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Volume 28 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(2): 118-121

CUI Hai-zhen, LIU Fu-qiang, WANG Yan-ping, ZHAO Nan, LI Zi-yan. Studies of preparation and in vitro Absorption of ginkgo biloba leaf in-situ nasal gel[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 118-121.
Citation: CUI Hai-zhen, LIU Fu-qiang, WANG Yan-ping, ZHAO Nan, LI Zi-yan. Studies of preparation and in vitro Absorption of ginkgo biloba leaf in-situ nasal gel[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 118-121.
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Studies of preparation and in vitro Absorption of ginkgo biloba leaf in-situ nasal gel

  • 1.

    College of pharmacy,Yanbian University,Yanji 133000,China

  • 2.

    208th Hospital of PLA,Changchun 130062,China

  • Received Date: 2009-12-29
  • Rev Recd Date: 2010-02-10
  • Objective To preparation of ginkgo biloba leaf in-situ nasal gel and exploration of the effect of sorbefacients on nasal mucosa Absorption. Methods Carbopol 934 and HPMC were used as gel matrix to prepare pH sensitive in-situ ginkgo biloba leaf nasal gel,whose viscosity,adhesion,and in vitro nasal mucosa Absorption were studied. Results The in-situ ginkgo biloba leaf gel can be best prepared with 0.8% of Carbopol 934 and 1.5% of HPMC as gel matrix.Three sorbefacients were studied.The sequence of their permeation rate were 1% of Azone > 1% of Twain-80 > 0.5% of Borneol.The drug Absorption rate increases as the Azone concentration increases,the it’s Absorption process fits Weibull equation. Conclusion The preparation technology of in-situ ginkgo biloba leaf nasal gel is viable.And Azone is the most effective sorbefacient for nasal mucosa Absorption.
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通讯作者: 陈斌, [email protected]
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Studies of preparation and in vitro Absorption of ginkgo biloba leaf in-situ nasal gel

  • 1. College of pharmacy,Yanbian University,Yanji 133000,China
  • 2. 208th Hospital of PLA,Changchun 130062,China
  • Received Date: 2009-12-29
  • Rev Recd Date: 2010-02-10

Abstract: Objective To preparation of ginkgo biloba leaf in-situ nasal gel and exploration of the effect of sorbefacients on nasal mucosa Absorption. Methods Carbopol 934 and HPMC were used as gel matrix to prepare pH sensitive in-situ ginkgo biloba leaf nasal gel,whose viscosity,adhesion,and in vitro nasal mucosa Absorption were studied. Results The in-situ ginkgo biloba leaf gel can be best prepared with 0.8% of Carbopol 934 and 1.5% of HPMC as gel matrix.Three sorbefacients were studied.The sequence of their permeation rate were 1% of Azone > 1% of Twain-80 > 0.5% of Borneol.The drug Absorption rate increases as the Azone concentration increases,the it’s Absorption process fits Weibull equation. Conclusion The preparation technology of in-situ ginkgo biloba leaf nasal gel is viable.And Azone is the most effective sorbefacient for nasal mucosa Absorption.

CUI Hai-zhen, LIU Fu-qiang, WANG Yan-ping, ZHAO Nan, LI Zi-yan. Studies of preparation and in vitro Absorption of ginkgo biloba leaf in-situ nasal gel[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 118-121.
Citation: CUI Hai-zhen, LIU Fu-qiang, WANG Yan-ping, ZHAO Nan, LI Zi-yan. Studies of preparation and in vitro Absorption of ginkgo biloba leaf in-situ nasal gel[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 118-121.
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