organic solvents in orlistat by headspace gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 201-202.
Citation: WEN Yan, WEN Jun, TAO Xia. Determination of residual organic solvents in orlistat by headspace gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 201-202.
shu

Determination of residual organic solvents in orlistat by headspace gas chromatography

  • 1.

    Department of Pharmacy,Chang Zheng Hospital,Second Military Medical University,Shanghai 200003,China

  • 2.

    Department of Pharmaceutical Analysis,School of Pharmacy,Seconcl Miliary Medical University,Shanghai 200433,China

  • Received Date: 2010-04-02
  • Rev Recd Date: 2010-04-27
  • Objective To establish a method for determination of four residual organic solvents in orlistat. Methods The residual organic solvents in orlistat are hexane、heptane、methanol and acetonitril.They were quantitatively determined by headspace gas chromatography(GC) on HP-INNOWAX column with FID detector,nitrogen as the carries. Results Four residual solvents were completely separated.There was a good linearity in the experimental concentration(r=0.999 0～0.999 3).The RSD of precision was less than 10%.The average recovery rate ranged from 97.1% to 101.9%.The detection limits was between 0.009～1.833 μg/ml. Conclusion The method proves to be rapid,sensitive and accurate.It can be used for quality control for the determination of four residual organic solvents in orlistat.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of residual organic solvents in orlistat by headspace gas chromatography

  • 1. Department of Pharmacy,Chang Zheng Hospital,Second Military Medical University,Shanghai 200003,China
  • 2. Department of Pharmaceutical Analysis,School of Pharmacy,Seconcl Miliary Medical University,Shanghai 200433,China
  • Received Date: 2010-04-02
  • Rev Recd Date: 2010-04-27

Abstract: Objective To establish a method for determination of four residual organic solvents in orlistat. Methods The residual organic solvents in orlistat are hexane、heptane、methanol and acetonitril.They were quantitatively determined by headspace gas chromatography(GC) on HP-INNOWAX column with FID detector,nitrogen as the carries. Results Four residual solvents were completely separated.There was a good linearity in the experimental concentration(r=0.999 0～0.999 3).The RSD of precision was less than 10%.The average recovery rate ranged from 97.1% to 101.9%.The detection limits was between 0.009～1.833 μg/ml. Conclusion The method proves to be rapid,sensitive and accurate.It can be used for quality control for the determination of four residual organic solvents in orlistat.

WEN Yan, WEN Jun, TAO Xia. Determination of residual organic solvents in orlistat by headspace gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 201-202.
Citation: WEN Yan, WEN Jun, TAO Xia. Determination of residual organic solvents in orlistat by headspace gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 201-202.
shu

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